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Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted
The ability of intrahippocampal grafts of fetal septal-diagonal band tissue, rich in developing cholinergic neurons, to ameliorate cognitive impairments induced by bilateral fimbria-fornix transections in rats was examined in three experiments using the Morris water-maze to test different aspects of spatial memory. Experiment 1. Rats with fimbriafornix lesions received either septal cell suspensio
Background: Family risks for urinary tract cancers (excluding kidney cancers) are known, but less is known about whether rare urinary tract cancer subtypes are also familial and if urinary tract cancers share familial risk for other (discordant) cancers. Objective: To investigate the impact of family history on urinary tract cancers (International Classification of Diseases version 7 code 181) and
Introduction: High-inflammation subgroups of patients with psychosis demonstrate cognitive deficits and neuroanatomical alterations. Systemic inflammation assessed using IL-6 and C-reactive protein may alter functional connectivity within and between resting-state networks, but the cognitive and clinical implications of these alterations remain unknown. We aim to determine the relationships of ele
Background: In animal models, early initiation of therapeutic cooling, intra-arrest, or restored circulation has been shown to be neuroprotective shortly after cardiac arrest. We aimed to assess the feasibility and cooling efficacy of transnasal evaporative cooling, initiated as early as possible after hospital arrival in patients randomized to cooling in the TTM2 trial. Methods: This study took t
Traumatic brain injury (TBI) is one of the leading causes of death in children worldwide. Emerging evidence suggests that alterations in mitochondrial function are critical components of secondary injury cascade initiated by TBI that propogates neurodegeneration and limits neuroregeneration. Unfortunately, there is very little known about the cerebral mitochondrial bioenergetic response from the i
Precise geochronology, combined with paleomagnetism on mafic intrusions, provides first-order information for paleoreconstruction of crustal blocks, revealing the history of supercontinental formation and break-up. These techniques are used here to further constrain the apparent polar wander path of the Kaapvaal Craton across the Neoarchean-Paleoproterozoic boundary. U-Pb baddeleyite ages of 2441
General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected risk factor for gastric cardia adenocarcinoma (GCC) and appears unrelated to gastric non-cardia adenocarcinoma (GNCC). How abdominal obesity, as commonly measured by waist circumference (WC), relates to these cancers remains largely unexplored. Using measured anthropometric data fro
Thermal-optical analysis is a conventional method for determining the carbonaceous aerosol fraction and for classifying it into organic carbon, OC, and elemental carbon, EC. Unfortunately, the different thermal evolution protocols in use can result in a wide elemental carbon-to-total carbon variation by up to a factor of five. In Europe, there is currently no standard procedure for determining the
Climate warming is more pronounced in the Arctic than in other parts of the world. This warming affects the terrestrial cryosphere including permafrost with consequences ranging from societal impacts to changes in hydrology and feedbacks in the climate system such as those imposed by changing greenhouse gas exchanges. Permafrost dynamics in a marginal zone for its very existence is in this context
The F344 rat carries alleles contributing to bone fragility while the GK rat spontaneously develops type-2 diabetes. These characteristics make F344xGK crosses well suited for the identification of genes related to bone size and allow for future investigation on the association with type-2 diabetes. The aim of this study was to identify quantitative trait loci (QTLs) for bone size phenotypes measu
The aim of this project has been to study timber house manufacturers and provide guidance to those who aim to increase efficiency through the adaption of product modeling and eventually configuration. The findings in this report are based on a series of case studies within the abovementioned industry, which serves as a basis for the analysis and recommendations given. The Swedish timber house man
Introduction: Elevated pulmonary vascular resistance (PVR) is observed in both physiological and pathological states. Pulmonary hypertension (PH) is a condition associated with significant morbidity and mortality in neonates and children and curative pharmacotherapy is lacking in most cases. In utero, a high PVR allows for blood to bypass the lungs through the open ductus arteriosus (DA). Vascular
Groundwater is the general source of drinking water in the Shimabara Peninsula, Nagasaki, Japan, and consequently, occurring nitrate nitrogen (NO3-N) pollution in the groundwater is a significant problem. Although various countermeasures have been implemented, nitrate nitrogen concentrations remain serious. Therefore, it is necessary to evaluate effects of different potentially effective counterme
Popular Abstract in Swedish En studie av hur glokokortikoider hämmar inflammation Glukokortikosteroider, varav kortison är den mest kända, är hormoner som reglerar många funktioner i kroppen och även används som läkemedel för att dämpa inflammatoriska tillstånd som t.ex. astma och reumatiska sjukdomar. Glukokortikosteroider är mycket potenta läkemedel och används flitigt med mycket goda effekter.The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. In macrophages, the synthetic glucocorticoid dexamethasone (dex) was found to reduce the expression of cPLA2 a
The enzyme ferrochelatase (EC 4.99.1.1) is the terminal enzyme in the biosynthetic pathway of heme b and catalyzes the insertion of Fe(II) into protoporphyrin IX. In this dissertation ferrochelatase from Bacillus subtilis was studied. A new purification method via inclusion bodies was developed that enabled simple purification of recombinant enzyme without tags or modifications that might affect t
Clothing evaporative resistance is one of the most important parameters for clothing comfort. The clothing evaporation resistance can be measured on a sweating guarded hotplate, a sweating thermal manikin or a human subject. The sweating thermal manikin gives the most accurate value on evaporative resistance of the whole garment ensemble compared to the other two methods. The determination of clot
Popular Abstract in Swedish Nästa år är det 400 år sedan Galileo Galilei för första gången riktade ett teleskop mot objekt på himlen. Allt sedan dess har teleskopet varit det viktigaste instrumentet för astronomins utveckling och med dess hjälp har vår kunskap om universum revolutionerats. Tack vare utvecklingen av teleskopet under dessa århundraden har allt ljussvagare objekt kunnat studeras, ochThis thesis presents the work on the design of, construction of, and finally observations with, an experimental setup comprising a small telescope equipped with adaptive optics. The facility has been assembled at Lund Observatory, where also observations on the sky have been made. The aim of this project was to gain hands-on knowledge in the development of a real adaptive optics system and eventua
