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Diamond-Blackfan anaemia (DBA) is a rare congenital disease causing severe anaemia and progressive bone marrow failure. The majority of patients carry mutations in ribosomal proteins, which leads to depletion of erythroid progenitors in the bone marrow. As many as 40% of all DBA patients receive glucocorticoids to alleviate their anaemia. However, despite their use in DBA treatment for more than h

Purpose - The purpose of this paper is to find out the applicability of the many-body dissipative particle dynamics (MDPD) method for various real fluids by specifically focusing on the effects of the MDPD parameters on the MDPD fluid properties. Design/methodology/approach - In this study, the MDPD method based on van der Waals (vdw) equation of state is employed. The simulations are conducted by

Popular Abstract in Swedish Miljöhänsyn vid produktutveckling hanteras alltmer inom ramen för arbetet i certifierbara miljöledningssystem exempelvis enligt den internationella standarden ISO 14001. Detta innebär att industrin i allt högre grad sätter mål och delegerar ansvar för en kontinuerlig förbättring av produkters miljöprestanda inom ramen för speciella miljöledningsprogram för produktutveckEnvironmental considerations in product development are increasingly dealt with in the framework of certified environmental management systems such as ISO 14001. This allows industry to set objectives and assign responsibility for continuous improvement for DFE activities and environmental performance of products in DFE management programs. This thesis presents a general model for DFE management p

Transplantation of progenitor cells to the CNS has shown promise in neuronal and glial replacement and as a means of rescuing host neurons from apoptosis. Here we examined the effect of progenitor grafts on neurite extension in the degenerating retina of rd1 ( retinal degeneration 1) mice. Transplantation of retinal progenitor cells induced increased matrix metalloproteinase-2( MMP2) secretion, pa

We conducted a first pilot study on healthy women living in two countries with different dietary habits, Granada in the south of Spain and Malmo in the south of Sweden, in order to compare their levels of plasma phospholipid fatty acids, and to examine the relationship between the differences in food consumption. This study is part of a pilot study which is nested in the European Prospective Inves

A mu-ISLM (micro Immuno Supported Liquid Membrane) extraction system coupled in a sequential injection analysis (SIA) configuration, capable of simultaneous sample cleanup and enrichment was developed. The capacity of the extraction channels - donor and acceptor, respectively - were reduced from originally 10 to 1.65 mu L. The acceptor channel surface was covered with a gold layer enabling immobil

Popular Abstract in Swedish Syftet med denna undersökning är att diskutera inlärares signaler om hjälp att uttrycka sig på främmande språk, här franska, signaler som här kallas ?sollicitationer?. Undersökningen handlar om vilken roll dessa spelar för den fortsatta utvecklingen av samtalet med den infödde talaren, närmare bestämt för att utlösa s.k. SPA (Séquences Potentiellement Acquisitionnelles)The aim of this study is to discuss how ?soliciting? (non-native speakers? requests of native speakers for help in how to express themselves in a foreign language) may play a part in the triggering of SPAs (Séquences Potentiellement Acquisitionnelles or ?learning?teaching sequences?). The beneficial effect of SPAs for learning is still controversial, since no correlation has yet been shown between

The differences in fuel consumption and exhaust emissions for residential areas with different street network designs were investigated. Five areas with three different designs, including a traditional grid network and designs feeding the traffic in from a surrounding street and from a centrally located street, were considered. Differences in total fuel consumption and amount of exhaust emissions

This paper presents a numerical investigation of heat transfer from impinging swirling jets. Various turbulence models are used. Comparison with experimental data is provided. Generally the V2F model was found to perform better than other models but for small nozzle to plate distances it was hard to maintain good accuracy. The difference in performance, in terms of the Nusselt number distribution

An important component of the aircraft generated noise, especially ahead of it, is the fan noise created by the high velocity variation near the blades and the interaction of the rotating fan with the fluid. In order to predict the sound, the method used involves the acoustical analogy developed by Ffowcs Williams and Hawkings. Computation of the flow field is performed in the incompressible LES f

Designers’ work sometimes originates from a simplified view of human demands and needs, which may result in furniture that does not fulfill the user requirements. If we consider old people as one group with fairly similar needs and demands rather than have realistic images of old people as a heterogeneous group there is a tendency that it will result in misguided efforts to design for wellbeing. T

In a recently conducted interview study, some survivors of traffic victims rate their home as the most important place for remembrance, compared to both the accident site and the burial plot. The reason for this evaluation appears to be the place’s ability to bring about a positive presence of the deceased. Supported by photographs and personal objects, the home serves as a constant reminder, and

Kapitlet ger en sammanfattande bild av etableringsvillkoren för ungdomar (16-19 år) och unga vuxna (20-24 år) samt deras utanförskap i Sverige från början av 1990-talet fram till idag. Kapitlet omfattar tre avsnitt. I det första avsnittet ges en bakgrundsteckning om ungdomars etablering på den svenska arbetsmarknaden. Översikten sammanfattar forskningsresultat om arbetsmarknad, utbildning och förs

BACKGROUND: Androgen insensitivity is caused by mutations in the androgen receptor gene, and is a common etiological factor to ambiguous genitalia in the newborn. This article discusses the role of androgens in sex differentiation, the structure and function of the androgen receptor, the genetic background to androgen insensitivity as well as clinical aspects. MATERIAL AND METHODS: The article is

Normal ageing in men is associated with a physiological decline in testosterone levels, but adverse environmental or psychosocial factors may also impair testosterone secretion and cause secondary biological changes. In a number of observational or experimental studies in both animals and man, it has been possible to study the influences on gonadal function of stressful life situations. To underst

Background The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.MethodsIn a cro