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ALK mutations occur in 10% of primary neuroblastomas and represent a major target for precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra-high-risk phenotype resulting in very poor patient prognosis. To open up opportunities for future precision drugging, a deeper understanding of the molecular consequences of constitutive ALK signaling and its relationship to
Background: Elevated serum levels of growth differentiation factor-15 (GDF-15), is an established risk factor for a range of cardiovascular diseases.We aimed to evaluate the predictive value of plasma GDF-15 as a biomarker for secondary cardiovascular events (CVE) in patients with atherosclerosis undergoing carotid endarterectomy (CEA). Secondly, we determined whether plasma GDF-15 was associated
Action plan to counteract victimisation and discrimination at the Department of Psychology 16 DECEMBER 2016 2 DEPARTMENT OF PSYCHOLOGY 1. Introduction The action plan aims to clarify the rules that apply to employees of the Department of Psychology and how to deal with conflicts and situations that involve victimisation and discrimination or bullying, harassment/sexual harassment. Victimisation re
https://www.psy.lu.se/en/sites/psy.lu.se.en/files/actionplan2016.pdf - 2026-05-08
Reading list for SGR020F Environment and Sustainable Development in the MENA Region, 7.5 credits, third cycle Page 1 of 4 READING LIST Reg. No. U 2023/301 2023-06-14 Reading list for SGR020F Environment and Sustainable Development in the MENA Region, 7.5 credits, third cycle The reading list was approved by the Research Studies Council 14 June 2023 and is valid from the autumn semester 2023. Books
Methylglyoxal (MGO) is an endogenous toxin, mainly produced as a by-product of glycolysis that has been associated to aging, Alzheimer's disease, and inflammation. Cell culture studies reported that MGO could impair the glyoxalase, thioredoxin, and glutathione systems. Thus, we investigated the effect of in vivo MGO administration on these systems, but no major changes were observed in the glyoxal
Background: The neotropical anopheline mosquito Anopheles darlingi is a major malaria vector in the Americas. Studies on mosquito-associated microbiota have shown that symbiotic bacteria play a major role in host biology. Mosquitoes acquire and transmit microorganisms over their life cycle. Specifically, the microbiota of immature forms is largely acquired from their aquatic environment. Therefore
BACKGROUND: [Corrected] Clinical assessment is not always sufficient to predict postoperative (PO) cardiac complications. B-type natriuretic peptide (BNP) has an important prognostic value in patients with heart failure. Its value as a predictor of events in orthopedic surgeries has not yet been tested.OBJECTIVE: To assess the value of BNP in predicting cardiac complications in the PO period of or
Hydrogels for biomedical applications have been widely studied once they are able to enhance the wound-healing process, as well as facilitate the controlled release and loading of drugs. In this context, Pluronic F127 (PF127) has a major role as it was shown to have exceptional versatility, once it holds unique gelation properties, as it is thermoreversible and is liquid in lower temperatures, and
Inborn errors of metabolism (IEMs) are characterized by deficits in metabolic enzymes as a result of an inherited disease, leading to the accumulation or decreased excretion of proteins, carbohydrates and lipids. Although IEMs are often diagnosed during childhood, adolescent and adult onset variants may be accompanied by less somatic and more psychiatric manifestations, which often hampers recogni
Synaptic gain control and information storage in neural networks are mediated by alterations in synaptic transmission, such as in long-term potentiation (LTP). Here, we show using both in vitro and in vivo recordings from the rat cerebellum that tetanization protocols for the induction of LTP at parallel fiber (PF)-to-Purkinje cell synapses can also evoke increases in intrinsic excitability. This
PURPOSE: The aim of this study was to define the scales and test the validity, reliability, and sensitivity of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-H&N35, a questionnaire designed to assess the quality of life of head and neck (H&N) cancer patients in conjunction with the general cancer-specific EORTC QLQ-C30. PATIENTS AND
Objective: To evaluate the safety and performance of Alione Hydrocapillary dressing (Coloplast A/S) in the management of highly exuding chronic venous leg ulcers and compare it with two hydropolymer dressings, Tielle and Tielle Plus (Johnson & Johnson). Method: A comparative clinical trial was conducted on 97 patients with an ankle brachial pressure index ?0.8 and a highly exuding leg ulcer. U
Background: Termites of the subfamily Macrotermitinae live in a mutualistic symbiosis with basidiomycete fungi of the genus Termitomyces. Here, we explored interaction specificity in fungus-growing termites using samples from 101 colonies in South-Africa and Senegal, belonging to eight species divided over three genera. Knowledge of interaction specificity is important to test the hypothesis that
Postdoctoral fellow Contact details Email: veronica [dot] hederstrom [at] mgeo [dot] lu [dot] seOrganisation Biodiversity and Conservation Science Service point: 50 WebpageVeronica Hederströms profile in Lund University research portalOther affiliations Affiliated Department of Earth and Environmental Sciences (MGeo) Member of Strategic Research Area BECC: Biodiversity and Ecosystem services in a
https://www.cec.lu.se/veronica-hederstrom - 2026-05-08
Microsoft Word - Bianchi_SALC6_abstract.docx Ivana Bianchi The perception and cognition of opposites Since time immemorial, it has been recognized in various scientific domains that opposition/contrariety (here used as interchangeable terms) represent a primal relationship in the human cognitive architecture. Early philosophers discussed its fundamental role for many concepts (e.g. pre-socratic ph
https://konferens.ht.lu.se/fileadmin/user_upload/sol/ovrigt/konferens_SALC6/PDF/Bianchi_SALC6_abstract.pdf - 2026-05-07
Centre for Mathemat ica l Sc iences Div i s ion of Mathematics and Numer ica l Analy s i s Course Analysis for MATB25, Spring 2023 Course Information Lecturer: Anna Torstensson Teaching assistants: Thomas Munn Number of students: 13 newly registered and 9 re-registered. 9 students answered the course evaluation. Examination Project: 17 students passed. Oral examination: 11 students passed. Written
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/VT2023/MATB25FMAB75VT23.pdf - 2026-05-07
A female figurine from the basal Aurignacian of Hohle Fels Cave in southwestern Germany LETTERS A female figurine from the basal Aurignacian of Hohle Fels Cave in southwestern Germany Nicholas J. Conard1 Despite well over 100 years of research and debate, the origins of art remain contentious1–3. In recent years, abstract depictions have been documented at southern African sites dating to 75 kyr b
https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_ccs/Conard_Venus_Nature_2009.pdf - 2026-05-07
