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A precise U-Pb baddeleyite age of 2733 +/- 2 Ma has been obtained for the Ahmeyim Great Dyke of Mauritania that intruded into the Tasiast-Tijirit Terrane of the Reguibat Shield, NW Mauritania. This dyke is approximately 1500 m wide at the sampling area and extends for more than 150 km NNE/SSW. Major and trace element geochemistry of the dyke indicates that the magmas that formed this intrusive bod
The photochemical oxidation of oceanic dissolved organic carbon (DOC) to carbon monoxide (CO) and carbon dioxide (CO2) has been estimated to be a significant process with global photoproduction transforming petagrams of DOC to inorganic carbon annually. To further quantify the importance of these two photoproducts in coastal DOC cycling, 38 paired apparent quantum yield (AQY) spectra for CO and CO
The neural correspondence between the systems responsible for the execution and recognition of actions has been suggested both in humans and non-human primates. Apart from being a key region of this visuo-motor observation-execution matching (OEM) system, the human inferior frontal gyrus (IFG) is also important for speech production. The functional overlap of visuo-motor OEM and speech, together w
Most existing remote sensing-based evapotranspiration (ET) algorithms rely exclusively on polar-orbiting satellites with thermal infrared sensors, and therefore the resulting ET values represent only "instantaneous or snapshot" values. However, daily ET is more meaningful and useful in applications. In this study, daily ET estimates are obtained by combining data from the MODIS sensor aboard the p
Combining pheromone trapping and genetic analyses can be useful whentrying to resolve complexes of closely related insect taxa that are difficult to distinguishbased on morphological characters. Nearctic and Palearctic populations of the spruceseed moth, Cydia strobilella L., have been considered taxonomically synonymoussince 1983, but more recent work revealing distinct sex pheromones for Canadia
Background:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus.Methods:To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the diagnosis of MCC using the national cancer registries in Denmark, Norway and Sweden.Results:The overall
Prior work demonstrated increased levels of hypoxia-inducible factor-1α (HIF-1α) in the bladder following outlet obstruction, associated with bladder growth and fibrosis. Here we hypothesized that HIF induction in outlet obstruction also switches energetic support of contraction from mitochondrial respiration to glycolysis. To address this hypothesis, we created infravesical outlet obstruction in
The massive amount of genomic sequence data that is now available for analyzing evolutionary relationships among 31 placental mammals reduces the stochastic error in phylogenetic analyses to virtually zero. One would expect that this would make it possible to finally resolve controversial branches in the placental mammalian tree. We analyzed a 2,863,797 nucleotide-long alignment (3,364 genes) from
Objective: Schizophrenia is associated with premature mortality, but the specific causes and pathways are unclear. The authors used outpatient and inpatient data for a national population to examine the association between schizophrenia and mortality and comorbidities. Method: This was a national cohort study of 6,097,834 Swedish adults, including 8,277 with schizophrenia, followed for 7 years (20
Functional imaging studies have revealed that certain brainstem areas are activated during migraine attacks. The neuropeptide calcitonin gene-related peptide (CGRP) is associated with activation of the trigeminovascular system, transmission of nociceptive information and plays a key role in migraine pathophysiology. Therefore, to elucidate the role of CGRP it is critical to identify the regions wi
The issue of whether major and rapid global sea-level changes existed on a preglacial Earth can be resolved by the detailed study of the Paleocene-Eocene (P-E) interval, where a large and rapid carbon isotope excursion linked to an important global warming event, the Paleocene Eocene Thermal Maximum, allows for high-resolution correlation between terrestrial, coastal and marine settings. Based pri
Vascular smooth muscle cells (SMCs) display remarkable phenotypic plasticity in response to environmental cues. The nuclear factor of activated T-cells (NFAT) family of transcription factors plays a critical role in vascular pathology. However, known functional NFAT gene targets in vascular SMCs are currently limited. Publicly available whole-genome expression array data sets were analyzed to iden
Islands allure imagination, thought and affect. Imagination, thought and affect conjure islands. Literary imaginations create islands more than any other geographical form. Metaphorically, we use concepts of bounded and contained islands to think with, to an extent not commonly recognized. Emotions and desires are moved by and commonly move us towards or away from islands. Relatedly, in a deeper t
The disease mechanisms underlying type 2 diabetes (T2D) remain poorly defined. Here we aimed to explore the pathophysiology of T2D by analyzing gene co-expression networks in human islets. Using partial correlation networks we identified a group of co-expressed genes ('module') including F2RL2 that was associated with glycated hemoglobin. F2Rl2 is a G-protein-coupled receptor (GPCR) that encodes p
Background We investigated whether prediagnostic reported intake of dairy products and dietary calcium are associated with colorectal cancer (CRC) survival. Methods Data from 3,859 subjects with CRC (42.1% male, mean age at diagnosis 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition (EPIC) cohort were analyzed. Intake of dairy products and dietary calcium was assessed at ba
