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Human embryonic stem cells offer a potential unlimited supply for functional hepatocytes, since they can differentiate into hepatocyte-like cells displaying a characteristic hepatic morphology and expressing various hepatic markers. These cells could be used in various applications such as studies of drug metabolism and hepatotoxicity, which however, would require a significant expression of drug
Recent studies have highlighted the involvement of rare (<1% frequency) copy-number variations and point mutations in the genetic etiology of autism spectrum disorder (ASD); these variants particularly affect genes involved in the neuronal synaptic complex. The SHANK gene family consists of three members (SHANK1, SHANK2, and SHANK3), which encode scaffolding proteins required for the proper format
Uraemia is a strong risk factor for cardiovascular disease. Osteopontin (OPN) is highly expressed in aortas of uraemic apolipoprotein E knockout (E KO) mice. OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice. Uraemia was induced by 5/6 nephrectomy in E KO and in OPN and
Background and purpose: Pyruvate dehydrogenase complex deficiency is in up to 90% caused by pathogenic variants in the X-linked PDHA1 gene. We aimed to investigate female relatives of index patients with PDHA1-related disease to (i) describe the prevalence of female PDHA1 carriers, (ii) determine whether they had symptoms and signs, and (iii) delineate the associated phenotype. Methods: In a natio
Allergic contact dermatitis is reported among individuals using continuous glucose monitoring systems and insulin pumps. The aim of this study was to describe contact allergy patterns for allergens in the Swedish baseline series and medical device-related allergens among users. Contact allergy to baseline series allergens and isobornyl acrylate was compared between diabetes patients and dermatitis
In this paper, we explore contemporary regional development in a historic industrial region. Specifically, we unpack the influences of industrial history and culture, built up over several centuries, on contemporary regional development dynamics and issues. In doing so, we draw on an evolutionary perspective within economic geography and perspectives from deindustrialization studies to understand
This thesis sought to investigate how ISOs shaped their strategic narratives, linked to their reactions and actions against Russia, since the invasion of Ukraine in 2022. In addition, it also intends to shine light on how international sport activities can be used as a soft power tool in international politics. Using a combination of a case study and qualitative content analysis, it is revealed ho
Sustainability is one of the main communication challenges that organizations face in the 21st century, and as the digitalization of communication has increased, so have the visual aspects of sustainability communication. The subject is rather new in general and has only recently grown within sports organizations such as motorsports. Therefore, there is little research, knowledge, and understandin
Risk attitudes influence a wide range of financial decisions in the household, such as investments, consumption, and savings. It is, therefore, crucial to understand risk attitudes and how they change throughout the life cycle, in order to determine and predict economic behavior. In this study, we investigate the impact of changes in family structure on individuals' financial risk attitudes by
In this thesis a preliminary evaluation of the potential of a leghemoglobin (Lb) for the development of a blood substitute in humans, resembling hemoglobin (Hb) in red blood cells, was conducted. Leghemoglobin B (VfLbB), a gene from Vicia faba, was cloned into a pET-DEST42 vector, using the Gateway™ recombination technology. The recombinant vector containing VfLbB was sequenced and confirmed. Then
The nuclear reaction 10B(n,alpha)7Li* was utilised to develop a neutron detection system. This system has the purpose of being used to detect the thermal neutron radiation emitted by spent nuclear fuel, before it is transported to a final repository. This to investigate the content of the fuel-containing capsules, primarily to ensure non-proliferation of radioactive materials in the nuclear waste
The development and use of stretchable electronics is a relatively new research field. However, the use of these kinds of electronics could prove fruitful when seeking to improve medical sensors and equipment. Since the substrates and manufacturing methods used when making stretchable electronics allows them to be extremely thin, with a thickness in the μm range. At these thickness levels, the ele
Syftet med denna uppsats är att undersöka förekomsten av heteronormativitet i tre svenska historieläroböcker. Denna undersökning ska även bidra till en förståelse av heteronormativitet i den svenska skolan och ge ett perspektiv på vilkas historia som uppmärksammas i historieundervisning. Detta syfte uppnås genom att besvara följande frågeställningar: Hur förekommande är heteronormativiteten i de tThe aim of this essay is to study the presence of heteronormativity in three Swedish history textbooks. This study shall contribute towards an understanding of heteronormativity in Swedish schools and give insight into who the study of history prioritises. The aim will be fulfilled by answering the following questions: to what extent is heteronormativity present within the three history textbooks’
Genomic rearrangements larger than 50 bp are called structural variants. As a group, they affect the phenotypic diversity among humans and have been associated with many human disorders including neurodevelopmental disorder and cancer. Recent advances in whole genome sequencing (WGS) technologies have made it possible to identify many more disease-causing genetic variants relevant in clinical diag
This thesis is based on my interpretation of three particular visual examples that were created in relation to the racial tensions that were occurring at the time of their production. My visual examples are (1) the 2016 campaign advert commissioned by Operation Black vote (2) The music video I’m not Racist by the American rapper Joyner Lucas relaesed in 2017 (3) Sir Davey’s Proclamation Board to t
