Rituximab is a pioneering anti-CD20 monoclonal antibody that became the first-line drug used in immunotherapy of B-cell malignancies over the last twenty years. Rituximab activates the complement system in vitro, but there is an ongoing debate on the exact role of this effector mechanism in therapeutic effect. Results of both in vitro and in vivo studies are model-dependent and preclude clear clin

The COVID-19 pandemic has raised awareness of the urgent need to improve the design of health systems, as well as the practical implementation of new strategies and technical solutions to better prepare for future pandemics. These preparations must also consider harms secondary to the pandemic, including the resulting effects on antimicrobial resistance (AMR). While drug-resistant infections pose

CALIFA is the high efficiency and energy resolution calorimeter for the R3B experiment at FAIR, intended for detecting high energy charged particles and γ-rays in inverse kinematics direct reactions. It surrounds the reaction target in a segmented configuration of Barrel and Forward End-Cap pieces. The CALIFA Barrel consists of 1952 detection units made of CsI(Tl) long-shaped scintillator crystals

We measured absolute cross sections for neutron transfer channels populated in the Rb94+Pb208 binary reaction. Cross sections have been extracted identifying directly the lead isotopes with the high efficiency MINIBALL γ-ray array coupled to a particle detector combined with a radioactive Rb94 beam delivered at Elab=6.2 MeV/nucleon by the HIE-ISOLDE facility. We observed sizable cross sections in

We present direct photon-hadron correlations in 200 GeV/A Au+Au, d+Au, and p+p collisions, for direct photon pT from 5-12 GeV/c, collected by the PHENIX Collaboration in the years from 2006 to 2011. We observe no significant modification of jet fragmentation in d+Au collisions, indicating that cold nuclear matter effects are small or absent. Hadrons carrying a large fraction of the quark's momentu

The measurements of the (anti)deuteron elliptic flow (v2) and the first measurements of triangular flow (v3) in Pb-Pb collisions at a center-of-mass energy per nucleon-nucleon collision sNN = 5.02 TeV are presented. A mass ordering at low transverse momentum (pT) is observed when comparing these measurements with those of other identified hadrons, as expected from relativistic hydrodynamics. The m

Hanbury Brown-Twiss interferometry (HBT) provides crucial insights into both the space-time structure and the momentum-space evolution of ultrarelativistic nuclear collisions at freeze-out. In particular, the dependence of the HBT radii on the transverse pair momentum KT and the system charged multiplicity dNch/dη may reflect the mechanisms driving collective behavior in small systems. This paper

This paper discusses the problem of testing the performance of the adaptation layer in a self-adaptive system. The problem is notoriously hard, due to the high degree of uncertainty and variability inherent in an adaptive software application. In particular, providing any type of formal guarantee for this problem is extremely difficult. In this paper we propose the use of a rigorous probabilistic

Background: Breast compression in mammography is important but is a source of discomfort and has been linked to screening non-attendance. Reducing compression has little effect on breast thickness, and likely little effect on image quality, due to force being absorbed in the stiff juxta thoracic area instead of in the central breast. Purpose: To investigate whether a flexible compression plate can

Background: Alzheimer's disease co-pathology is common in dementia with Lewy bodies and Parkinson's disease with dementia (Lewy body disease) and can reliably be detected with positron emission tomography (PET) or cerebrospinal fluid (CSF) biomarkers. Recently developed blood biomarkers are more accessible and less expensive alternatives. Objective: To investigate if plasma phospho-tau217 and phos

Children's early engagement in design of outdoor spaces can form the basis of later attitudes and responsible action for sustainability. The present study is part of a participatory action research project in an urban multi-ethnic preschool in Sweden, involving children, parents, preschool staff and management with a focus on improving the preschool playground. The methodology involved children ta

Developing a novel therapeutic product for the treatment of type 2 diabetes (T2D) is a long, resource-intensive process. Novel biomarkers could potentially aid clinical trial design by shortening clinical trials or enabling better prediction of at-risk populations and/or disease progression. Novel clinical trial designs could lead to reduced costs of development and less burden to patients, due to

Removing bus stops is often a prerequisite for introducing faster, more reliable, and more frequent rail or coach services in rural areas. Despite the potentially higher quality of service through trains or coaches, however, the bus-stop removals often become stumbling blocks. It is sometimes feared that the alterations to the public transport network will pose a threat to the possibilities of liv

Det antika Athen hade sin första blomstringstid under 400- och 300-talen f.Kr. Det hade då en ledande ställning i den grekiska världen, och från den tiden härstammar mycket av det som väckt senare tiders beundran – klassisk skulptur, arkitektoniska mästerverk som Parthenon, dramerna som fortfarande spelas på våra teatrar, Sokrates, Platons och Aristoteles landvinningar inom tankens värld. Detta är

This paper proposes a critical assessment of the jurisprudence of the Inter-American Court of Human Rights (IACRTHR) regarding the systemic integration of the provisions enshrined in the American convention on human rights (ACHR), under the light of the developments of the corpus juris of international human rights law. By incorporating the evolution in the interpretation of human rights law into

Accurately manufactured gears require a reliable, holistic, and fast inspection method. Standardised geometrical parameters enable a consistent and regulated inspection of gears; however, current inspection methods include only a limited set of measurements for gears at specific locations. Therefore, a method to obtain holistic three-dimensional (3D) measurements with an optical inspection was tho

Information systems are key enablers for the integration and reliable management of the product development process. Information systems are the backbone that connects various sub-processes and enables flexible product customization. Fast, robust, and cost-efficient product adaptation is especially important in one-of-a-kind production. This paper presents a transformation of the product developme

The smart factories that are already beginning to appear employ a completely new approach to product creation. Smart products are uniquely identifiable, know their current status and alternative routes to achieving their target state. The embedded manufacturing systems are vertically networked with business processes and horizontally connected to disperse value networks that can be managed in real