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Objective: To study the effects and serum levels of glibenclamide (Gb) and its active metabolites in patients on chronic Gb medication on different daily doses. Material and methods: Fifty patients with type 2 diabetes on regular Gb therapy (1.75-14.0 mg daily). Blood samples were taken immediately before and 90 min after regular Gb intake. A standardized breakfast was served 30 min after drug int

BACKGROUND:Osteochondral fractures are often seen on magnetic resonance imaging (MRI) of acutely injured knees, but their existence has gained little interest because of a lack of knowledge of their relation to treatment options and outcome. It is not clear whether acute phase synovial fluid (SF) concentrations of cartilage and bone markers and proinflammatory cytokines are different between traum

Purpose: alpha-Melanocyte stimulating hormone (alpha-MSH; Fluka Chemie AG, Geneva, Switzerland) and oxytocin induce erection in rats after intracerebroventricular administration. We studied possible interactions of alpha-melanocyte stimulating hormone with mechanisms pertaining to oxytocin or nitric oxide. Materials and Methods: We used 78 anesthetized male Sprague-Dawley rats. Catheters were impl

Objectives. Systemic sclerosis (SSc) is heterogenous. The objectives of this study were to evaluate the purpose, strengths and limitations of existing SSc subset criteria, and identify ideas among experts about subsets. Methods. We conducted semi-structured interviews with randomly sampled international SSc experts. The interview transcripts underwent an iterative process with text deconstructed t

Carbonyl exchange between [MX3(13CO)]–(MX = PdCl, PtCl or PtBr) and 12CO has been studied by IR and 13C NMR spectroscopies as a function of temperature. The exchange is first-order in both CO and complex concentration, and the activation entropies are negative, suggesting an associative reaction mechanism. There is a small solvent effect, but no chloride dependence. Activation parameters and rate Carbonyl exchange between [MX(3)((CO)-C-13)](-) (MX = PdCl, PtCl or PtBr) and (CO)-C-12 has been studied by IR and C-13 NMR spectroscopies as a function of temperature. The exchange is first-order in both CO and complex concentration, and the activation entropies are negative, suggesting an associative reaction mechanism. There is a small solvent effect. but no chloride dependence. Activation para

Title The social media paradox How social media and influencers affect consumers’ perception of quality of life Course Code BUSN39 Global Marketing Authors Elisabet Lund & Paulina Haux Supervisor Peter Svensson Keywords Social media, Influencers, Conspicuous Consumption, Quality of Life and Consumer Behavior Purpose The purpose of this study is to investigate how consumers perceive the co

Det svenska straffrättsliga systemet bygger på att endast fysiska personer kan begå brott och straffas för dessa. För näringsidkare, såväl fysiska som juridiska personer, har det istället införts särskilda sanktioner såsom företagsbot. Någon särskild reglering av företagsbotsprocessen och näringsidkarens processuella rättigheter vid en talan om företagsbot har däremot inte införts. Samtidigt uppstThe Swedish criminal justice system is based on the fact that only physical persons can commit crimes and be punished for them. For traders, both physical and legal persons, special sanctions such as a corporate fine have been introduced. However, no special regulations of neither the corporate fine procedure nor the procedural rights for traders, when pursuing criminal charges of a corporate fine

Unga lagöverträdare har sedan länge särbehandlats i det svenska påföljdssystemet. Den som begår brott innan 21 års ålder särbehandlas idag både beträffande straffmätningen och påföljdsvalet. Bland annat får den unge lagöverträdaren sitt straff reducerat genom den så kallade straffrabatten. I december 2018 utkom ungdomsreduktionsutredningen med ett förslag om slopad straffrabatt för unga lagöverträYoung offenders have long been treated differently than adult offenders in the Swedish penal system. Anyone who commits crimes before the age of 21 is today treated differently both in terms of the sentencing measure and the choice of penalty. Among other things, the young offenders gets their sentence reduced by the so-called “penalty discount”. In December of 2018 a government department issued

The forest fire that started in the vicinity of Sala in Västmanland 31 July 2014 ended up in being considered to be the biggest forest fire in Sweden for decades. Crisis management as we knew it got a punch on its nose so to speak. Municipalities, fire departments as well as governmental organizations got involved in something they never handled before and maybe for the first time they all had to

Domstolen har till uppgift att vid bevisvärderingen ta ställning till vad som är bevisat. Som huvudregel är det parterna som bär ansvaret för att det presenteras tillräckligt med bevisning. Enligt den grundläggande omedelbarhetsprincipen får rätten endast grunda avgörandet på sådant som förekommit vid huvudförhandlingen. Det finns dock undantag från kravet på bevisning och omedelbarhet. Domstolen The court determines what has been proved in a case by an evaluation of evidence. As a main principle, the parties are responsible for presenting sufficient evidence. According to the principle of immediateness the judgement shall be based solely on the material that has been presented at the main hearing. However, there are exceptions to the requirement of proof and the principle of immediateness

Syftet med studien var att undersöka hur biståndshandläggare och kuratorer, som möter äldre i sitt dagliga arbete, resonerar kring samverkan mellan socialtjänst och hälso– och sjukvården när det kommer till äldres psykiska ohälsa. Studien var av kvalitativ karaktär och innefattade sex semi-strukturerade intervjuer med tre biståndshandläggare inom äldreomsorgen och tre kuratorer inom hälso- och sju

Gällande entreprenadarbeten torde det vara vanligt förekommande att beställaren påtalar fel som denne vill att entreprenören ska avhjälpa. För att en part ska kunna aktualisera en påföljd vid påstått kontraktsbrott krävs enligt branschavtalet AB 04, precis som enligt allmän förmögenhetsrätt i övrigt, att en reklamation företas. Syftet med uppsatsen är därför att undersöka hur beställarens påkallanWhen it comes to contract work in the construction sector it is common that the client points out faults that he wants the contractor to rectify. For a party to be able to enforce a sanction in the event of an alleged breach of contract, the branch regulation AB 04 prescribes, just as according to general property law, that a complaint is made. The purpose of the thesis is therefore to investigate

Background: The aim in the thesis is to study diagnostic issues, clinical features, therapy, and prognosis in selected demyelinative disorders of the nervous system: optic neuritis (ON), primary progressive MS (PPMS), and tumefactive MS (a very rare acute demyelinating disorder). Methods: From an initial cohort of 110 patients with ON collected 19 to 31 years ago, a new follow-up survey was cond

BACKGROUND: Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clinical trials. Because the vast majority of women with positive cytology are also HPV DNA positive, screening strategies that use HPV DNA testing as the primary screening test may be more effective. METHO

Political institutions are keen to use the best available scientific knowledge in decision-making. For environmental policy, relevant scientific evidence can be complex and extensive, so expert judgment is frequently relied upon, without clear links to the evidence itself. We propose a new transparent process for incorporating research evidence into policy decisions, involving independent synopsis

Här behandlas Sveriges förbindelser med andra politisk-territoriella enheter, frånmedeltidens dynastiska unioner över de tidigmoderna konglomeratstaterna till1800-talets union av två nationalstater. Med hjälp av befintlig forskning fokuserasstatens växlande sammansättning och vikten av att skilja mellan riket och staten.Ett sådant perspektiv visar nya aspekter och ställer frågor som ett traditioneDuring most of the period from 1319 to 1905, the kingdom of Sweden formed part of a larger state, either through union with other states or through the possession of provinces that were not part of the kingdom proper. This is a neglected theme in Swedish historiography, where Sweden is described as a trans-historical entity, sometimes larger and sometimes smaller than the present state but still b

Fedorowski A, Hedblad B, Engstrom G, Gustav Smith J, Melander O (Department of Clinical Sciences, Lund University, Malmo; and Skane University Hospital, Malmo, Sweden). Orthostatic hypotension and long-term incidence of atrial fibrillation: the Malmo Preventive Project. J Intern Med 2010; 268: 383-389. Objectives. Orthostatic hypotension (OH), a common manifestation of autonomic dysfunction, has b

The effects of nitrogen (N) fertilization (0-150 kg N ha(-1) year(-1) since 1865) and pH (3.3-7.4) on fungal and bacterial growth, biomass and phospholipid fatty acid (PLFA) composition were investigated in grassland soils from the 'Park Grass Experiment', Rothamsted Research, UK. Bacterial growth decreased and fungal growth increased with lower pH, resulting in a 50-fold increase in the relative