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Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism

Autism spectrum disorder (ASD) is a common neurodevelopmental condition characterized by marked genetic heterogeneity. Recent studies of rare structural and sequence variants have identified hundreds of loci involved in ASD, but our knowledge of the overall genetic architecture and the underlying pathophysiological mechanisms remains incomplete. Glycine receptors (GlyRs) are ligand-gated chloride

Spending, saving, or investing? : Risk management in sixteenth-century Dutch households

In the past one of the main challenges to households was that of coping with adversity. War, plague, famine, and flood were a constant threat, and could reduce what little improvements families had made in productivity. Economic growth therefore required a means of absorbing external adversities. To see how well late medieval households coped with adversity, this investigation focuses on the house

Amino acid synthesis deficiencies

In recent years the number of disorders known to affect amino acid synthesis has grown rapidly. Nor is it just the number of disorders that has increased: the associated clinical phenotypes have also expanded spectacularly, primarily due to the advances of next generation sequencing diagnostics. In contrast to the “classical” inborn errors of metabolism in catabolic pathways, in which elevated lev

RURITAGE Deliverable 3.4: RURITAGE Heritage-led regeneration plans for Replicators

This deliverable summarizes the results of the co-development of innovative heritage-led regeneration plans in Replicators and builds on findings and activities coming from WP1-4 and WP7. RURITAGE’s 6 Replicators represent six very diverse rural areas in Europe and beyond (Austria, Norway, Germany, Slovenia, Italy and Turkey) and are acting as the main laboratories to test the RURITAGE approach. B

Process Control in Practice

This book covers the most important topics that people working as process control engineers and plant operators will encounter. It focuses on PID control, explains when to use P-, PI-, PD- or PID control as well as PID tuning and includes difficult to control process nonlinearities such as valve stiction or sensor problems. The book also explains advanced control strategies that are necessary when

Standardization of the Compass Neuropils of the Australian Bogong Moth, Agrotis infusa

Every summer the Australian Bogong moth migrates from southern Queensland to the Australian Alps in southern New South Wales. Other migrants such as the monarch butterfly use a time-compensated sun compass. However, the Bogong is nocturnal and only has access to skylight cues such as the moon, polarized light or the Milky Way. Since these are considerably unreliable only being visible short period

Climate change effects on growth and reproductive development of oilseed rape (Brassica napus L.)

The growing world population will demand an increase in agriculture production to sustain the consumption of food and demands for bioenergy. Nevertheless, negative impacts on crop production have been observed due to effects of climate change, which threatens our ability to sustain future demands. Yield reductions due to warmer conditions and more frequent extreme weather events were increasingly