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Gaming disorder (GD) is an addictive disorder with health and social impacts recognized by the World Health Organization. Although the GD treatment evidence base appear to favor cognitive behavioral therapy (CBT), knowledge of its common practice elements is limited. This systematic review critically evaluates CBT interventions for GD, encompassing individual, group, and mixed approaches, to ident
This thesis examines how private specialist clinics pursue long-term organic growth in regulated healthcare markets, using Nova Psykiatri, a Swedish provider of neuropsychiatric assessments, as a single revelatory case. The study addresses a gap at the intersection of organic growth theory, institutional theory, and private specialist care. Existing growth mode research assumes conditions of relat
In this paper we present an investigation of the dielectric response of H2O(1) and D2O(1) as a function of temperature from a supercooled state to near the boiling point. The data are obtained using THz-time domain spectroscopy, and covers the frequency range from 0 1-2 THz corresponding to 3 to 66 cm(-1). Before presenting the experimental results, we give a short introduction to some of the prop
We investigate the performance of overload control through queue length for two different web server architectures. Both of them use finite queue lengths to prevent servers from being overloaded. One architecture prioritizes requests from established sessions while the other treats all requests equally. First, we introduce queueing models for these two systems. Then, we define and explain a new we
We have investigated terahertz (THz) emission due to dynamical electron transport in wide miniband GaAs/Al0.3Ga0.7As superlattices. By noting that the time-domain THz emission spectroscopy contains the information on the step response of the electron system to the bias electric field, the obtained THz spectra were compared with the high-frequency conductivities predicted for miniband transport. Ex
A reduction method is proposed for analysing structure-acoustic and poroelastic-acoustic problems within a finite element framework. This includes systems consisting of an acoustic fluid domain coupled to a flexible structural domain and/or a porous sound absorbing material domain. The studied problem is reduced by dividing the system into a number of physical subdomains. A set of basis vectors is
OBJECTIVE. To evaluate the recurrence of foot ulcers as well as the cumulative amputation and mortality rates in diabetic patients with previous foot ulcers. DESIGN. A prospective study of consecutively presenting diabetic patients admitted to the Department of Internal Medicine because of foot ulcer with a median follow-up of 4 years. SETTING. A multidisciplinary foot-care team. POPULATION. Five-
A mutation in the cell division gene ftsK causes super-induction of sigma(70)-dependent stress defense genes, such as uspA, during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of
Popular Abstract in Swedish Det huvudsakliga bidraget i denna avhandling är approximationsalgoritmer för flera problem inom beräkningsgeometri. Den underliggande strukturen för de flesta problemen är ett geometriskt nätverk. Ett geometriskt nätverk är, i sin mest abstrakta form, en mängd noder parvis kopplade med en kant, sådan att vikten på denna kant är lika med det Euklidiska (geometriska) avstThe main contribution of this thesis is approximation algorithms for several computational geometry problems. The underlying structure for most of the problems studied is a geometric network. A geometric network is, in its abstract form, a set of vertices, pairwise connected with an edge, such that the weight of this connecting edge is the Euclidean distance between the pair of points connected. S
One problem with web servers is that they are sensitive to overload. The servers may become overloaded during temporary traffic peaks when more requests arrive than the server is designed for. Because overload usually occurs rather seldom, it is not economical to overprovision the servers for these traffic peaks, instead admission control mechanisms can be implemented in the servers. This pa per i
Most of the common modeling approaches to premixed combustion in engineering applications are either based on the assumption of infinitely fast chemistry or the flamelet assumption with simple chemistry. The level-set flamelet library approach (FLA) has shown great potential in predicting major species and heat release, as well as intermediate and minor species, where more simple models often fail
A numerical study of how changes in the micromechanical modeling affect the formability of voided metal sheets is conducted. A homogenization technique, where periodic representative volume elements are used, permits investigations of the global formability where the local material mechanisms and the microstructure are accounted for. A nonlocal material model, containing a constitutive material le
In this study, laccase from Cerrena unicolor as a highly active enzyme was adsorptively immobilized on the surface of graphite electrode. The electrode inserted into flow-injection system served as a biosensor for detection of polyphenols, including flavonoids. We used catechin hydrate, epicatechin, epicatechin gallate, prodelphinidin, and caffeic acid as a target compounds in determination. The p
Ocean waves exhibit more or less a Gaussian distribution for the instantaneous water surface height, and there is a need to develop simple models for generation of the characteristic non-Gaussian statistics, namely the asymmetric distributions of water surface height and wave slope. We argue that a simple class of non-linear oscillators can reproduce some of the characteristic features of random w
The related Axl, Sky and Mer receptor tyrosine kinases (RTKs) are increasingly being implicated in a host of discrete cellular responses including cell survival, proliferation, migration and phagocytosis. Furthermore, their ligands Gas6 and protein S are characteristically dependent on vitamin K for expression of their functions. The Gas6/Axl system is implicated in several types of human cancer a
Cystinuria is an autosomal recessive disorder characterized by increased urinary excretion of cystine and dibasic amino acids, which cause recurrent stone formation in affected individuals. Three subtypes of cystinuria have been described (type I, II, and III): type I is caused by mutations in the SLC3A1 gene, whereas nontype I (II and III) has been associated with SLC7A9 mutations. Of the 53 pati
The addition of serotonin to preparations of 32P-labelled human platelets resulted in a time- and dose-dependent hydrolysis of [32P]phosphatidylinositol 4,5-bisphosphate (PIP2) and formation of [32P]phosphatidic acid (PA). This response was inhibited by the serotonin2 receptor antagonist ritanserin, indicating that the stimulation was mediated via the serotonin2 receptor. The addition of 50-150 mM
Parkinson's disease (PD) is a multifactorial movement disorder characterized by progressive neurodegeneration. Genome-wide association studies (GWAS) have nominated over fifteen distinct loci associated with risk of PD, however the biological mechanisms by which these loci influence disease risk are mostly unknown. GWAS are only the first step in the identification of disease genes: the specific c
Introduction: Complement activation is involved in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and atypical hemolytic uremic syndrome (aHUS). Autoantibodies to complement inhibitor factor H (FH), particularly in association with deletions of the gene coding for FH-related protein 1 (CFHR1), are associated with aHUS. Methods: Autoantibodies against FH, factor I (FI) and C4b-bindin
