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BackgroundA novel non-invasive method for generation of pressure volume loops (PV-loops) using brachial blood pressure and cardiovascular magnetic resonance (CMR) imaging has recently been presented and validated (1). The non-invasive nature of this method enables calculation of PV-loops in large patient cohorts previously not feasible due to the need of invasive measurements.PurposeThe purpose of

Cancer of unknown primary (CUP) is diagnosed at a metastatic stage, conferring an unfavorable prognosis. The natural history of the disease is poorly understood, which complicates diagnosis, treatment and follow-up. Population-based survival data are lacking regarding location and histology of metastases. From the Swedish Cancer Registry, 18 911 CUP patients were identified between years 1987 and

A series of QM/MM optimizations of the full protein of [Fe] hydrogenase were performed. The FeGP cofactor has been optimized in the water-bound resting state (1), with a side-on bound dihydrogen (2), or as a hydride intermediate (3). For inclusion of H4MPT in the closed structure, advanced multiscale modeling appears to be necessary, especially to obtain reliable distances between CH-H4MPT+ and th

Activated coagulation factor V functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin. Based on introduction of extra carbohydrate side chains in recombinant factor V, we recently proposed several regions in factor Va to be important for factor Xa binding. To further define which residues are important for factor Xa binding, we prepared fifteen recombinant factor V varia

The role of K396 in the enzymatic catalysis and the antigenicity of the 65 kDa isoform of glutamate decarboxylase (GAD65) was analyzed using the K396R GAD65 mutant. GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease. We found that (1) recombinant human GAD65 is fully enzymatically active; (2) the K396R mutation abolished GA

Svenska Kärnbränslehanteringen (SKB) startade ett projekt under 2020 i närheten av Forsmark i Sverige med målet att utöka deformationszonsmodellen till att inkludera hela dräneringsområdet runt om det planerade slutförvaret för använt kärnbränsle. Detta arbete bygger på en lineamentmodell som var skapad för SKB. Denna modell använder sig av magnetiska data tillsammans med höjddata samt data insamlThe Swedish Nuclear Fuel and Waste Management Co. (SKB) started a project in 2020 near Forsmark, Sweden with the aim to expand the deformation zone model to encompass the entire catchment area around the planned repository for spent nuclear fuel. This thesis builds upon a lineament model that was constructed for SKB which utilizes airborne magnetic data supported by airborne Very Low Frequency (VL

The Pd-II atom in the title compound, [Pd(C2F3O2)(C24H43P2)], adopts a distorted square-planar geometry with the P atoms in a trans arrangement, forming two five-membered chelate rings. Four intramolecular C-H center dot center dot center dot O hydrogen bonds occur. The crystal packing reveals one weak intermolecular C-H center dot center dot center dot O hydrogen bond, which self-assembles the mo

The title compound, [PdBr(C24H49P2)], has a distorted square-planar coordination geometry with the P, C, P'-tridentate ligand forming two five-membered chelate rings. The Br atom is displaced from the square plane by 0.560 (6) angstrom.

The title compound, [PtCl(C32H27P2)], has a pseudo-square-planar coordination geometry around the Pt atom with the P,C,P'-tridentate ligand forming two five-membered rings that are tilted with respect to the coordination plane. The two Pt-P the Pt-Cl and the Pt-C distances are 2.2794 (9)/2.2749 (10), 2.3831 (10) and 2.002 (3) Angstrom, respectively.

Music in different forms is significant in young people’s lives. Due to the media revolution in our modern society, children of today learn a lot about music on their own by taking part in an increasing production of musical cultures. In this paper different forms of play is applied as a way to reach a deeper understanding of children’s creative music making. This article describes a 2-year empiri