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Early Weichselian palaeoenvironments reconstructed from a mega-scale thrust-fault complex, Kanin Peninsula, northwestern Russia

A section, almost 20 km long and up to 80 m high, through alternating layers of diamict and sorted sediments is superbly exposed on the north coast of the Kanin Peninsula, northwestern Russia. The diamicts represent multiple glacial advances by the Barents Sea and the Kara Sea ice sheets during the Weichselian. The diamicts and stratigraphically older lacustrine, fluvial and shallow marine sedimen

A meta-analysis of prior corticosteroid use and fracture risk

The relationship between use of corticosteroids and fracture risk was estimated in a meta-analysis of data from seven cohort studies of similar to42,000 men and women. Current and past use of corticosteroids was an important predictor of fracture risk that was independent of prior fracture and BMD.

Hydrolysis of galactolipids by human pancreatic lipolytic enzymes and duodenal contents

Monogalactosyldiacylglycerols (MGDG), digalactosyldiacylglycerols (DGDG) and sulfoquinovosyldiacylglycerols (SQDG) are major lipids in vegetable food. Their digestion and absorption are unknown. This study examines the hydrolysis of galactolipids in vitro with human duodenal contents, pancreatic juice, and purified human pancreatic lipases. Galactolipids were incubated with human duodenal contents

Immunoadsorption for removal of inhibitors: update on treatments in Malmo-Lund between 1980 and 1995

Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved treatment for patients with initial inhibitor tit

Posterior atlanto-axial dislocation in rheumatoid arthritis

Seven patients with rheumatoid arthritis and posterior atlanto-axial dislocation are presented. The patients were elderly women who had suffered with the disease a long time. In all cases earlier cervical radiographs were available, excluding any predisposing congenital anomaly. Fracture and arthritic destruction of the dens, of parts of the body of the axis, or of the anterior arch of the atlas p

Conflicting patterns of mitochondrial and nuclear DNA diversity in Phylloscopus warblers

Molecular variation is often used to infer the demographic history of species, but sometimes the complexity of species history can make such inference difficult. The willow warbler, Phylloscopus trochilus, shows substantially less geographical variation than the chiffchaff, Phylloscopus collybita, both in morphology and in mitochondrial DNA (mtDNA) divergence. We therefore predicted that the willo

Sacrifice, Conflict and the Foundation of Culture

In the wake of the geo-political development in recent years, the question of sacrifice has come to the fore in the contemporary philosophical discussion. Does sacrifice merely sharpen conflicts between cultures, or should it be seen as an inevitable part of their foundation? This article addresses the question from the perspective of the biblical view of sacrifice, expressed paradigmat- ically in

What can box jellyfish tell us about early eye evolution?

The eyes of visually prominent animals such as vertebrates, cephalopods, and arthropods generally subserve a multitude of visual tasks. Naturally, early stages in the evolution of these complex visual organs must have been simpler, and subserved a smaller number of visual tasks. Hence, eye evolution is driven by a consecutive accumulation of visual tasks. Each task adds to the requirements on eye

Patients' experiences of illness, operation and outcome with reference to gastro-oesophageal reflux disease.

Background. Describing the illness-story from a patient perspective could increase understanding of living with a chronic disease for health professionals and others, facilitate decision-making about treatment and enhance information about the outcome from a patient perspective. Aim. To illuminate patients' illness experiences of having a gastro-oesophageal reflux disease (GORD), going through sur

Utilisation of physician services in the 50+population: the relative importance of individual versus institutional factors in 10 European countries

We analysed the relative importance of individual versus institutional factors in explaining variations in the utilisation of physician services among the 50+ in ten European countries. The importance of the latter was investigated, distinguishing between organisational (explicit) and cultural (implicit) institutional factors, by analysing the influence of supply side factors, such as physician de

Climate effects on offspring sex ratio in a viviparous lizard

Understanding individual and population responses to climate change is emerging as an important challenge. Because many phenotypic traits are sensitive to environmental conditions, directional climate change could significantly alter trait distribution within populations and may generate an evolutionary response. In species with environment-dependent sex determination, climate change may lead to

A Contextual Integration of Individual and Organizational Learning Perspectives as Part of IS Analysis

The Strategic Systemic Thinking (SST) framework is presented as a stepping stone towards enabling the refocusing of organizational analysis in Information Systems (IS). The paper introduces some of the fundamental assumptions regarding the objectives of the SST framework; such as sense making as learning processes build upon communicative actions. The main concepts of the SST framework are present

Probing Molecular Interactions within Class II MHC A(q)/Glycopeptide/T-Cell Receptor Complexes Associated with Collagen-Induced Arthritis.

T cells obtained in a mouse model for rheumatoid arthritis are activated by a glycopeptide fragment from rat type II collagen (CII) bound to the class II major histocompatibility complex A(q) molecule. We report a comparative model of A(q) in complex with the glycopeptide CII260-267. This model was used in a structure-based design approach where the amide bond between Ala(261) and Gly(262) in the

Cross-bridge kinetics and shortening in smooth muscle

Stiffness measurements were performed on smooth muscle preparations from guinea-pig taenia coli to obtain information on the number of attached cross bridges under varying contractile conditions. The normalized stiffness of the cross-bridge system in smooth muscle may be of a magnitude similar to that assumed in skeletal muscle. Transition from isometric contraction to unloaded shortening was asso

The X4 phenotype of HIV type 1 evolves from R5 in two children of mothers, carrying X4, and is not linked to transmission

Previously, we found that emergence of the X4 viral phenotype in HIV-1-infected children was related to the presence of X4 in their mothers (C. H. Casper et al., J Infect Dis 2002; 186: 914-921). Here, we investigated the origin of the X4 phenotype in the child, analyzing two mother-child pairs (Ma-Ca, Mb-Cb) where the mothers carried X4 and their children developed X4 after an initial presence of

Application of the PROFILE model to estimate potassium release from mineral weathering in Northern European agricultural soils

Negative potassium (K) balances have been reported from grass-dominated organic systems in several European countries, and in these systems delivery of K from soil primary minerals by weathering is probably crucial to sustained productivity. Mass balances and K budgets have been made at eight grass-dominated experimental agricultural systems, one each in Scotland and Sweden and six in Norway. Wher