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Looking back over 30 years of Swedish health care, professor Saltman examines structural changes in the Swedish health care sector. This is a very welcome contribution to the literature, and it makes good sense – institutional change is often a slow process, and it may take considerable time before the effects can be fully appreciated. Saltman’s paper provides a useful analytical overview of thre
Popular Abstract in Swedish Kvantprickar är objekt där elektroner är instängda i en mycket liten volym (av storleksordningen 100 nanometer i varje riktning). I den här avhandlingen har vi studerat kvantprickar definierade i nanotrådar av halvledarmaterial. Nanotrådarna kan vara flera mikrometer långa men samtidigt mycket tunna (mindre än 100 nanometer eller 0,1 mikrometer). Vi har skapat kvantpriThis thesis focuses on electrical transport in semiconductor InAs nanowires grown by chemical beam epitaxy. Initially, transport length scales of homogeneous InAs n-type nanowires are characterized by low-temperature magnetoconductance measurements. The measurements show phase-coherent conductivity corrections. By fitting the data, we find the nanowire mean-free path to be 50 nm and the phase-cohe
Microorganisms in soil are commonly limited by available substrate, and removing the limitation will increase activity and growth, with predictable dynamics in growth. The initial phase with a lag period (λ) will usually be followed by exponential growth (also called log phase, with growth rate μ). These two growth phases may be differently affected by environmental conditions, like temperature an
Background: Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim of this study was to examine in vivo associations between tau pathology, quantified with [18F]flortaucipir PET in regions corresponding to Braak stages, and atrophy across the Alzheime
IMPORTANCE Prostate cancer commonly metastasizes to bone, and bone metastases are associated with pathologic fractures, pain, and reduced survival. Bone disease is routinely visualized using the technetium Tc 99m(99mTc) bone scan; however, the standard interpretation of bone scan data relies on subjective manual assessment of counting metastatic lesion numbers. There is an unmet need for an object
Deoxygenation affects many continental shelf seas across the world today and results in increasing areas of hypoxia (dissolved oxygen concentration ([O2]) <1.4 ml/L). The Baltic Sea is increasingly affected by deoxygenation. Deoxygenation correlates with other environmental variables such as changing water temperature and salinity and is directly linked to ongoing global climate change. To place t
The European Union's Natura 2000 (N2000) is among the largest international networks of protected areas. One of its aims is to secure the status of a predetermined set of (targeted) bird and butterfly species. However, nontarget species may also benefit from N2000. We evaluated how the terrestrial component of this network affects the abundance of nontargeted, more common bird and butterfly specie
This doctoral thesis consists of four independent research papers. All papers are empirical and cover the area of financial market risk, with a particular focus on systemic risk and volatility in financial markets.The first paper analyzes the joint effect of centrality and other characteristics that are essential in determining banks’ systemic importance. Specifically, centrality is treated as a m
Remediation of soil contaminated with cadmium (Cd) and lead (Pb) is critical for tobacco production. Silicon (Si) fertilizer can relieve heavy metal stress and promote plant growth, however, it remains unknown whether fertilization with Si can mitigate the effects of Cd and Pb on tobacco growth and alter microbial community composition in polluted soils. Here we assessed the effect of two organic
Land-use change affects both the quality and quantity of soil organic carbon (SOC) and leads to changes in ecosystem functions such as productivity and environmental regulation. Future changes in SOC are, however, highly uncertain owing to its heterogeneity and complexity. In this study, we analyzed the outputs of simulations of SOC stock by Earth system models (ESMs), most of which are participan
Background: The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study. Methods: Targeted mass spectrometry metabolomics
Popular Abstract in Swedish Acceleratormasspektrometri, AMS, är en relativt ny metod för att bestämma extremt låga koncentrationer av såväl radioaktiva som stabila atomer. Metoden innebär att man med kärnfysikalisk teknik räknar atomerna en och en. De främsta fördelarna med AMS, jämfört med konventionella metoder, är att mycket små provmängder kan analyseras och att mättiden är kort. Mängden av eAccelerator mass spectrometry (AMS) is a highly sensitive method for counting atoms and it is used for detecting very low concentrations of both radionuclides and stable isotopes in small samples. The two major advantages of the AMS method are that the required amount of sample material is very small, but also that the efficiency is rather high, it takes less than an hour to analyse a sample. The
Vast amounts of resources extracted through the times are in today’s built environment, with only an estimated 20-30% of building material recycled or reused and the sector accounting for over 35% of the EU’s total waste generation. Buildings are also responsible for 25-40% of all global carbon dioxide emissions. Circular Economy (CE) refers to the better management of resources and waste by closi
BACKGROUND Anterior cruciate ligament (ACL) injury of the knee is common in young active adults and often has severe and sometimes lifelong consequences. The clinical management of this injury remains debated. A prior trial of early versus delayed optional ACL repair showed no differences in outcomes at 2 years. METHODS We present the 11-year follow-up of a randomized clinical trial involving 121
BACKGROUND: Patients with diabetes have increased rates of major adverse cardiac events (MACEs). We hypothesized that this is explained by diabetes-associated differences in coronary plaque morphology and lipid content. METHODS: In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), 898 patients with acute myocardial infarction with or without ST-segme
Popular Abstract in Swedish Fosterövervakning under förlossningen är standard inom förlossningsvården. Målet är att identifiera avvikande händelser och då speciellt syrebrist hos fostret. Sedan början på sjuttiotalet har vågformsanalys av foster EKG studerats ur fysiologisk, klinisk och signal synpunkt. Vågformen hos ett EKG innehåller mer information än bara R-R intervallet i ett EKG dvs konventiWaveform analysis of the fetal electrocardiogram has been studied since the early seventies from both physiological, signal processing and clinical aspects. It has been found to contain more useful information than the mere detection of RR-intervals (fetal heart rate), e.g., the ST-segment giving evidence of the ability of fetal myocardium to respond to the stress of labor. In the Swedish RCT, STA
The structural heterogeneity of tumor tissue can be probed by diffusion MRI (dMRI) in terms of the variance of apparent diffusivities within a voxel. However, the link between the diffusional variance and the tissue heterogeneity is not well-established. To investigate this link we test the hypothesis that diffusional variance, caused by microscopic anisotropy and isotropic heterogeneity, is assoc
The Benguela Upwelling System (BUS), located between 30 and 20°S, is one of the fundamental high-productivity systems of the world ocean. The BUS has previously been studied in terms of primary productivity and ecology over glacial-interglacial timescales; however, the response and coupling with the benthic environment have received little attention. Here, for the first time, we present a high-res
Amyloid beta (Aβ) proteins are a group of proteins able to form fibrillar aggregates that are linked to the adverse neurological effects seen in Alzheimer’s disease [11]. The molecular mechanisms that lead to the Aβ aggregation are complex processes, and efforts to understand them are being made by investigating the kinetics and thermodynamic properties of the protein. The solubility of the protei
Tänk dig en värld där din röst är nyckeln till allt – från att låsa upp dörrar till att logga in på ditt bankkonto. Denna teknik, kallad röstverifiering, används redan i stor skala för att identifiera personer genom unika egenskaper i deras röst. Men tekniken har sina begränsningar. Bullriga miljöer, korta inspelningar och språkliga skillnader kan göra systemen mindre pålitliga. Hur kan robustheteThis thesis explores advancements in Automatic Speaker Verification (ASV) by examining the impact of multiple speaker enrollments and introducing Adaptive Neural Probabilistic Linear Discriminant Analysis (Adaptive NPLDA). Modern ASV combines front-end feature extraction, using state-of-the-art methods based on Deep Neural Networks (DNNs), such as the ReDimNet architectures, with back-end modeling
