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To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using

Low-dimensional narrow band gap III-V compound semiconductors, such as InAs and InSb, have attracted much attention as one of promising platforms for studying Majorana zero modes and non-Abelian statistics relevant for topological quantum computation. So far, most of experimental studies were performed on hybrid devices based on one-dimensional semiconductor nanowires. In order to build complex to

One of the hallmark findings from behavioral economics is that choices are sensitive to the context they are presented in. However, the strength of such 'framing effects' varies between studies, and some studies fail to find any effect at all. A long line of research has argued that the presence and size of framing effects depend to a large extent on whether people use higher or lower-level mental

Speciation is the process that generates biodiversity, but recent empirical findings show that it can also fail, leading to the collapse of two incipient species into one. Here, we elucidate the mechanisms behind speciation collapse using a stochastic individual-based model with explicit genetics. We investigate the impact of two types of environmental disturbance: deteriorated visual conditions,

This article explores how a series of heritage-driven renewal plans in the Swedish city Malmö dealt with a landscape deeply shaped by radical politics: Malmö People’s Park (Folkets Park). Arguing against notions of heritage where the past is essentially considered a malleable resource for present commercial or political concerns, we scrutinise plans for the People’s Park from the 1980s onward to e

Various modal methods are frequently used to investigate the vibration pattern in construction elements of a building in the low frequency range. The experimental determination of time average transmission and reflection coefficient has been developed for the large scale building structures. In this study, we investigate a mock up of a wall/floor junction. The wave approach is combined with the co

Abstract in French La sédation des patients neurochirurgicaux fait appel le plus souvent à une association hypnotique-analgésique. Leurs effets sur l'hémodynamique et le métabolisme cérébraux sont l'un des critères qui président au choix des produits. Les analgésiques utilisés seuls, ont peu d'effets sur le flux sanguin cérébral et la CMRO2. Certaines données de la littérature attribuent aux analg

An opportunity sample of 108 Chinese participants (n(male) = 51 and n(female) = 57; M-age = 29.34) was compared to a second opportunity sample of 98 Northern Irish participants (n(male) = 45 and n(female) = 53; M-age = 23.67) on levels of acculturation, self-efficacy and social support. The administered questionnaire contained three scales to measure the aforementioned constructs. The first was th

Waardenburg-Shah syndrome (Waardenburg syndrome type IV-WS4) is an auditory-pigmentary disorder that combines clinical features of pigmentary abnormalities of the skin, hair and irides, sensorineural hearing loss, and Hirschsprung disease (HSCR). Mutations in the endothelin-B receptor (EDNRB) gene on 13q22 have been found to cause this syndrome. Mutations in both alleles cause the full phenotype,

Diabetic nephropathy (DN) develops in about 40% of insulin-dependent type 1 diabetes mellitus (TlDM) patients, and is associated not only with diabetes duration and metabolic control, but also with a genetic predisposition. Constitutive alterations of cytoskeletal proteins may play a role in the development of DN. We investigated the expression of these proteins in cultured skin fibroblasts, obtai

Protein kinase B is known to mediate a number of biological responses to insulin and growth factors, its role in glucose uptake being one of the most extensively studied. In this paper, we have employed a recently described allosteric inhibitor of PKB, Akti, to clarify the role of PKB in lipid metabolism in adipocytes - a subject that has received less attention. Pretreatment of primary rat and 3T