The outcome for patients with mantle cell lymphoma (MCL) has drastically improved with new treatments directed toward the tumor immune microenvironment, where macrophages play an important role. In MCL, the presence of M2 macrophages defined by CD163 expression in diagnostic biopsies has been associated with a worse prognosis. An alternative way to assess the abundance of M2 macrophages is by meas

Background: Weight gain and hypertension are well known adverse effects of treatment with high-dose glucocorticoids. Objective: To evaluate the effects of 2 years of low-dose glucocorticoid treatment in rheumatoid arthritis (RA). Design: Pooled analysis of 5 randomized controlled trials with 2-year interventions allowing concomitant treatment with disease-modifying antirheumatic drugs. Setting: 12

Official calls for “failed” asylum seekers to leave Sweden ignore the difficulties and harms befalling stateless people who cannot return to previous countries of residence because they lack citizenship. Stateless people are caught in limbo, a position where they have no prospects of return or of attaining a residence permit in a predictable future. To learn the underlying logics and consequences Official calls for “failed” asylum seekers to leave Sweden ignore the difficulties and harms befalling stateless people who cannot return to previous countries of residence because they lack citizenship. Stateless people are caught in limbo, a position where they have no prospects of return or of attaining a residence permit in a predictable future. To learn the underlying logics and consequences

The 113I nucleus has been studied using the 58Ni(58Ni,3p) reaction at 250 MeV with the Gammasphere/ Microball facility. Gamma-ray three-and four-fold data gated by charged particle combinations were analyzed. Multipolarities of the γ rays were assigned following the angular correlation measurements. The present study is focused on the high spin properties, where the structure is dominated by 2p-2h

Nationell konsensus om identifiering och akut behandling av sepsis hos barn har hittills saknats. En arbetsgrupp utsedd av Svensk barninfektionsförening har nu sammanställt ett nationellt vårdprogram som gäller barn över 28 dagars ålder (korrigerat), utan tidigare känd immunbrist, övrig immunnedsättning eller misstänkt meningit. Vårdprogrammet har grans­kats av Svensk förening för pediatrisk akutsA task force appointed by the Swedish Society of Pediatric Infectious Diseases developed national treatment recommendations for pediatric sepsis. It is limited to previously healthy children between 28 days (corrected) to 18 years of age and presented as a flow chart. Sepsis should be thought of as a life-threatening organ dysfunction caused by a dysregulated host response to infection. If the chi

Objective: The objective was to test the hypothesis that externalizing and internalizing helpfulness beliefs and learning styles at baseline moderate panic severity and overall mental illness as short-term and long-term outcomes of two panic-focused psychotherapies, Panic Control Treatment (PCT) and Panic-Focused Psychodynamic Psychotherapy (PFPP).Method: Participants were 108 adults with DSM-IV P

While the concept of hybridisation(blending of different organisational forms, logics, or identities) in public administration has gained traction, its interplay with principal‐agent dynamics, especially within developmentcooperation, remains underexplored. Recent shifts towards the “whole‐of‐society”paradigmin Swedish development cooperation introduce complexities in the inter‐organisational dyn

Generating scientific advice to environmental management involves assessments with complex models, sparse data, and challenging empirical experiments, necessitating the integration of expert judgment with data into scientific models. To integrate expert judgement, assessors might elicit judgement by experts as quantiles, find a probability distribution that matches the quantiles, and add this info

As the field of human-agent interaction (HAI) matures, it becomes essential to acknowledge and address the differing multidisciplinary approaches that support it to favor a common interdisciplinary understanding, thus adopting a broader methodological and epistemological perspective. The field of HAI recognizes that agents are not merely isolated technologies but embedded within society. Consequen

Recent studies on Alzheimer's disease (AD) suggest that tau proteins spread through the brain following neuronal connections. Several mechanisms could be involved in this process: spreading between brain regions that interact strongly (functional connectivity); through the pattern of anatomical connections (structural connectivity); or simple diffusion. Using magnetoencephalography (MEG), we inves

This review summarizes the presentations made to a workshop entitled “Targeting Neurotrophin and Nitric Oxide Signaling to Promote Recovery and Ameliorate Neurogenic Bladder Dysfunction following Spinal Cord Injury – Mechanistic Concepts and Clinical Implications” at the International Continence Society (ICS) 2022 Vienna Meeting. Spinal cord injury (SCI; T8-T9 contusion/transection) causes impaire

Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. Proliferation of HSCs is linked to decreased reconstitution potential, and a precise regulation of actively dividing HSCs is thus essential to ensure long-term functionality. This regulation becomes important in the transplantation setting where HSCs unde

Appropriate animal models, mimicking conditions of both health and disease, are needed to understand not only the biology and the physiology of neurons and other cells under normal conditions but also under stress conditions, like nerve injuries and neuropathy. In such conditions, understanding how genes and different factors are activated through the well-orchestrated programs in neurons and othe

Computational efficiency is significantly enhanced using artificial neural network-based computing. A two-terminal memristive device is a powerful electronic device that can mimic the behavior of a biological synapse in addition to storing information and performing logic operations. This work focuses on the fabrication of a memristive device that utilizes a resistive switching layer composed of p

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of acupuncture in newborn infants undergoing painful procedures.