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Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by upregulation of ribosome biogenesis during G1/S arrest. This unexpected EMT feature is independent of species and initiating signal, and is accompanied by

Forests provide grounds for human well-being through direct material, indirect environmental, and immaterial contributions. Here, we analyze the example of Hispaniola to understand reasons for (un)sustainable forest use. We pursue a dynamic comparative case study of the island's two countries from a political ecology perspective. From the literature, we derive a set of socio-economic hypotheses fo

The majority of ectotherms mature at a larger size at lower rearing temperatures. Although this temperature-size rule is well established, a general explanation for this phenomenon has remained elusive. In this article, we address the problem by exploring the proximate and ultimate reasons for why a temperate grasshopper, Chorthippus brunneus, is an exception to the temperature-size rule. Using a

Post-normal science (PNS) has long advocated the inclusion of stakeholders in scientific processes where there is uncertainty, urgency and high stakes. Increasingly, however, such conditions have become recognised as the norm. Using the theoretical perspective of PNS, we examine the interactions between public objection, unstable coalition politics and uncertain environmental assessment knowledge

It has been proposed that formation of abdominal aortic aneurysm (AAA) is part of a systemic arterial dilatative disease. However, arteries in the upper extremity are scarcely studied and it remains unclear whether both muscular and elastic arteries are affected by the proposed systemic arterial dilatation. The aim of this study was to investigate diameter and stiffness of muscular and elastic art

In the us, test score gaps by socioeconomic status and race increase with city size. This paper examines to what extent residential sorting on school quality can explain this fact. We combine 15 years of data on public elementary school studentsin North Carolina with geocoded school locations and proxy city size with a measure of school density in a local labor market. Assortative matching between

Induced pluripotent stem cells (iPSCs) can in principle differentiate into any cell of the body, and have revolutionized biomedical research and regenerative medicine. Unlike their human counterparts, mouse iPSCs (miPSCs) are reported to silence transposable elements and prevent transposable element-mediated mutagenesis. Here we apply short-read or Oxford Nanopore Technologies long-read genome seq

Human induced pluripotent stem cells (hiPSCs) are capable of unlimited proliferation and can differentiate in vitro to generate derivatives of the three primary germ layers. Genetic and epigenetic abnormalities have been reported by Wissing and colleagues to occur during hiPSC derivation, including mobilization of engineered LINE-1 (L1) retrotransposons. However, incidence and functional impact of

The effects of peptidolysis during early cheese ripening were studied in a low-fat (10% fat), round-eyed, semi-hard cheese using gel permeation chromatography and determinations of N content in cheese extracts. Addition of a heat-treated culture of Lactobacillus helveticus enhanced the peptidolytic activity even during the first weeks of cheese ripening. An aminopeptidase was found to have the nec

Amidst criticism of the concept of “the learning organisation” there is a perspective which is both critical of, and open to, innovative ways of developing the notion of a learning organisation. This article contributes to this perspective by examining the learning practices of a feminist NGO which operates across Southern Africa. The ways in which this NGO has interpreted the idea of a learning o

Static program analysis plays a crucial role in ensuring the quality and security of software applications by detecting bugs and potential vulnerabilities in the code. Traditionally, these analyses are performed offline, either as part of the continuous integration/continuous deployment pipeline or overnight on the entire repository. However, this delayed feedback disrupts developer productivity,

Craft has been a steady adversary to the proliferation of industrialization. As an imaginary of embodied work, mainly driven by intrinsic motivation and by a strive for excellence, craft is increasingly re-emerging in discussions on improving current forms of work. A common theme across research on craft is its potential to address alienation as one of the main pathologies of modern work. We study

In the fields of behavioural and psychological research, pupil size and skin conductance are two variables that provide useful information about a participant’s state of mind at a given moment. Both variables are involuntary indicators of psychophysiological responses such as alertness, arousal, or focus. Pupil size is commonly measured with a video-based eye tracker, and skin conductance is measu

The main objective of Work Package 4 was to provide quantifiable evidences of the potential role of CNH as a driver for sustainable growth. To do this, WP4 has been monitoring over the last 2.5 years the performance of the deployed Action Plans (or regeneration schemes) in the 6 initial Replicators (Rs), and the 9 Additional Replicators (ARs) included in the last phase of the project. Performance’

The podocyte is a specialized cell type critically involved in maintaining the selective filtration barrier of the kidney. Podocytes are primary or secondary targets for a multitude of kidney diseases. Despite intense investigation, the transcriptome and proteome of human podocytes remain incompletely characterized. Here, we analyzed publicly available RNA-Seq data from human kidneys (n = 85) to c

Rural communities tell us the story of a thousand of years of collaboration between nature, culture and humans. The current Covid-19 pandemic is considerably threating rural areas, posing challenges exacerbated by low available financial resources, not easily accessible health services and greater isolation. Rural areas are also considered safe shelters characterized by better daily living conditi