Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast

The mechanisms by which lime and/or phosphate addition impacts the preservation of soil organic matter (OM) are poorly understood. We explored the changes in quantity and chemistry of water-extractable organic matter (WEOM) in the bulk soil and its heavy density fraction (>1.6 g/cm3) of an unmanaged C-rich volcanic soil caused by lime and/or phosphate application. The addition of lime or phosphate

BACKGROUND: The comparative efficacy and safety of ticagrelor versus clopidogrel in older patients with myocardial infarction (MI) has received limited study. METHODS: We performed an observational analysis of all patients ≥80 years (n=14 005) who were discharged alive with aspirin combined with either clopidogrel (60.2%) or ticagrelor (39.8%) after a MI between 2010 and 2017 registered in the nat

Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. Despite this, many children suffer from incurable relapses and long-term side effects are common. Novel treatments are thus necessary

Madsen et al. show substantial long term (26 years) population demography and genetic benefits of genetic rescue of an initially inbred adder (Vipera berus) population. A post-rescue genetic bottleneck did not affect population genetic diversity. To be successful large numbers of novel alleles should be introduced into the focal population.

Recent genome-wide association studies (GWAS) identified DUSP8, encoding a dual-specificity phosphatase targeting mitogen-activated protein kinases, as a type 2 diabetes (T2D) risk gene. Here, we reveal that Dusp8 is a gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans. Male, but not female, Dusp8 loss-of-function mice, either with global or corticotropin-releasing ho

Mot bakgrund av den nuvarande och framtida kompetensbrist som kännetecknar offentlig sektor, syftar föreliggande studie till att bidra till såväl forskning som praktik genom sitt fokusera på talangförsörjning. Studien har koncentrerats dels kring två frågor: 1. Hur använder sig ett antal av Skånes offentliga organisationer av HR-driven talent management för sin talangförsörjning? 2. Hur använder s

We take a fresh look at Feynman diagrams in the spinor-helicity formalism. Focusing on tree-level massless QED and QCD, we develop a new and conceptually simple graphical method for their calculation. In this pictorial method, which we dub the chirality-flow formalism, Feynman diagrams are directly represented in terms of chirality-flow lines corresponding to spinor inner products, without the nee

Baserat på ett empiriskt material som består av enkätsvar och intervjuer samt kompletterande dokumentgranskning från landets samtliga 21 landsting och regioner(endast dokumentgranskning i två fall) tar sig den här rapporten an två syften: Att ge en heltäckande bild av de modeller för styrning, inklusive ersättningsmodeller,som tillämpas i svensk primärvård samt en analys av dessa med utgångspunkt

Det övergripande syftet i denna studie är attjämföra och analysera skillnader och likheter mellan att leda i kommunal och icke-kommunal regi för rektorer i gymnasieskolan och enhetschefer för äldreboenden. Ambitionen ärockså att beskriva hur kraven fördessa två chefskategorier har förändratssedanbörjan av 1990-talet samt vad i omvärlden som för närvarande påverkar deras situation som ledare och ch

The aethalometer model has shown to offer a fast, inexpensive and robust method for source apportionment. The method relies on aerosol light absorption attribution, mass balance of the total carbon and results in a fraction of unaccounted, residual carbon that has been associated to biogenic carbon due to its presumably non-light absorbing properties. This residual carbon and its relation to trace

The North Atlantic Oscillation (NAO) has been hypothesized to drive interannual variability in Bermudan coral extension rates and reef-scale calcification through the provisioning of nutritional pulses associated with negative NAO winters. However, the direct influence of the NAO on Bermudan coral calcification rates remains to be determined and may vary between species and reef sites owing to imp

Justice is an underlying principle and an important lens in understanding sustainable development goals (SDG). There is a need for analysis and clarification on the underlying principles of justice embedded in the SDGs. Goals such as no poverty (goal 1), zero hunger (goal 2), health and well-being (goal 3), gender equality (goal 5), affordable energy (goal 7), reduced inequalities (goal 10) as wel

As the COVID-19 pandemic intensified the global health crisis, the containment of SARS-CoV-2 infection in pregnancies, and the inherent risk of vertical transmission of virus from mother-to-fetus (or neonate) poses a major concern. Most COVID-19-Pregnancy patients showed mild to moderate COVID-19 pneumonia with no pregnancy loss and no congenital transmission of the virus; however, an increase in