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Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathwa
Statins are inhibitors of the rate-limiting step of cellular cholesterol synthesis. In vitro and in vivo studies suggest that statins have anti-inflammatory properties independent of their cholesterol-lowering effects. These observations prompted us to examine the effects of pravastatin (50 mgr; M) and native or oxidized low density lipoprotein (nLDL or oxLDL) (50 mgr; g ml(minus sign1)) on primar
Protein kinase B (PKB) (also referred to as RAC/Akt kinase) has been shown to be controlled by various growth factors, including insulin, using cell lines and transfected cells. However, information is so far scarce regarding its regulation in primary insulin-responsive cells. We have therefore used isolated rat adipocytes to examine the mechanisms, including membrane translocation, whereby insuli
Dendritic cells (DCs) are potent antigen-presenting cells that might play contradictory roles during HIV-1 infection, contributing not only to antiviral immunity but also to viral dissemination and immune evasion. Although DCs are characterized by enormous functional diversity, it has not been analyzed how differentially programmed DCs interact with HIV-1. We have previously described the reprogra
Objective: Nuclear receptor interacting protein 1 (NRIP1) is an important energy regulator, but few studies have addressed its role in humans. This study investigated adipose tissue and skeletal muscle NRIP1 gene expression and serum levels in response to weight loss and exercise in humans. Methods: NRIP1 expression was measured by microarray and serum NRIP1 by ELISA and Western blotting. Skeletal
A field study was carried out to evaluate the influence of N fertilization on the growth of the external mycelium of ectomycorrhizal (EM) fungi in a Norway spruce forest in SW Sweden. Nylon mesh bags filled with sand were buried in the soil for 6-18 months and the ingrowth of mycelium was used as an estimate of EM mycelial growth. Root-isolated, trenched plots were used to estimate background grow
Wrinkle structures are microbially induced sedimentary structures (MISS) formed by cyanobacteria and are common in pre-Cambrian and Cambrian siltstones and sandstones but are otherwise rare in the Phanerozoic geological record. This paper reports the first discovery of Mesozoic wrinkle structures from Sweden. These are preserved in fine-grained and organic-rich heterolithic strata of the Lower Jur
This paper aims to study what influence different meteorological parameters have on the radial tree growth of Scots pine (Pinus sylvestris L.) in peat and mineral soils, as well as to make predictions of radial tree growth responses to changing climate based on various future climate projections. Four Lithuanian peatland complexes representing different geographical settings and hydrological condi
Monoterpenes emitted from plants have an important role in atmospheric chemistry through changing atmospheric oxidative capacity, forming new particles and secondary organic aerosols. The emission rates and patterns can be affected by changing climate. In this study, emission responses to six years of climatic manipulations (elevated CO2, extended summer drought and night-time warming) were invest
Objective. To investigate baseline levels of 12 serum biomarkers that constitute a multibiomarker disease activity test, as predictors of response to methotrexate (MTX) in patients with early rheumatoid arthritis (eRA). Methods. In 298 patients from the Swedish Pharmacotherapy (SWEFOT) clinical trial, baseline serum levels of 12 proteins were analyzed for association with disease activity based on
Study objective: We aim to describe the variability and identify gaps in preparedness and response to the coronavirus disease 2019 pandemic in European emergency departments (EDs) caring for children. Methods: A cross-sectional point-prevalence survey was developed and disseminated through the pediatric emergency medicine research networks for Europe (Research in European Pediatric Emergency Medic
The Upper Paraná River Basin (UPRB) has undergone remarkable land use and cover changes (LUCC) in recent decades. This paper analyses the hydrologic response to LUCC in the UPRB between 1985 and 2015, using the Soil and Water Assessment Tool (SWAT) model. The impacts of LUCC were examined for annual, wet, and dry season (both during calibrated and validated periods) between 1984 and 2015. The most
