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Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemi
Recension av Antereo Holmila, Reporting the the Holocaust in the British, Swedish and Finnish Press 1945–50.
Genome sequencing can identify individuals in the general population who harbor rare coding variants in genes for Mendelian disorders1-7 and who may consequently have increased disease risk. Previous studies of rare variants in phenotypically extreme individuals display ascertainment bias and may demonstrate inflated effect-size estimates8-12. We sequenced seven genes for maturity-onset diabetes o
To validate cardiac output measurements by ultrasound dilution technology (COstatus monitor) against those obtained by a transit-time ultrasound technology with a perivascular flow probe and to investigate ultrasound dilution ability to estimate pulmonary to systemic blood flow ratio in children.
The German Federal Fiscal Court has in its decision from the 11th of December 2013 announced doubts of the constitutionality of a German national provision, including a treaty override, with the Constitution. This paper is aimed at shedding some light on the reasons for this decision, to give an outlook on the still pending decision of the highest German constituional court and to name influences
Energy efficient wireless devices is a trend that has been on the rise the last few years. Energy efficiency properties may fill a function in wireless sensor networks where the devices could run on coin-cell batteries and still last for years. To make sense of the sensor data collected, there is a requirement of accurate time synchronization in the network. This report focuses on investigating if
Social Media Analytic (SMA) is an emerging trend driven by practitioners to access and ana-lyze the increased volumes of user-generated content. The utilization of SMA provides organ-izations with the potential to improve customer insights, digital presence and foster customer relationships. However, despite the positive aspects, acquisition of an emerging technology presents both technical and op
I denna uppsats har jag utrett vilka kriterier som uppställs för att fastställa inre väpnad konflikt i svensk rätt. Jag undersöker också hur kriterierna fastställs även i EU-rätten och i den internationella humanitära folkrätten gällande inre väpnad konflikt då båda dessa områden starkt påverkar den inhemska tillämpningen av begreppet. Genom att undersöka framförallt Diakité-domen har jag konstateIn this thesis I have examined with which criteria internal armed conflict is established within Swedish law. I have also examined the EU-law and the international humanitarian law and which criteria is laid down to understand the Swedish law which is strongly influenced by these lawsystems. By examining especially the Diakité case I´ve found that Swedish case law differs from EU case law and the
Den digitala utvecklingen har skapat nya förutsättningar för hur individer och or-ganisationer kan interagera, där ett exempel är samskapande (eng. co-creation). Syftet med studien är att undersöka de drivkrafter och känslor som ligger bakom individens beslut till att delta i den specifika samskapandeformen rotation curation tillsammans med organisationer och hur detta skapar mening för individen.The digital evolution has created new ways for individuals and organizations to interact of which one example is co-creation. The purpose of this study is to exa-mine which motives and emotions that underlie an individual’s decision to parti-cipate in the specific form of co-creation called rotation curation together with an an organization and how this creates meaning for the individual. Further,
The high spin states in the Ce-139 nucleus have been studied by in-beam gamma-spectroscopic techniques using the reaction Te-130(C-12,3n)Ce-139 at E-beam=65 MeV. A gamma detector array, consisting of five Compton-suppressed Clover detectors was used for coincidence measurements. 15 new levels have been proposed and 28 new gamma transitions have been assigned to Ce-139 on the basis of gamma gamma c
This discussion paper, by a Working Group of INTIMATE (Integration of ice-core, marine and terrestrial records) and the Subcommision on Quaternary Stratigraphy (SQS) of the International Commission on Stratigraphy (ICS), considers the prospects for a formal subdivision of the Holocene Series/Epoch. Although previous attempts to subdivide the Holocene have proved inconclusive, recent developments i
Many bird species are able to replace accidentally lost feathers out of the normal moulting periods, but whether such replaced feathers are able to restore the original mechanical properties of the plumage has not been evaluated before. In this study we analysed the structure and mechanical behaviour of the original and replaced feathers of 12 blackcaps Sylvia atricapilla. Replaced feathers showed
Centuries of artificial selection have dramatically improved the yield of human agriculture; however, strong directional selection also occurs in natural symbiotic interactions. Fungus-growing attine ants cultivate basidiomycete fungi for food. One cultivar lineage has evolved inflated hyphal tips (gongylidia) that grow in bundles called staphylae, to specifically feed the ants. Here we show exten
The androgen receptor is a key transcription factor contributing to the development of all stages of prostate cancer (PCa). In addition, other transcription factors have been associated with poor prognosis in PCa, amongst which c-Myc (MYC) is a well-established oncogene in many other cancers. We have previously reported that the AR promotes glycolysis and anabolic metabolism; many of these metabol
Sugarcane bagasse was subjected to steam pretreatment impregnated with hydrogen peroxide. Analyses were performed using 2(3) factorial designs and enzymatic hydrolysis was performed at two different solid concentrations and with washed and unwashed material to evaluate the importance of this step for obtaining high cellulose conversion. Similar cellulose conversion were obtained at different condi
