Hematopoietic stem cells (HSCs) are typically characterized by transplantation into irradiated hosts in a highly perturbed microenvironment. Here, we show that selective and temporally controlled depletion of resident HSCs through genetic deletion of Gata2 constitutes efficient recipient conditioning for transplantation without irradiation. Strikingly, we achieved robust engraftment of donor HSCs

High salt concentration has been shown to induce increased electrochemical stability in organic solvent-based electrolytes. Accompanying the change in bulk properties is a structural ordering on mesoscopic length scales and changes in the ion transport mechanism have also been suggested. Here we investigate the local structure and dynamics in highly concentrated acetonitrile electrolytes as a func

Around the world Covid-19 has been battled by trying to get the public to change how they behave: to reduce social interactions and the risks associated with them. In order to change behaviour it is not enough, however, to simply tell people what to do. Successful interventions also need to communicate how to do it. Here I dis-cuss the difference between nudges (influencing behaviour) and boosts (

In the early Holocene, Mesolithic hunter-gatherer communities inhabiting the Cis-Baikal region of Eastern Siberia were participating in a series of important cultural changes. These included the establishment of large cemeteries in the Angara Valley and on the Southwest shores of Lake Baikal, culminating in the formation of the distinctive Early Neolithic Kitoi cultural pattern ca. 7560 cal. BP. A

Although sled dogs are one of the most specialized groups of dogs, their origin and evolution has received much less attention than many other dog groups. We applied a genomic approach to investigate their spatiotemporal emergence by sequencing the genomes of 10 modern Greenland sled dogs, an ~9500-year-old Siberian dog associated with archaeological evidence for sled technology, and an ~33,000-ye

Pottery technology, originating in Northeast Asia, appeared in Alaska some 2800 years ago. It spread swiftly along Alaska's coastline but was not adopted on Kodiak Island until around 500 cal BP, as part of the Koniag tradition. While in the southeast pottery was used extensively, people on the northern half of the island did not adopt the technology. What drove these patterns of adoption and non-

Hamanaka 2 is a multi-phase coastal site in Rebun Island with a ~ 3000-year occupation sequence extending from the final-stage Jōmon and Okhotsk to the Ainu Culture period (1050 BCE-1850 CE). To examine long-term trends in food processing at the site, we collected 66 ceramic sherds across six distinct cultural layers from the Final Jōmon to the Late Okhotsk period for lipid residue analysis. Given

This abstract is based on a pilot study from an ongoing project focusing the implementation of a digital platform offering support for both the patient- and workflow at a primary healthcare center in Western Sweden. The overarching aim of the project is to follow the introduction and adaptation (normalization) of the platform in primary healthcare centers to study how digital support of the patien

Modern Arctic Indigenous peoples face many interconnected pressures, not the least of which is anthropogenic climate change, which is emerging as one of the most dramatic drivers of social and economic change in recent memory. In this paper, we investigate whether or not insights into premodern strategies for coping with climate change—and especially the “deeper histories” of traditional ways-of-k

Special Issue Editorial

We briefly review the various machine learning methods and discuss how they can be used in efficient identification and analysis of spectroscopic binary stars. They can be treated as complementary to conventional methods, and we argue that some amount of human oversight is always needed and in fact highly beneficial when employing machine learning. We propose that a general dimensionality reductio

Purpose: The purpose of this study is to discuss the concept of information in relation to temporality within the context of climate change communication. Furthermore, the paper aims to highlight the empirical richness of information as a concept by analysing its use in context. Design/methodology/approach: The discussion is based on 14 semi-structured interviews with initiators and collaborators

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes coding for ribosomal proteins. Among these genes, the ribosomal protein S19 (RPS19) gene is the most frequently mutated. Previously, a mouse model deficient in RPS19 was developed by our laboratory, which recapitulates the hematopoietic disease phenotype by manifesting pathologic f

Most parts of the Circumpolar Arctic have only discontinuous evidence for long-term human settlement. In contrast, Northern Norway has an unbroken archaeological record that extends back to the early Holocene. Numerous high-resolution archaeological and palaeoenvironmental records have been generated by commercial excavations and surveys, offering archaeologists unique opportunities to investigate

During the last glacial–interglacial cycle, Arctic biotas experienced substantial climatic changes, yet the nature, extent and rate of their responses are not fully understood1–8. Here we report a large-scale environmental DNA metagenomic study of ancient plant and mammal communities, analysing 535 permafrost and lake sediment samples from across the Arctic spanning the past 50,000 years. Furtherm

In 2015, FIGO revised the 1987 intrapartum cardiotocography (CTG) classification (FIGO1987). A less radical FIGO2015 version was introduced in Sweden 2017 (SWE2017). Now, post hoc simulation studies show that FIGO2015 and SWE2017 are less reliable than (a modified) FIGO1987. FIGO2015 shows significantly better interobserver agreement for normal CTG traces than FIGO1987, but significantly worse for

Lipids preserved within the walls of ancient pottery vessels are routinely analysed to reveal their original contents. The provenience of aquatic lipids in pottery is generally connected to vessel function (e.g., for cooking or storing fish, shellfish and aquatic mammals). However, ethnographic reports from early historic Alaska mention the use of aquatic oils for waterproofing low-fired pottery.

This work presents an on-chip memory subsystem envisioned for real-time applications performing Oriented FAST and Rotated Brief (ORB) feature extraction for Simultaneous Localization and Mapping (SLAM) systems. For autonomous navigation of battery-powered devices, feature-based SLAM is a computationally frugal alternative to direct methods. This paper thoroughly analyses ORB multiple memory access