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The dispersion of repolarization in patients with ventricular tachycardia. A study using simultaneous monophasic action potential recordings from two sites in the right ventricle

The role of increased dispersion of repolarization in the genesis of torsade de pointes and ventricular fibrillation has been well recognized generally, but not in the genesis of monomorphic ventricular tachycardia (VT). Monophasic action potentials (MAP) were therefore recorded simultaneously from the right ventricular (RV) apex (RVA) and outflow tract (RVOT) during sinus rhythm, RV pacing and pr

Effect of dofetilide on cardiac repolarization in patients with ventricular tachycardia. A study using simultaneous monophasic action potential recordings from two sites in the right ventricle

Monophasic action potentials (MAP) were simultaneously recorded from the right ventricular (RV) apex (RVA) and the outflow tract (RVOT) before and after an infusion of dofetilide in 10 patients with documented ventricular tachycardia. After the drug infusion, the MAP duration (MAPd), repolarization time, and corrected QT interval were significantly prolonged during sinus rhythm, RV pacing, and RV

Urban underwater ERT for site investigation in lake Mälaren, Sweden

An underwater ERT survey was made along a planned road tunnel for The Stockholm Bypass Project (Förbifart Stockholm). The aim was to assess the ability to identify variations in the depth of the bottom sediments, as well as variations in rock quality and the possible presence of weak zones in the rock. Reference data from a seismic survey and geotechnical drilling was used for evaluation the resul

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction

The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C-terminal heterodimerization (PasB) domains. Taking advantage of the presence of several cysteine res

Observations made on the museums in Portici and on the Vesuvian sites by two Swedish professionals in 1756 and 1768, respectively

This article presents two formerly unedited travelaccounts, transcribed from the Swedish manuscripts and translated into English, narrating visits to Herculaneum, the Herculanense Museum and Pompeii, by Georg Fröman, Royal maçon, and Johan Tobias Sergel, sculptor, respectively. The texts are commented and put in historical context. Sergel's thorough accout of the Museum is read in parallel with th

An integrated approach to design site specific distributed electrical hubs combining optimization, multi-criterion assessment and decision making

An integrated approach is presented in this study to design electrical hubs combining optimization, multi-criterion assessment and decision making. Levelized Energy Cost (LEC), Initial Capital Cost (ICC), Grid Integration Level (GI), Levelized CO2 emission (LCO2), utilization of renewable energy, flexibility of the system, loss of load probability (LOLP) are considered as criteria used to assess t

Fracture mapping using seismic amplitude variation with offset and azimuth analysis at the Weyburn CO2 storage site

Cap rock integrity is an essential characteristic of any reservoir to be used for long-term CO 2 storage. Seismic AVOA (amplitude variation with offset and azimuth) techniques have been applied to map HTI anisotropy near the cap rock of the Weyburn field in southeast Saskatchewan, Canada, with the purpose of identifying potential fracture zones that may compromise seal integrity. This analysis, su