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For more than a century the research on the Antikythera Mechanism engaged scientists from a widerange of scientific disciplines searching for clues, in order to solve the mystery that this unique ar-chaeological find poses. The results so far have been spectacular enough to re-write the History ofTechnology providing new aspects on the degree of technological sophistication and scientific de-velop
The maintenance of protein homeostasis, also referred to as proteostasis, is essential for preserving the structural and functional stability of the proteome in living organisms. This involves the precise control of protein synthesis, folding, and degradation. As proteostasis disruption can cause growth and survival deficiencies in bacteria, the investigation of proteostasis has rapidly emerged as
Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. The thesis evaluates the effect of radiolabelling chemistry on biodistribution and targeting properties of Affibod
BACKGROUND: – Proteins linked to heritable coronary heart disease (CHD) could uncover new pathophysiological mechanisms of atherosclerosis. We report on the protein profile associated with a family history of early-onset CHD and whether the relation between proteins and coronary atherosclerotic burden differs according to family history status, as well as inferences from Mendelian randomization. M
Background Trauma is the leading cause of quality-related mortality in low- and middle-income countries, with an estimated two million preventable deaths each year. Although trauma quality improvement programmes have been utilised in high-income countries for more than three decades, there is no high-level evidence of their effect on patient outcomes. We aimed to assess whether implementing a cont
The early Middle Ages saw the formation of the three Nordic kingdoms of Sweden, Norway and Denmark, and at that time the area studied here constituted a border region between them. During the same period the Church was very active in the area: a bishopric was established and a large number of churches were built. This makes the area a particularly interesting one to study from the point of view of
Popular Abstract in Swedish Moraxella catarrhalis är en bakterie som man länge trodde var en del av vår normala bakterieflora och därmed ofarlig. Under de senaste tjugo åren har M. catarrhalis dock visat sig vara en av orsakerna till öroninflammation hos barn och lägre luftvägsinfektioner hos vuxna med någon annan underliggande sjukdom som t.ex. kronisk obstruktiv lungsjukdom (KOL). De senaste 10 Moraxella catarrhalis is frequently colonizing the human respiratory tract, particularly in children. This gram-negative bacterium has during the last two decades been recognized as a pathogen causing otitis media in children and lower respiratory tract infections in adults with predisposing conditions such as chronic obstructive pulmonary disease (COPD). The virulence determinants of M. catarrhal
Interleukin 6 (IL-6) is a multifunctional cytokine and a potent stimulator of bone resorption and has been implicated in the pathogenesis of osteoporosis in postmenopausal women. The aim of this study was to investigate if a functional JL-6 promoter polymorphism (-174) was related to bone mass and fractures in a cohort consisting of 964 postmenopausal Caucasian women aged 75 years. Bone mineral de
Popular Abstract in Swedish Avhandlingen handlar om hur radiovågor tar sig fram i miljöer där saker som hus, väggar och fönster är i vägen. Framför allt ligger fokus på hur signalen från en sändare placerad utomhus kan nå fram till en mobil terminal (t. ex. en mobiltelefon) som befinner sig inomhus. Hur mycket signalen dämpas när den passerar väggen är av stor betydelse när man ska avgöra hur långThis thesis deals with radio wave propagation in environments where the propagation is severely influenced by surrounding objects, mainly walls and other building structures. As an introduction, a brief description is given on propagation terms like loss, delay and dispersion along with system functions relevant for the topic. The focus is then placed on propagation from an outdoor transmitter to
PURPOSE. To study the possible involvement of the rod (SLC24A1) and cone (SLC24A2) Na-Ca+K exchanger (NCKX) genes in retinal diseases. METHODS. DNA was collected from unrelated patients with retinal disease, mainly from North America. A human genomic library was screened with the cone NCKX cDNA, and hybridizing clones were sequenced to determine the genomic organization of the SLC24A2 gene. The si
Background: Insulin is a therapeutic protein that is widely used for the treatment of diabetes. Its biological function was discovered more than 80 years ago and it has since then been characterized extensively. Crystallization of the insulin molecule has always been a key activity since the protein is often administered by subcutaneous injections of crystalline insulin formulations. Over the year
The relative complexity of the mechanisms underlying savanna ecosystem dynamics, in comparison to other biomes such as temperate and tropical forests, challenges the representation of such dynamics in ecosystem and Earth system models. A realistic representation of processes governing carbon allocation and phenology for the two defining elements of savanna vegetation (namely trees and grasses) may
Deoxyribonucleoside kinases (dNKs) carry out the rate-determining step in the nucleoside salvage pathway within all domains of life where the pathway is present, and, hence, are an indication on whether or not a species/genus retains the ability to salvage deoxyribonucleosides. Here, a phylogenetic tree is constructed for the thymidine kinase 2-like dNK gene family in metazoa. Each enzyme class (d
Plant ecologists have placed increasing emphasis on a functional understanding of vegetation. One way to gain insight into the assemblage of vegetation communities is to investigate plant trait responses to environmental gradients or experimental treatments. We present simulations of responses of suites of traits to treatments differing in soil resources and disturbance intensity, in order to cons
The paper is based on an inventory of crofts and cottages that was made in the parish of Länghem in the southern part of the province of Västergötland, Sweden at the end of the 1950ies and the beginning of the 1960ies. The parish of Länghem has both manors (the medieval Torpa and Hofsnäs and the 17th century Sällerås) and independent villages. The inventory was made quite traditionally. We tried t
Popular Abstract in Swedish Alla friska människor har 46 kromosomer, 23 av dessa härstammar från modern och 23 från fadern. Kromosomer är långa kedjor av nukleinsyror som innehåller den genetiska informationen (arvsanlagen) som behövs för att ett befruktat ägg skall kunna utvecklas till en individ bestående av miljontals celler med mycket specialiserade och avancerade uppgifter. Den här utvecklingThe cells in B cell development can be divided into several subgroups or fractions, e.g. early-pro-B-, pro-B, large-pre-B-, small-pre-B-, immature and mature B cells, where the stages reflect the maturity degree of the cells. This characterization is based on the expression of intracellular markers such as the recombination activating genes 1 and 2(Rag 1 and Rag 2), the terminal deoxynucleotidyl t
