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The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but the underlying pathophysiology remains unclear. We studied the effect of this variant on hepatic metabolism in homozygous carriers and non-carriers under multiple physiological conditions with state-of-the-art stable isotope techniques. After an overnight fast, carriers had higher plasma β-hydroxyb

Responding to perceived threats is energetically expensive and can require animals to curtail somatic repair, immunity, and even reproduction to balance energy ledgers. In birds and mammals, energetic demands of thermoregulation are often immense, yet whether homeostatic body temperatures are also compromised to aid the stress response is not known. Using data sourced from over 60 years of literat

Synchrotron radiation (SR) from bending magnets, wigglers, and undulators is now extensively produced for users at storage ring based light sources, with unique properties in terms of average brightness and stability. We present a profound study of bending magnet SR intensity distribution in the image plane of a focusing optical system. Measurements of this intensity distribution at the MAX-IV low

This study regards a Child Play-and-Learn Area (CPLA) in a library as a third place and investigates its relationships with visitors through the concept of place attachment. To understand the influence of the CPLA, the study examined the relationships among visitors' place attachment, servicescape and behavioural intentions involving place scales. A survey was conducted in a CPLA in Christchurch,

Introduction: We assessed best available data on access and delivery of acute stroke unit (SU) care, intravenous thrombolysis (IVT) and endovascular treatment (EVT) in the European region in 2019 and 2020. Patients and methods: We compared national data per number of inhabitants and per 100 annual incident first-ever ischaemic strokes (AIIS) in 46 countries. Population estimates and ischaemic stro

Purpose: To illustrate the technique of antegrade in situ laser fenestration (ISLF) on a predesign custom-manufactured stent-graft with single reinforced fenestration for use in emergency endovascular repair of complex abdominal aortic aneurysms (AAAs). Technique: A short custom-made device (CMD) fenestrated graft was predesigned with a single preloaded 8 mm strut-free fenestration at 12 o’clock p

Today's Carrier-Envelope Phase (CEP) stabilizations of mode-locked oscillators widely used in attosecond science and frequency metrology rely on octave spanning frequency combs and the detection of beating between the blue end and the frequency doubled red end of the same spectrum. This technique was established by the seminal works of Hänsch and co-workers [1], demonstrating the stabilization of

Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals

Diachronic studies in Construction Grammar have received increasing attention in the past decade. Notable larger publications include an edited volume (Bergs & Diewald, eds. 2008), a special issue of Cognitive Linguistics (Hoffmann & Trousdale, eds. 2011) and two book-length treatments (Hilpert 2013, Traugott & Trousdale 2013). Now Diachronic Construction Grammar, edited by Barðdal, Sm

The enactment of the revised Payment Services Directive (PSD2) by the European Union, has pushed banks to develop digital open banking platforms to enhance market competition and promote innovation in the banking industry. PSD2 mandates banks to offer APIs to provide access to banking data to external third-party providers (TPPs). This mandate might disrupt the role of banks since external complem

In this paper I propose an emancipation effect that may follow from the ‘reducing effect’ of frequency (Bybee 2006): if a reduced realization of an item gains in frequency, it will become conceptually independent from the full form. In a context of grammaticalization, I show that this is the case for the form gonna, which is becoming emancipated from its source form going to. I use corpus data of In this paper I propose an emancipation effect that may follow from the ‘reducing effect’ of frequency (Bybee 2006): if a reduced realization of an item gains in frequency, it will become conceptually independent from the full form. In a context of grammaticalization, I show that this is the case for the form gonna, which is becoming emancipated from its source form going to. I use corpus data of

When looking at language historically, one Ànds that many words are derived from more complex constructions. For instance, in English, never used to be ›not ever‹ (Old English ne æfre), and maybe means ›it may be that‹; a rather bizarre case is ampersand (the name of the character ›&‹), which apparently is derived from ›and per se and‹. In today’s English, we accept these words as fully legitiOn-Going Change in English Modality: Emancipation Through Frequency The English modal expressions BE going to, HAVE got to, and want to are often contracted to gonna, gotta, and wanna in spoken language. These contracted forms have gained both in frequency and conventionality in recent times.In this article, I present an investigation into the status of the contractions between phonetic reduction

Advanced Parkinson's disease (PD) is characterized by motor fluctuations including unpredictable oscillations remarkably impairing quality of life. Effective management and development of novel therapies for these response fluctuations largely depend on clinical rating instruments such as the widely-used PD home diary, which are associated with biases and errors. Recent advancements in digital hea

Climate policies are often assumed to have significant impacts on the nature and speed of energy transitions. To investigate this hypothesis, we develop an approach to categorise, trace, and compare energy transitions across countries and time periods. We apply this approach to analyse electricity transitions in the G7 and the EU between 1960 and 2022, specifically examining whether and how climat