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Right before northern hemisphere’s summer shifts to autumn small insect-eatingbirds start lengthy journeys to tropical regions. It is well established that temporarylack food and annual changes in weather are the ultimate reasons for this behavior.On a proximal level however, the process is poorly understood. Yet crosscontinental bird migration is a widespread phenomenon that has evolved severalti

4-1BB (CD137) is an activation-induced costimulatory receptor that regulates immune responses of activated CD8 T and natural killer cells, by enhancing proliferation, survival, cytolytic activity, and IFNγ production. The ability to induce potent antitumor activity by stimulating 4-1BB on tumor-specific cytotoxic T cells makes 4-1BB an attractive target for designing novel immuno-oncology therapeu

The accurate estimation of soil carbon (C) pool and fluxes is a prerequisite to better understand the terrestrial C feedback to climate change. However, recent studies showed considerable uncertainties in soil C estimates. To provide a reliable C estimate in the grasslands of the Qinghai-Tibet Plateau (QTP), we calibrated key parameters in a process-based ecosystem model (the CENTURY model) throug

This PhD thesis examines how application of 3D visualization and related digital analytical tools is having a transformative impact on archaeological practice via improvement of visual-spatial thinking and the strengthening of conceptual understanding. However, the deployment of these new digital methods is essentially still at an experimental stage. Therefore, the thesis undertakes a critical eva

Soil erosion has created landscape problems in many parts of the world and in particular in cold regions where the sensitive permafrost conditions have changed due to climate warming. Such a case occurred in the Tibetan Plateau (TP), which has been strongly affected by global warming and human activities. Monitoring technologies, like remote sensing and field surveys were used to explore soil eros

Late Quaternary glaciations, deglaciations, sea-level changes and aeolian activity have resulted in an abundance of clastic sediments that currently cover the three Baltic States, Northern Europe almost entirely. The chronology for these deposits has largely been established from luminescence dating. This review synthesises 201 luminescence ages obtained between 2011 and 2021 on sediments in the B

Wild insect pollinators are essential to cultivated and natural ecosystems globally. Today, many pollinator species are declining. One reason is a general lack of flowering habitats at landscape scales. However, urban areas, including private gardens, may provide flowers, and constitute beneficial habitats for pollinators. Here, we evaluate the ecological outcomes of a citizen science campaign run

Albert-László Barabási, from the introduction to his book titled Linked: the new science of networks, “Just as diverse humans share skeletons that are almost indistinguishable, we have learned that these diverse maps follow a common blueprint. A string of recent breathtaking discoveries has forced us to acknowledge that amazingly simple and far-reaching natural laws govern the structure and evolut

X-ray crystallography is the main source of atomistic information on the structure of proteins. Normal crystal structures are obtained as a compromise between the X-ray scattering data and a set of empirical restraints that ensure chemically reasonable bond lengths and angles. However, such restraints are not always available or accurate for nonstandard parts of the structure, for example substrat

Background: The signal transducer and activator of transcription 3 (STAT3) pathway is observed to be constitutively activated in several malignancies including prostate cancer (PCa). In the present study, we investigated the expression of total STAT3 (tSTAT3) and two forms of activated phosphorylated STAT3 (pSTAT3 727 and pSTAT3 705 ) in tissue microarrays (TMA) of two cohorts of localized horm

The parasitoid wasp Nasonia vitripennis is an emerging genetic model for functional analysis of DNA methylation. Here, we characterize genome-wide methylation at a base-pair resolution, and compare these results to gene expression across five developmental stages and to methylation patterns reported in other insects. An accurate assessment of DNA methylation across the genome is accomplished using

With timely allocated movement phases, mobile organisms can match their space-use with the seasonality of the environment and thereby optimise their resource utilisation over time. Long-distance avian migrants are known to move with the seasonal dynamics on an annual basis, but how individuals respond to seasonality within their tropical non-breeding range has been less studied. Here we analyse th

The risk among asphalt workers of developing adverse health effects may increase due to their occupational exposure. One area of special concern arises when rubber granules are mixed into bitumen to enhance asphalt properties. This research characterizes and compares bitumen and rubber bitumen regarding the emissions of and workers' exposure to particulates, polycyclic aromatic hydrocarbons (PAHs)

Purpose: The impact of androgen receptor (AR) activity Results: D-Norgestrel and DHT activated the AR pathway, in breast cancer biology is unclear. We characterized and while 17b-Estradiol did not. Competitive binding for AR tested a novel therapy to an AR-governed target in breast protein showed similar affinity between DHT and D-Norges-cancer. trel, indicating direct AR–ligand interaction. In vi

Historical wage studies have never been able to truly or accurately address the changes in the working year. Real wages have almost always been based on the wages of unskilled and casual laborers, typically paid by the day. Their annual incomes are not clear or obvious – the income is directly dependent on how many days they work. Implicitly the literature has assumed that the number of days worke