Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients.

The effects of composition changes and heat treatment on the microstructure and mechanical properties of high-chromium white cast irons were studied in order to characterize possible improvements in product performance and machinability. Materials characterization was performed using nanoindentation, SEM, and EDS techniques. Present results show that changes in carbon and silicon contents as well

Anti-neutrophil cytoplasmic antibodies (ANCAs) have a pathogenic role in ANCA-associated vasculitis. The origin of ANCAs and anti-glomerular basement membrane (GBM) antibodies, however, is unknown. In this study, we determined whether natural autoantibodies against myeloperoxidase (MPO), proteinase 3 (PR3), and GBM were present in each of 10 healthy Chinese and Swedish individuals, negative for al

Popular Abstract in Swedish Sammanfattning Varför ungdomar använder tobak är en stor och komplex fråga. Det finns faktorer på samhälls-, grupp- och individnivå som påverkar unga. Omgiv-ningens normer och attityder liksom föräldrars och kompisars tobaksvanor har betydelse och påverkar ungdomar att börja använda tobak eller att avstå. För att motverka tobaksbruk krävs en kombination av åtgärder på Why adolescents are using tobacco is a large and complex issue. There are factors on society, group and individual levels that affect the youngsters. The norms and attitudes in their surrounding, as well as the tobacco habits of parents and friends, are important when it comes to affecting adolescents to start using tobacco or abstain from it. Counteracting the use of tobacco requires a combinatio

In a previous paper, an approximate model for the contact between a rubber covered roller and a rigid roller was developed as analytical functional relationships connecting geometric parameters and material properties of the rubber to nip properties such as maximum contact pressure, etc. in a two-dimensional relationship. The results from that development are used in this work, with the objective

OBJECTIVE - Impaired muscular mitochondrial function is related to common insulin resistance in type 2 diabetes. Mitochondrial diseases frequently lead to diabetes, which is mostly attributed to defective beta-cell mitochondria and secretion. RESEARCH DESIGN AND METHODS - We assessed muscular mitochondrial function and lipid deposition in liver (hepatocellular lipids [HCLs]) and muscle (intramyoce

This paper explores strategic change communication, framed by the idea that managers can be viewed as rhetoricians. The purpose of this paper is to present and discuss senior managers’ subjective experiences of rhetorical aspects of change management. The paper draws on a case study from ABB Sweden (a power and automation technology company). In-depth interviews with senior managers, with vast ex

Introduction to special issue on Business Ethics, in the Journal of Business Anthropology. Today, business ethics can be found everywhere. But how can we define it intellectually? What does this concept include? How can we define it in explicitly anthropological terms? For the manager as well as the anthropologist, business ethics – in thoughts or in actions – involves dealing with opposing notion

Rab7 is a member of small GTP-binding protein family involved in intracellular vesicle trafficking from late endosome to vacuole, some of them are found to be responsive by different environmental stresses. Here we report the isolation of a Rab7 (RabG3b) cDNA from peanut (Arachis hypogaea). Overexpression of the open reading frame (ORF) of Rab7 cDNA encoding 205 amino acids in E. coli conferred th

Background. Sporadic cases of abdominal pain and dysmotility has been described after treatment with gonadotropin-releasing hormone (GnRH) analogs. The aim of the present study was to scrutinize for patients with severe gastrointestinal complaints after treatment with GnRH analogs, to describe the expression of antibodies against progonadoliberin-2, GnRH1, GnRH receptor (GnRHR), luteinizing hormon

Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers. Methods: IRS1

A Mathematica package for color summed calculations in QCD (SU(N-c)) is presented. Color contractions of any color amplitude appearing in QCD may be performed, and the package uses a syntax which is very similar to how color structure is written on paper. It also supports the definition of color vectors and bases, and special functions such as scalar products are defined for such color tensors.

Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial. Methods: 373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and sel

In Russia, as in some other countries around the world, we are currently witnessing a wave of politically sanctioned homophobia, most concretely manifested in the 2013 law against “homosexual propaganda”. By examining Russian mainstream media reporting, this article aims to reconstruct a dominant narrative on homosexuality and LGBT rights. It is found that this narrative revolves around three trop

We consider the operator -d(2)/dr(2) - V in L-2(R+) with Dirichlet boundary condition at the origin. For the moments of its negative eigenvalues we prove the bound [GRAPHICS] for any alpha is an element of [0, 1) and gamma >= (1 - alpha)/2. This includes a Lieb-Thirring inequality in the critical endpoint case.

Mathematical modelling has proven to be very useful in process design, operation and optimisation. A recent trend in WWTP modelling is to include the different subunits in so-called plant-wide models rather than focusing on parts of the entire process. One example of a typical plant-wide model is the coupling of an upstream activated sludge plant (including primary settler, and secondary clarifier

Signal crayfish (Pacifastacus leniusculus) have become increasingly widespread in rivers in Great Britain since their introduction in the late 1970s, causing extensive losses of indigenous white-clawed crayfish and negative impacts on communities of aquatic plants, invertebrates and benthic fish. Angling interests are increasingly concerned about possible impacts of signal crayfish on brown trout,

Kuannersuit Glacier, a valley glacier on Disko Island in west Greenland, experienced a major surge from 1995 to 1998 where the glacier advanced 10.5 km and produced a similar to 65 m thick stacked sequence of debris-rich basal ice and meteoric glacier ice. The aim of this study is to describe the tectonic evolution of large englacial thrusts and the processes of basal ice formation using a multipr