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Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein

Dimethyl sulfoxide (DMSO) is a highly utilized small molecule that serves many purposes in scientific research. DMSO offers unique polar, aprotic and amphiphilic features, which makes it an ideal solvent for a wide variety of both polar and nonpolar molecules. Furthermore, DMSO is often used as a cryoprotectant in cell-based research. However, recent reports suggest that DMSO, even at low concentr

Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits

The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the av

Evaluating an internet-delivered fear conditioning and extinction protocol using response times and affective ratings

Pavlovian fear conditioning is widely used to study mechanisms of fear learning, but high-throughput studies are hampered by the labor-intensive nature of examining participants in the lab. To circumvent this bottle-neck, fear conditioning tasks have been developed for remote delivery. Previous studies have examined remotely delivered fear conditioning protocols using expectancy and affective rati

Dual antithrombotic treatment in chronic coronary syndrome : European Society of Cardiology criteria vs. CHADS-P2A2RC score

AIMS: According to the 2019 European Society of Cardiology (ESC) guidelines on chronic coronary syndromes (CCS), adding a P2Y12 inhibitor or rivaroxaban to aspirin should be considered in high-risk patients. We estimated the proportion of patients eligible for treatment with the ESC criteria and examined if a recently validated risk score (CHADS-P2A2RC) could improve risk prediction. METHODS AND R

Experimental determination of k Qfactors for two types of ionization chambers in scanned proton beams

Objective. Experimental determination of beam quality k Q factors for two types of Farmer ionization chambers, NE2571 and IBA FC65-G, in a scanned proton beam for three nominal energies (140 MeV, 180 MeV and 220 MeV) based on water calorimetry. Approach. Beam quality correction factors were determined comparing the results obtained with water calorimetry and ionometry. Water calorimetry was perfor

Oxidation of 5-hydroxymethylfurfural with a novel aryl alcohol oxidase from Mycobacterium sp. MS1601

Bio-based 5-hydroxymethylfurfural (HMF) serves as an important platform for several chemicals, among which 2,5-furan dicarboxylic acid (FDCA) has attracted considerable interest as a monomer for the production of polyethylene furanoate (PEF), a potential alternative for fossil-based polyethylene terephthalate (PET). This study is based on the HMF oxidizing activity shown by Mycobacterium sp. MS 16

Allocation of ecological water rights considering ecological networks in arid watersheds : A framework and case study of Tarim River basin

A robust water supply system is significant to the local ecosystem of riparian vegetation in the arid basin. Considering the elasticity and relative importance of ecological water use in different regions of the basin, this study defines the ecological water rights on a multi-year scale, divides the priority of those rights based on the ecological network, and proposes a rights allocation method.

Den förste hemiten

Redogörelse för de tidiga lundensiska (och i någon mån uppsaliensiska) studenthemmens tillkomst kopplad till en biografisk skiss över den förste "hemiten" (boende på Thomanders studenthem), Emil Sommarin, respektive ett resonemang huruvida denne kan ses som en "typisk" hemit.

Microscopic treatment of instantaneous spectral diffusion and its effect on quantum gate fidelities in rare-earth-ion-doped crystals

The effect of instantaneous spectral diffusion (ISD) on gate operations in rare-earth-ion-doped crystals is an important question to answer for the future of rare-earth quantum computing. Here we present a microscopic modeling that highlights the stochastic nature of the phenomenon and use it to investigate ISD errors on single-qubit gate operations. Furthermore, we present a method to estimate th

High-connectivity quantum processor nodes using single-ion qubits in rare-earth-ion-doped crystals

We present two protocols for constructing quantum processor nodes in randomly doped rare-earth-ion crystals and analyze their properties. By varying the doping concentration and the accessible laser tunability, the processor nodes can contain anywhere from only a few tens to almost 1000 qubits. Furthermore, the average number of qubits each qubit can interact with, denoted by the connectivity, can

Genomic privacy? : Direct-to-consumer genetic testing companies and the processing of sensitive personal data

This paper explores the processing of sensitive personal data for genealogical purposes by studying how the privacy policies of three direct-to-consumer genetic testing companies relate to the general Data Protection Regulation (GDPR). The methodological approach is content analysis. The privacy policies are analysed in relation to the three core principles of 1) adherence to GDPR; 2) transparent

When Organizational Crises Meet Nationalism: Crisis Communication of Multinational Corporations in the Chinese Context

The purpose of this study is to explore how nationalism shapes the public perception of multinational corporations’ crises on Chinese social media. Using qualitative content analysis, this study examines 1,000 public comments from the top 10 hashtag posts and explores the interaction between nationalist expression (i.e., content and sentiment of nationalism) and the public’s perception of the Unit

Att göra utredningar inom offentlig sektor

Även om spännvidden är stor vad gäller fackområde, beslutssituation och omfattning har utredningarna det gemensamt att de behöver vägledas av rekommendationer för hur utredningsarbete bedrivs och bedöms på bästa sätt. Att göra utredningar inom offentlig sektor strävar efter att presentera olika metodfrågor på ett enkelt sätt. Boken förklarar också logiken bakom olika metodkrav, till exempel kravet

Generalizing solutions across functionally similar problems correlates with world knowledge and working memory in 2.5- to 4.5-year-olds

Analogical transfer, denoting the ability to use an action that solved a given problem in order to successfully handle a seemingly different but functionally similar problem, requires well- developed self-regulation, as it draws on previous knowledge and demands selecting and shift- ing between relevant features while ignoring irrelevant ones. Thus, analogical transfer involves executive functions

Vägen till validering

Projektet bygger på ett samarbete med regionens folkhögskolor och Folkuniversitetet när det gäller behörighetsgivande utbildning. Det är med andra ord viktigt att göra en kartläggning av hur olika universitetsförberedande utbildningar arbetar för att säkerställa behörighet och hur detta skall kunna bli en integrerad del av arbetet med breddad rekrytering på Lunds universitet.

Tornet vid havet - ledtrådar till historien bakom Hagbards källare

Strax sydöst om Ronneby i anslutning till Angelåns utlopp i Angelskogsviken, öster om Ronnebyhamn , ligger en anläggning som i folkmun kallas ”Hagbards källare”. Det utgör resterna av ett medeltida torn. Artikeln berättar om de preliminära resultaten av en arkeologisk undersökning 2021.