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The Limits of Thought & the Mind-Body Problem

This paper gives an account of Colin McGinn's essay: "Can We Solve the Mind-Body Problem?". McGinn's answer to his own essay title is that the problem is forever beyond us due to the particular nature of our cognitive abilities. The present author offers a number of criticisms of the arguments which support this conclusion

RURITAGE Deliverable 3.4: RURITAGE Heritage-led regeneration plans for Replicators

This deliverable summarizes the results of the co-development of innovative heritage-led regeneration plans in Replicators and builds on findings and activities coming from WP1-4 and WP7. RURITAGE’s 6 Replicators represent six very diverse rural areas in Europe and beyond (Austria, Norway, Germany, Slovenia, Italy and Turkey) and are acting as the main laboratories to test the RURITAGE approach. B

Local volatility changes in the Black-Scholes model

In this paper we address a sensitivity problem with financial applications. Namely the study of price variations of different contingent claims in the Black-Scholes model due to changes in volatility. This study needs an extension of the classical Vega index, i.e. the price derivative with respect to the constant volatility, which we call the local Vega index (lvi). This index measures the importa

Spending, saving, or investing? : Risk management in sixteenth-century Dutch households

In the past one of the main challenges to households was that of coping with adversity. War, plague, famine, and flood were a constant threat, and could reduce what little improvements families had made in productivity. Economic growth therefore required a means of absorbing external adversities. To see how well late medieval households coped with adversity, this investigation focuses on the house

Treatment with amino acids in serine deficiency disorders

Serine deficiency disorders are rare defects in the biosynthesis of the amino acid L-serine. At present two disorders have been reported: 3-phosphoglycerate dehydrogenase deficiency and 3-phosphoserine phosphatase deficiency. These enzyme defects lead to severe neurological symptoms such as congenital microcephaly and severe psychomotor retardation and in addition in patients with 3-phosphoglycera

Amino acid synthesis deficiencies

In recent years the number of disorders known to affect amino acid synthesis has grown rapidly. Nor is it just the number of disorders that has increased: the associated clinical phenotypes have also expanded spectacularly, primarily due to the advances of next generation sequencing diagnostics. In contrast to the “classical” inborn errors of metabolism in catabolic pathways, in which elevated lev