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C4b-binding protein: Identification of binding sites and a possible function of the interaction with protein S

Popular Abstract in Swedish Komplementsystemet är ett system bestående av cirka 35 proteiner i blodet och på cellytor, som ingår i kroppens medfödda immunförsvar. Det är ett mycket viktigt men också explosivt system, potentiellt skadligt för kroppens egna celler, som kräver strikt reglering. Denna avhandlings huvudaktör, C4b-bindande protein (C4BP), nedreglerar komplementsystemet. C4BP har en ovanThe subject of this thesis is plasma protein C4b-binding protein (C4BP). C4BP is an important regulator of the classical pathway of the complement system, a cascade-like system comprised of over 35 proteins, which partakes in the defence against micro-organisms and is involved of clearance of immune-complexes and apoptotic cells. C4BP contains two different types of subunits, seven identical alfa-

The seashore – beyond monumentality : The case of Pitted Ware coastal sites in southern Sweden

What is the significance of a place at the seashore? What kind of a sense of place does a place by the seashore constitute in the absence of any kind of monumental structures? Today, it is obvious within the archaeological domain that archaeological material culture is not only functional, but also acts as a metaphor for people’s self-perception. In this article, my assumption is that the differen

The dorsal vagal complex as a site for cocaine- and amphetamine-regulated transcript peptide to suppress gastric emptying.

Cocaine- and amphetamine-regulated transcript-derived peptides (CARTp) and corticotropin-releasing factor (CRF) alter feeding and gastrointestinal function after central administration, and the gastric inhibitory effects are mediated through CRF. We hypothesized that dorsal hindbrain effects of CARTp on gastric emptying are mediated by the vagus nerve and that the dorsal vagal complex (DVC) is a s

Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing

The identification of unknown genomic flanking DNA sequences can be used for the molecular monitoring of retro-, lenti- and foamyviral integration, transgenes in early embryogenesis, insertional mutagenesis, cell fate, and stem cell plasticity. Most existing methods reflect shortcomings in sensitivity and or specificity, thus limiting genomic sequencing of unknown flanking DNA to clonal preparatio

The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit.

The adapter protein APS has previously been shown to be involved in recruiting the ubiquitin E3 ligase c-Cbl to the insulin receptor, the platelet-derived growth factor b-receptor and the erythropoietin receptor, leading to increased degradation of the receptors and inhibition of mitogenesis. Here we demonstrate, by use of immobilized synthetic phosphopeptides corresponding to various autophosphor

Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents

Background - Although effective coverage of challenging coronary lesions has warranted the use of overlapping drug-eluting stents, the histopathological response to stent overlap is unknown. Methods and Results - The arterial reaction to overlapping Cypher or Taxus drug-eluting stents was examined in rabbits with bare metal stents, BxVelocity or Express, serving as controls. Single iliac artery ba