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Cross-reactions between engineered xylose and galactose pathways in recombinant Saccharomyces cerevisiae

BACKGROUND: Overexpression of the PGM2 gene encoding phosphoglucomutase (Pgm2p) has been shown to improve galactose utilization both under aerobic and under anaerobic conditions. Similarly, xylose utilization has been improved by overexpression of genes encoding xylulokinase (XK), enzymes from the non-oxidative pentose phosphate pathway (non-ox PPP) and deletion of the endogenous aldose reductase

Forskning om diakoni - en litteraturöversikt

En inventering och presentation av fr.a. svensk forskning om diakoni och kyrkors sociala verksamheter. Först redovisas historisk forskning om fattigvård och diakoni. Därefter samhälls- och flervetenskaplig forskning, samt forskning om diakonatet och systematisk-teologisk forsknning

Cardiovascular disease and adrenergic dysfunction in mild primary hyperparathyroidism

Popular Abstract in Swedish Primär hyperparathyroidism (PHPT) är en sjukdom som beror på abnormt ökad produktion av parathormon (PTH) i en eller flera av de vanligen fyra bisköldkörtlarna. PTH har som uppgift är att reglera nivån av kalcium i blodet (i dagligt tal ofta kallad ”blodkalken”) inom snäva gränser. Den förhöjda halten av PTH och den åtföljande stegringen av kalciumnivån i blodet vid PHPPrimary hyperparathyroidism (PHPT) is associated with cardiovascular morbidity and premature death, but the underlying mechanisms are incompletely understood. The aim of this thesis was to investigate cardiovascular parameters and adrenergic function in mild PHPT compared to healthy controls subjects before and after curative parathyroidectomy (PTX). Forty-nine patients with mild PHPT (serum calci

Power Transformer Immune to Geomagnetically Induced Currents

Geomagnetically induced currents (GICs) flow mainly through power lines, earthed transformers and earth itself. The near DC currents may cause half-cycle saturation of transformers, possibly causing relay misoperation, increased reactive power demand and damage to transformers. This paper describes a patented idea to make a transformer immune to GIC using compensation windings in each phase. A com

Stress analysis of highly constrained copper strips with through crack shaped voids using molecular dynamics

A small rectangular strip of fcc Cu, containing a through crack on the nanoscale and subjected to loading under displacement control, is simulated using molecular dynamics (MD). The geometry is highly constrained and chosen to mimic that of a thin strip between two stiff layers. The Lennard-Jones pair potential is used for the inter-atomic forces. The centrally placed crack shaped void is created

To the rhythm of shopping - on synchronisation in urban landscapes of consumption

This article deals with the impact of retail rhythms on urban life and the urban landscape, with a special focus on tendencies toward synchronisation. The article is divided into three sections. First, the history of synchronisations in public space is traced, and it is argued that the retail business has become an increasingly important actor in the production of urban temporal landscapes. Second

Dilepton mass spectra in p plus p collisions at root s=200 GeV

PHENIX has measured the electron-positron pair mass spectrum from 0 to 8 GeV/c(2) in p + p collisions at root s = 200 GeV. The contributions from light meson decays to e(+)e(-) pairs have been determined based on measurements of hadron production cross sections by PHENIX. Within the systematic uncertainty of similar to 20% they account for all e(+)e(-) pairs in the mass region below similar to 1 G

Regional Management Units for Marine Turtles: A Novel Framework for Prioritizing Conservation and Research across Multiple Scales

Background: Resolving threats to widely distributed marine megafauna requires definition of the geographic distributions of both the threats as well as the population unit(s) of interest. In turn, because individual threats can operate on varying spatial scales, their impacts can affect different segments of a population of the same species. Therefore, integration of multiple tools and techniques

Validity and reliability of the Cold Discomfort Scale: a subjective judgement scale for the assessment of patient thermal state in a cold environment

Complementary measures for the assessment of patient thermoregulatory state, such as subjective judgement scales, might be of considerable importance in field rescue scenarios where objective measures such as body core temperature, skin temperature, and oxygen consumption are difficult to obtain. The objective of this study was to evaluate, in healthy subjects, the reliability of the Cold Discomfo

The other side of enjoyment: short-circuiting marketing and creativity in the experience economy

The notion of experience economy asserts that staging the most mundane consumption practise as individualized entertainment adds value to the producer and consumer alike (Pine and Gilmore, 1999). This article questions this assumption of mere added value. Probing into an interplay between a marketing fantasy and a customer movement passionately engaging with its promise, it draws attention to a st

Size matters-sometimes. The [CuxIy]((y-x)-)(NR4)(+)((y-x)) systems

A systematic study of compounds formed by solvolysis of Cu in a solution of iodine in acetol in the presence of homotetraalkylammonium iodide has resulted in five new compounds: catena tetrakis (tetramethylammonium) bis(mu(3)-iodo)-mu(2)-iodo-tri-copper(I), hexakis(tetrabutylammonium) tetrakis(mu(3)-iodo)-tris(mu(2)-iodo)-di-iodo-hexa-copper(I) pentakis(mu(3)-iodo)-tetrakis(mu(2)-iodo)-di-iodo-hep

Norrmän i tysk tjänst

Recension av Tarje Emberland & Matthew Kott, Himmers Norge – Nordmenn i det storgermanske prosjekt.

HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes.

Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections. We hypothesized that the local HMGB1 response is excessive in severe soft tissue infections (STIs), which are characterized by necrosis and hyperinflammation. To explore this, tissue biopsies were collected fro

Decoupled Sampling for Graphics Pipelines

We propose a generalized approach to decoupling shading from visibility sampling in graphics pipelines, which we call decoupled sampling. Decoupled sampling enables stochastic supersampling of motion and defocus blur at reduced shading cost, as well as controllable or adaptive shading rates which trade off shading quality for performance. It can be thought of as a generalization of multisample ant

Age-related changes of phasic heart rate responses to affective pictures.

This study examined age differences in phasic heart rate in response to neutral, negative and positive pictures. Heart rate changes and subjective ratings were analyzed in 22 middle-aged (40-55 years) and 30 older (56-78 years) participants. The effects of valence on the HR pattern across time were similar to that obtained by Bradley and co-workers. Conversely to previous studies, we did not repor