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Alzheimer’s disease (AD) continues to pose a major global health challenge, with incidence rising sharply and current therapies offering only symptomatic relief. This study builds on prior work into six structurally diverse multi-target compounds (1–6) designed to modulate key pathological processes in AD. We have now combined experimental and computational approaches to determine a set of pharmac

How does coalition participation influence party membership? We argue that parties that take part in coalition governments are likely to experience less favorable party membership developments than parties governing alone because of the compromises they have to agree on in multi-party cabinets. This should be particularly likely for parties in ideologically diverse coalition governments since part

Control of crystallographic texture is key to improving the properties of piezoelectric ceramics, but it has so far mainly been realized in the form of fiber textures perpendicular to the dominant surface of simple 2.5D structures. This work demonstrates how grains in piezoelectric ceramics can be aligned in complex patterns and shapes via material extrusion-based additive manufacturing, specifica

Precise mapping of structural heterogeneity at the sub-10 nm scale is pivotal for rational nanoparticle design, yet conventional analytical workflows remain inadequate. Here we integrate dilution-controlled asymmetric flow field-flow fractionation (AF4) with small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) to interrogate ellipsoidal solid–liquid lipid nanoparticles (LN

Osteoarthritis (OA) is an age-related disease of the joint in which the tissues degenerate and the function of the joint is disrupted. Key load-bearing tissues that break down as part of knee osteoarthritis include the articular cartilage and the meniscus. These tissues are complex cartilaginous tissues, consisting of around 70% water confined in a network of collagens and proteoglycans. During OA

This paper investigates the role of sound and listening in establishing newsensory connections with the environment. Climate change is affecting the wayour environment sounds and we need to expand our sense of listening to tunein to those new registers. Through the development of a digital prototype forspeculative sound co-creation, this study explores ways to engage with ourchanging environment b

In this workshop, we explore the question: How can we use our senses toknow trees and foster ecological empathy through interdisciplinary methodsacross landscape design, sound art, and dance/movement? We inviteparticipants to develop sensory responses to real or imaginary trees asimpetus for sonic kinesthetic expression. The workshop will encourageinteraction with trees to reveal the aliveness and

Background Early-onset depression contributes significantly to long-term disability and suicide, making high-quality healthcare for young people with depression a critical concern. Medical record review (MRR) is widely used to assess healthcare quality. However, its application to depression care for children and adolescents appears underexplored, with no consensus on conceptualising or measuring

The Quercetum Chorus Workshop introduced students in the Cal Poly Pomona Interdisciplinary Paris Study Abroad Program (CPP IPSAP) to methods of deepening human-tree relations through sound, drawing and movement. Students applied a multi-sensory approach to knowing trees by attuning to their frequencies, textures, shapes, and movements. They were invited to reimagine trees as more-than-human bodies

Background: Over time, family structures have grown more complex, diversifying adult relationships. While research has compared marital, cohabiting and living apart together relationships based on quality and health, less is known about their sexual dynamics. Theoretical frameworks suggest that co-resident relationships may integrate sexuality differently from living apart together unions, where p

Cet article expose la perspective d’un field recording basé sur la notion de fictions soniques pour examiner une réalité de l’environnement de manière protéiforme et nous conduit ici à envisager, à travers l’expérience du son, à quel point celle-ci nous permet d’agir sur les espaces et leurs représentations. La fiction sonique désigne une capacité à façonner des mondes fantastiques et virtuels par

Recent observations from the James Webb Space Telescope have revealed unexpectedly luminous galaxies, exhibiting stellar masses and luminosities significantly higher than predicted by theoretical models at Cosmic Dawn. In this study, we present a suite of cosmological zoomed-in simulations targeting high-redshift (z ≥ 10) galaxies with dark matter halo masses in the range 1010-1011M⊙ at z = 10, us

We propose a method for estimating the 3D position of a target point, given multiple measurements of it, using mm-wave radar data. Given azimuth headings and range estimates from posed radar positions, we find the 3D position, using an approximate, but geometrically and statistically meaningful cost. The 3D position is found in an optimal way, using this approximate cost. By deriving the Lagrangia

Non-invasive MRI is widely used to assess and monitor ischemic stroke, yet conventional approaches often lack sensitivity to subtle microstructural changes and struggle to evaluate tissue viability across lesion, penumbra, and distal regions. In this study, frequency dependent diffusion tensor distribution imaging (ωDTD) was combined with clustering of diffusion tensor distributions D(ω) and multi

Parkinsons sjukdom förknippas ofta med rörelsesymtom, som skakningar, stelhet och långsammare rörelser. Sjukdomen kan dock också påverka talet. Rösten kan bli svagare, mindre varierad eller mindre stabil, och uttalet kan bli svårare att kontrollera. Eftersom tal är enkelt att spela in och inte kräver några invasiva undersökningar är det intressant att undersöka om tal kan användas som en källa tilSpeech has become an increasingly important source of non-invasive information for Parkinson's disease detection, but much existing work still relies on sustained vowels. This thesis investigates whether carefully represented continuous speech can provide added predictive value over a strong sustained-vowel benchmark. Using the NeuroVoz corpus, sustained-vowel recordings were first used to est

Past and present measurements of radionuclide activity concentrations in the seaweed species Fucus spp. on the Swedish west coast have shown significant temporal variation. The current understanding is that marine discharges originating from remote nuclear facilities contribute to the observed activity levels. Initial statistical exploration has been done, but no detailed modelling has been perfor