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Glycoprotein B (gB, gpUL55) is the major antigen for the induction of neutralizing antibodies against human cytomegalovirus (HCMV), making it an attractive molecule for active and passive immunoprophylaxis. The region between aa 552 and 635 of HCMV gB (termed AD-1) has been identified as the immunodominant target for the humoral immune response following natural infection. AD-1 represents a comple
Socio-economic differences in health and mortality are substantial and increasing today in many developed countries. The sources of these differences remain debated. There is an expanding literature showing that early-life conditions are linked to health in adulthood and old age. However, our knowledge about whether beneficial treatments in early life influence later health is still limited. Using
The research in this article examines audience responses to a range of factual and reality genres. It takes as a starting point that television audiences do not experience news or documentary or reality TV in isolation but as part of a range of factual and reality programmes. Factual and reality programming includes a broad understanding of non-fictional programming on broadcast television, satell
Background: There is limited evidence regarding the provision of home-based postnatal care, resulting in a weak evidence-base for policy formulation and the further development of home-based postnatal care services. Aim: To explore the structure and organisation of public hospital home-based postnatal care in Victoria, Australia. Methods: An online survey including mostly closed-ended questions wa
Several strategic interactions over social networks display both negative and positive externalities at the same time. E.g., participation to a social media website with limited resources is more appealing the more of your friends participate, while a large total number of participants may slow down the website (because of congestion effects) thus making it less appealing. Similarly, while there a
Recent research using repeat photography, long-term ecological monitoring and dendrochronology has documented shrub expansion in arctic, high-latitude and alpine tundra ecosystems. Here, we (1) synthesize these findings, (2) present a conceptual framework that identifies mechanisms and constraints on shrub increase, (3) explore causes, feedbacks and implications of the increased shrub cover in tun
Epigenetic changes may contribute substantially to risks of diseases of aging. Previous studies reported seven methylation variable positions (MVPs) robustly associated with incident type 2 diabetes mellitus (T2DM). However, their causal roles in T2DM are unclear. In an incident T2DM case-cohort study nested within the populationbased European Prospective Investigation into Cancer and Nutrition (E
We assessed whether blood lipid metabolites and their changes associate with various cardiometabolic, endocrine, bone- and energy-related comorbidities of Relative Energy Deficiency in Sport (RED-S) in female elite endurance athletes. Thirty-eight Scandinavian female elite athletes underwent a day-long exercise test. Five blood samples were obtained during the day - at fasting state and before and
The discrepancy between social and biological clock due to sleep and wake up time difference across weekdays and weekends is referred as social jetlag. The overall aim of this study is to test whether there is an association between both screen time and nighttime texting and social jetlag among 13- to 15-year-old adolescents in Sweden. This study included a cross-sectional survey in which data wer
Checkpoint blockade therapies have changed the clinical management of metastatic melanoma patients considerably, showing survival benefits. Despite the clinical success, not all patients respond to treatment or they develop resistance. Although there are several treatment predictive biomarkers, understanding therapy resistance and the mechanisms of tumor immune evasion is crucial to increase the f
Background: The importance of alerting health care systems of patients carrying multidrug-resistant bacteria (MRB) is highlighted in numerous guidelines. In the absence of electronic alert systems, notification cards are often recommended, but have rarely been evaluated. We evaluated patient experiences of receiving and using a methicillin-resistant Staphylococcus aureus (MRSA) notification card.
Populärvetenskaplig sammanfattning: Byggandet av en järnvägstunnel genom Hallandsåsen har orsakat sänkta grundvattennivåer på ett flertal platser i tunnelns närhet. Sänkta grundvattennivåer påverkar vegetationen i området och minskar även flödet i vattendragen uppe på åsen. Ett flertal våtmarker och fuktängar på Hallandsåsen har höga naturvärden och det finns därför ett stort intresse att skydda oEstablishing a railway tunnel through the mountain ridge Hallandsåsen in north-western Skåne, southern Sweden, may cause a lowered groundwater level in an approximately three kilometres wide area overlying the tunnel line. The "horst ridge" is caused by tectonic up-lift and the bedrock is rich in fissures and shear zones. There are at least two different aquifers in the area, one fissur
Forestry in Sweden suffers from browsing damage caused by large herbivores, mainly moose (Alces alces) and roe deer (Capreolus capreolus). Silviculture affects the availability of forage for these animals, and thus the browsing pressure. A step towards modeling the response of trees or to predict browsing damage is to gain more knowledge on the availability of food in forest stands. Individual gap
Popular Abstract in Swedish Denna avhandling handlar om expertinflytande och demokrati och fokuserar hur politiskt beslutsfattande i frågor med stort beroende av vetenskaplig expertis bör gå till för att vara demokratiskt. Studiens övergripande syfte är att från ett demokratiskt perspektiv värdera den svenska lagstiftningsprocessen om medicinsk genteknik, som kan ses som ett fall av beslutsfattandThis dissertation is about expert influence and democracy and focuses on how political decision-making about issues highly dependent on qualified scientific expertise should come about in order to be democratic. The primary purpose of the study is to evaluate, from a democratic perspective, the Swedish legislative process concerned with medical gene technology ? an archetypal case where the decisi
We explored possible differences in the peripheral and central pharmacokinetics of L-DOPA as a basis for individual variation in the liability to dyskinesia. Unilaterally, 6-hydroxydopamine (6-OHDA) lesioned rats were treated chronically with L-DOPA for an induction and monitoring of abnormal involuntary movements (AIMs). Comparisons between dyskinetic and non-dyskinetic cases were then carried ou
Syfte: Vårt syfte är att undersöka aktiekursutvecklingen hos statligt ägda bolag som privatiserats helt eller delvis genom en börsintroduktion eller en nyemission. Vidare syftar uppsatsen till att undersöka huruvida storleken av privatiseringen har någon betydelse för aktiekursens utveckling samt om privatiseringen kan användas som en investeringsstrategi. Metod: För att undersöka utvecklingen avPurpose: To examine the stock performance of formerly state owned enterprises that have been fully or partly sold to the market as a result of an IPO or SEO. The general purpose of this essay is to see if one can use privatizations as a investment strategy, and if the share size of the IPO or SEO can explanatory to the performance. Methodology: To be able to perform this study and fulfil the purp
Det saknas, så vitt vi vet, information om hur barn upplever svåra situationer i vardagen, och framförallt hur de upplever känslor som skam och skuld när de har en förälder med långvarig smärta. Dessutom finns det i Sverige inte någon insats inriktad på barnen under dessa förhållanden. Syftet med denna uppsats är att beskriva barnens upplevelse av skam och skuld av att leva med en långvarigt smärtThere is a lack, as far as we know, of information about how children experience difficult situations in everyday life and most importantly how they experience emotions such as shame and guilt when they have a parent with chronic pain. Moreover, in Sweden there is no effort focused on the children in these circumstances. The purpose of this study is to describe the children's experience of sha
Plant communities of set-aside agricultural land in a European project were managed in order to enhance plant succession towards weed-resistant, mid-successional grassland. Here, we ask if the management of a plant community affects the earthworm community. Field experiments were established in four countries, the Netherlands, Sweden, the UK, and the Czech Republic. High (15 plant species) and low
Background: Studies of individuals with non-cancer-related chronic pain, find that higher levels of psychological flexibility (PF) are associated with less distress, better functioning, and a better response to treatment. People diagnosed with cancer are at significantly increased risk of developing chronic cancer-related pain, the presence of which is associated with poorer health outcomes. Littl
