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Active site-inactivated factor VIIa inhibits nuclear factor kappa B activation in intestinal ischemia and reperfusion.

BACKGROUND: Intestinal ischemia and reperfusion (I/R) injury is a pivotal mechanism in critical illness and in the development of multiple organ dysfunction syndrome, in which the nuclear factor kappa B (NF-κB) activation plays a central role. Intestinal I/R injury initiates the extrinsic tissue factor or factor VIIa-dependent pathway of coagulation, also of importance in multiple organ dysfuncti

Identification of Covalent Binding Sites of Phthalic Anhydride in Human Hemoglobin.

Phthalic anhydride (PA) is a reactive low molecular weight compound used in the chemical industry. The exposure of PA may lead to work-related airway diseases such as rhinitis, chronic bronchitis, and asthma. The exposure gives rise to an increase in hapten-specific IgG antibodies in workers but with a low presence of specific IgE antibodies. In this study, the binding of PA to human hemoglobin (H

Carbon and nitrogen stable isotope values in freshwater, brackish and marine fish bone collagen from Mesolithic and Neolithic sites in central and northern Europe

The aim of this research is to examine the isotopic characterisation of archaeological fish species as it relates to freshwater, brackish and marine environments, trophic level and migration patterns, and to determine intraspecies variation within and between fish populations in different locations within central and northern Europe. Carbon and nitrogen stable isotope analysis was undertaken on co

Negative-pressure wound therapy for prevention and treatment of surgical-site infections after vascular surgery

Background: Indications for negative-pressure wound therapy (NPWT) in vascular surgical patients are expanding. The aim of this review was to outline the evidence for NPWT on open and closed wounds. Methods: A PubMed, EMBASE and Cochrane Library search from 2007 to June 2016 was performed combining the medical subject headings terms 'wound infection', 'abdominal aortic aneurysm (AAA)', 'fasciotomy

Self-assembly of oppositely charged microgels into well-defined colloidal molecule-like clusters with thermoresponsive interaction sites

In this report the preparation of colloidal molecules through electrostatically driven self-assembly of spherical, thermoresponsive microgel building blocks is investigated. Colloidal molecules are of interest to the scientific community because, unlike spherical colloids, they account for anisotropic interactions that can also be found in atomic molecules. The added benet of using thermoresponsiv

Refugia and post-glacial migration of Nigritella miniata (Orchidaceae): evidence from restriction site-associated DNA sequencing, microsatellite markers, and ecological niche modelling

Nigritella miniata is an alpine orchid species disjunctly endemic to the Eastern Alps and the Southeastern Carpathians. It is thought to have arisen only once through a hybridisation event between now extinct ancestors. Questions of interest are whether N. miniata survived in few or many isolated refugia in the Eastern Alps during the Last Glacial Maximum (LGM), and their relationship with the pop

Facility Siting with Chinese Characteristics? An Inquiry into the Relationship between International Investors and Local Environmental NGOs

As China modernizes, its waste management capacities are put to a test. Faced by significant pressures to find a solution for growing municipal solid waste, China’s authorities have embraced waste incineration technology as a seemingly cost-efficient alternative to landfills. Against this push, significant societal opposition against the construction of waste incinerators has been mounting. Yet wh

Water harvesting in Erbil Governorate, Kurdistan region, Iraq : detection of suitable sites using geographic information system and remote sensing

Popular science: Find a suitable area for rainwater harvesting Rainwater harvesting is a technique to capture and store rainfall where it falls. The technique of water harvesting can be used for different purposes, e.g providing irrigation water, drinking water, increase groundwater recharge, and reduce flood risk. The application of rainwater harvesting is suitable in arid and semi-arid areas, w

Spatial heterogeneity of soil CO2 efflux at ADVEX site Norunda in Sweden

Denna studie undersöker den rumsliga variationen i markens koldioxid-utflöde (CO2) i en boreal blandskog, huvudsakligen dominerad av tall (Pinus sylvestris L.) och gran (Picea abies L.) i ADVEX experimentsite i Norunda, centrala Sverige. Mätningar av markens CO2 gjordes i 72 collars omkring huvudtornet med hjälp av en LI-6250 infraröd gasanalysapparat kopplad till en hemmagjord mörkkammare. Medelv

Inferring the migratory status of woodland birds usisng ringing data: the case of a constant-effort site located in the Iberian highlands.

Understanding the spatiotemporal distribution of birds is crucial for effective management and conservation of their populations. However, we still have only limited knowledge not only of the wintering destinations of many Iberian breeding migrants but also of aspects as general as the migratory behaviour of the populations of many common avian species that breed in the Iberian highlands. We used

Review of methods used for lowering groundwater levels at archeological sites, Egypt

Seven or eight thousand years ago, as the farthest the human memory can reach, the Egyptians established a great civilization that was considered as the origin of civilization on the Earth. There is no place in Egypt where man cannot find evidence that enlighten this civilization and tell about Egypt's role in most of the world's historic events from the beginning of mankind until the pres

Monitoring of a multi-span prestressed concrete bridge using satellite interferometric data and comparison with on-site sensor results

Satellite-based Synthetic Aperture Radar Interferometry (InSAR) represents a promising supplement to traditional Structural Health Monitoring (SHM) methods, offering a non-invasive solution that eliminates the need for sensor installations and provides extensive spatial coverage. The European Ground Motion Service (EGMS), developed by the European Space Agency under the Copernicus program, marks a

Assimilating multi-site eddy-covariance data to calibrate the wetland CH4 emission module in a terrestrial ecosystem model

In this study, we use a data assimilation framework based on the adaptive Markov chain Monte Carlo (MCMC) algorithm to constrain process parameters in LPJ-GUESS model using CH4 eddy-covariance flux observations from 14 different natural boreal, temperate, and arctic wetlands. The objective is to derive a single set of calibrated parameter values. The calibrated parameter values are then used in th

How to think about a place not yet : Studies of affordance and site-based methods for the exploration of design professionals' expectations in urban development processes

ABSTRACTAs a part of a democratic demand for transparency in urban development processes it is important that design professionals hold the ability to scrutinise their own work process, and at certain stages let go of predefined ideas of future realities. This work revolves around how design professionals perceive options for design in such situations. A basic assumption in this work is that a des