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Medications are of considerable help if healthcare providers are able to administer them to patients safely and appropriately. The medication use process is complex and a team of professionals – doctors, nurses, and pharmacists – work together with the patient for optimal treatment effect. The process involves many sub-processes and in every step there is a possibility for an error. Cytotoxic drug
Ett stort antal barn i Sverige uppger att de utsätts för våld eller andra övergrepp i sitt eget hem. Detta trots att principen om barnets bästa utgör en viktig grundläggande princip och ska vara avgörande i alla frågor om vårdnad, boende och umgänge. Vad som rent faktiskt utgör barnets bästa framkommer inte uttryckligen av lagtexten, utan ska bedömas utifrån varje barns enskilda situation. LagtextA significant number of children in Sweden are reporting that they are subjected to violence or other forms of abuse in their own homes. This is despite the fact that the principle of the best interests of the child constitutes an important fundamental principle and is intended to be decisive in all matters concerning custody, residence, and contact. What constitutes the best interests of the chil
När High Court of Justice avkunnade dom i målet Bell v Tavistock konstaterade domstolen att barn under 16 års ålder som lider av könsdysfori högst troligen inte kan ge ett giltigt samtycke till pubertetsbromsande hormonbehandling eller könskonträr hormonbehandling. Världen fick då ta del av berättelsen om en ung flicka som genomgått identitetsbekräftande vård och sedan ångrat sitt beslut. Denna upWhen the High Court of Justice ruled in Bell v Tavistock that children under the age of 16 suffering from gender dysphoria most likely could not consent to being treated with puberty blockers or cross-sex hormones, the verdict told the story of a young girl who underwent gender-affirming treatment and later came to regret her decision. This essay studied the decision-making capacity of children an
Introduction: This study evaluated lipid identification using mass spectrometry. Background: Three main modes of acquisition are used in mass spectrometry of lipids; data-independent acquisition (DIA), data-dependent acquisition (DDA) and targeted acquisition. DIA is the most including one, yielding a complete but complex data set, while targeted is the least including one, basing acquisition on
Sammanfattning Det immaterialrättsliga ersättningssystemet är förmodligen mer aktuellt än någonsin. Ett ökat internationellt fokus och de förändringar som bland annat IPRED-direktivet medfört är en del i detta. Dessutom har den tekniska utvecklingen under en period varit stor, sammantaget innebär detta att frågan om ersättning för immaterialrättsintrång är mycket angelägen. Immateriella rättighetSummary The sanctioning of infringements into intellectual properties is a question of severe relevance. Technical development, globalization and legal standpoints such as the Intellectual Property Rights Enforcement Directive has made the topic of this paper a much debated one. The value of intellectual properties can be immense. In fact there are quite a few cases where the most valued assets
Objective: To characterize patients with protein-losing enteropathy (PLE) diagnosed before age 18 years within a nationwide Swedish Fontan cohort. Methods: Surgical records and medical charts were reviewed for all patients born after January 1, 1993, who underwent Fontan completion before January 1, 2021. Results: Among 573 reviewed patients, 28 (4.8%) developed PLE. The median time to onset of PL
Lake water storage variations on the Tibetan Plateau (TP) serve as crucial indicators of regional hydrological dynamics and climate changes, providing more comprehensive insights than discrete measurements of lake area or water level alone. While accurate bathymetric data is fundamental for quantifying lake water storage, conventional bathymetric surveys are often constrained by logistical challen
Context. Near-infrared high-resolution échelle spectrographs unlock access to fundamental properties of exoplanets, from their atmospheric escape and composition to their orbital architecture, which can all be studied simultaneously from transit observations. Aims. We present the first results of the newly commissioned ESO near-infrared spectrograph, Near-InfraRed Planet Searcher (NIRPS), from thr
Background Drug use disorder (DUD) clusters in families due partly to shared environment, including sibling influences. Low academic achievement (AA) in adolescence increases DUD risk. This study examined whether low AA in an older sibling causally increases DUD risk in younger siblings. Methods We studied all Swedish full sibling pairs (n = 309,666) born 1972–1985 and ≤ 5 years apart. Older sibli
Purpose: The purpose of this thesis is to investigate how marketing professionals make sense of the ethical and CSR implications of using GenAI in marketing and how they assign responsibility for its potential consequences. Exploring further and understanding the gap between organizational obligations and individuals' ethical judgment is crucial to developing effective strategies for responsib
Aim: Care based on the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) has been reported to exert a positive impact on the development of prematurely born infants. The aim of the present investigation was to determine the effect of such care on the development at preschool age of children born with a gestational age of less than 32 wk. Methods: All surviving infants in a
Objective The effect of salt restriction on blood pressure is under intense debate. We tested the effect of 100 mmol salt reduction on ambulatory blood pressure (ABP) in 46 Swedish individuals, 39 of whom completed the study, using a double-blind, placebo-controlled, crossover design. Furthermore, we tested whether the basal plasma concentration of renin or N-terminal atrial natriuretic peptide (N
Endoglucanases (EGI) (endo-1,4-β-d-glucan-4-glucanohydrolase, EC 3.2.1.4, Cel7B) of Trichoderma reesei are industrially important enzymes. Thus, there is a great need for development of a primary recovery method suitable for large-scale utilization. In this study we present a concept applicable for large-scale purification of an EGI fusion protein by one-step extraction in a poly(ethylene glycol)
Smooth muscle cell (SMC)-specific deletion of transforming growth factor beta (TGF-beta) signaling would help elucidate the mechanisms through which TGF-beta signaling contributes to vascular development and disease. We attempted to generate mice with SMC-specific deletion of TGF-beta signaling by mating mice with a conditional ("floxed") allele for the type 11 TGF-beta receptor (tgfbr2(flox)) to
Introduction Aggrecanase cleavage at the (392)Glu-(393)Ala bond in the interglobular domain (IGD) of aggrecan, releasing N-terminal (393)ARGS fragments, is an early key event in arthritis and joint injuries. Here, we use a quantitative immunoassay of aggrecan ARGS neoepitope fragments in human synovial fluid to determine if this cleavage-site specific method better identifies joint pathology than
Background— The inverse relationship between pulmonary function and incidence of cardiovascular disease remains largely unexplained. This prospective study explored the hypothesis of a relationship with inflammation-sensitive plasma proteins. Methods and Results— Forced vital capacity (FVC) and plasma levels of fibrinogen, {alpha} 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were de
Objective: To estimate the occurrence of hand eczema in hairdressers in Sweden. Methods: The occurrence of hand eczema was estimated in a Swedish longitudinal retrospective cohort study including all female graduates from vocational schools for hairdressers from 1970 to 1995. A stratified sample from the general population acted as controls. A self-administered questionnaire including questions on
Aims To examine the prognostic importance of weight-change in patients with coronary artery disease (CAD), especially following acute myocardial infarction (AMI). Methods and results In 4360 AMI patients (OPTIMAAL trial) without baseline oedema, we assessed 3-month weight-change, baseline body mass index (BMI), demographics, patient history, medication, physical examination, and biochemical analys
Spondyloarthritis (SpA) is a group of interrelated inflammatory rheumatic diseases with the sub-diagnoses ankylosing spondylitis (AS), psoriatic arthritis (PsA), arthritis-associated inflammatory bowel disease (Aa-IBD), undifferentiated SpA (USpA), where stiffness and pain are key symptoms. Insidious onset back pain, morning stiffness, waking up at night, and improvement from exercise are common c
Objective: Schizophrenia is associated with premature mortality, but the specific causes and pathways are unclear. The authors used outpatient and inpatient data for a national population to examine the association between schizophrenia and mortality and comorbidities. Method: This was a national cohort study of 6,097,834 Swedish adults, including 8,277 with schizophrenia, followed for 7 years (20
