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BACKGROUND: TKA generally has excellent long-term survivorship. When a new knee system supersedes a previous model, increased survivorship, improved functional performance, or both may be expected, because key areas of design modification are often targeted to address wear, stability, and the patellofemoral articulation. However, not all design changes are beneficial, and to our knowledge, knee ar

Grasslands are a prerequisite for rearing livestock, and livestock is the mainstay of people’s existence in drylands. As one Kenyan woman put it, “without grass there is no livestock, without livestock there is no life.” Based in the lowlands of Baringo County in Kenya’s Rift Valley, RAE (Rehabilitating Arid Environments) Ltd. has worked for 38 years to develop a successful socio-ecological model

A novel interferometric technique to measure small wedge angle of transparent windows is proposed. The technique is based on the measurement of the shift of the interference pattern generated by two sheared copies of a laser beam after crossing the optical wedge. A simple lens is used to combine the two beams in their focal plane and measurements are taken for different shears. It is not necessary

Ovarian cancer, often called the silent killer due to its diffuse symptoms at early stage, poor prognosis after treatments and high mortality, is also a heterogeneous disease consisting of different histological subtypes with potentially different origins. About 90% of all cases derive from epithelial cells and high-grade serous ovarian carcinoma (HGSOC) is the most common and aggressive form of e

Lorcaserin, which is a selective agonist of serotonin2C receptors (5-HT2CRs), is a new FDA-approved anti-obesity drug that has also shown therapeutic promise in other brain disorders, such as addiction and epilepsy. The modulation of dopaminergic function might be critical in the therapeutic effect of lorcaserin, but its exact effect is unknown. Here, we studied the effect of the peripheral admini

Cleveland (1979) is usually credited with the introduction of the locally weighted regression, Loess. The concept was further developed by Cleveland and Devlin (1988). The general idea is that for an arbitrary number of explanatory data points x_i the value of a dependent variable is estimated ŷ_i. The ŷ_i is the fitted value from a dth degree polynomial in x_i

Aims: In this article we explore the moderators of effectiveness of WISEteens (Web-based brief Intervention for SubstancE using teens), a fully automated web-based brief motivational intervention targeting risky substance use among adolescents. Based on previous studies, we examined the differential effects on drinking of sex, readiness to change, self-efficacy, alcohol risk status, and parental m

Introduction: Female surgeons remain a minority within the field of orthopaedics, particularly in certain specialties such as arthroplasty. There is no scientific evidence on whether the surgeon's sex affects the patient-reported outcome after orthopaedic surgery such as total hip arthroplasty (THA). We therefore aimed to investigate the association between surgeon sex and health-related quality o

Trials with automated mini buses (AV shuttles) are going on in many cities. According to game-theoretic reasoning, in mixed traffic normal road users will soon take advantage of the defensive driving style of the AV shuttles, and may eventually totally block their accessibility (Camara et al., 2018; Michieli & Badia, 2018; Millard-Ball, 2018). So far there are few studies on the interaction be

Adaptive phenotypic plasticity may improve the response of individuals when faced with new environmental conditions. Typically, empirical evidence for plasticity is based on phenotypic reaction norms obtained in reciprocal transplant experiments. In such experiments, individuals from their native environment are transplanted into a different environment, and a number of trait values, potentially i

The Ph.D. dissertation consists of three connected, yet independent research articles, which focus on the implementation of circular economy principles in public procurement. Motivated by a curiosity for dynamics in processes of implementation I chose to investigate how actors related to processes of public procurement can implement the circular economy principles as a default. The aim of the diss

Tilt table testing (TTT) has been used for decades to study short-term blood pressure (BP) and heart rate regulation during orthostatic challenges. TTT provokes vasovagal reflex in many syncope patients as a background of widespread use. Despite the availability of evidence-based practice syncope guidelines, proper application and interpretation of TTT in the day-to-day care of syncope patients re