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Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson's disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nature of the disease. In this study, we establish a humanized transplantation model of PD that better

Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for epidermal growth factor receptor and C─C chemokine receptor type 2 is explored in lung tumors

Erythropoiesis is intimately coupled to cell division, and deletion of the cell cycle regulator retinoblastoma protein (pRb) causes anemia in mice. Erythroid-specific deletion of pRb has been found to result in inefficient erythropoiesis because of deregulated coordination of cell cycle exit and mitochondrial biogenesis. However, the pathophysiology remains to be fully described, and further chara

AIMS: We aimed to search for associations between cognitive test results with mortality and rehospitalization in a Swedish prospective heart failure (HF) patient cohort.METHODS AND RESULTS: Two hundred and eighty-one patients hospitalized for HF (mean age, 74 years; 32% women) were assessed using cognitive tests: Montreal Cognitive Assessment (MoCA), A Quick Test of Cognitive speed, Trail Making T

Energy efficiency (EE) program administrators and policy makers have long encouraged the adoption of efficient technologies and conservation practices across all energy users and sectors. Energy users who haven’t yet participated in efficiency and conservation programs despite ongoing outreach are often referred to as “Hard-to-Reach” (HTR). These individuals or organizations can include, for insta

Osteoarthritis (OA) constitutes a major and increasing burden on patients, health care systems and the broader society. It is estimated that around a quarter of the adult population is affected by OA in the knee and hip and that the prevalence of OA will increase over the coming decades largely due to aging and adverse life-style factors. Prevention and effective care are critical to manage the ch

Global handel är ett försummat område i debatten om Antropocen, men spelar en implicit roll i många av dess definitioner. Handelns roll i att förskjuta miljöbelastning över Jorden skiljer sig väsentligt mellan det 'Columbianska utbytet' (1492-1800), den Industriella Revolutionen (~1800-1950), och den Stora Accelerationen (efter 1950). Vår systematiska översikt över forskningsläget visar emellertidGlobal trade is a neglected topic in debates on the Anthropocene, but plays an implicit role in several suggested definitions of it. Trade’s role in shifting environmental burdens around the globe differed substantially between the Columbian Exchange (1492−1800), the Industrial Revolution (~1800−1950) and the Great Acceleration (post-1950). However, this systematic state-of-the-art review shows th

Desludging is considered a key step in urban sanitation improvement. Nevertheless, in most urban unplanned settlements, desludging is performed in an unhygienic manner, risking public health. This study used a combination of qualitative and quantitative methods to analyse the underlying factors for unhygienic desludging in three urban unplanned settlements of Dar es Salaam, Tanzania. Factors for u

Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids. Methods: Participants from the GLACIER Study (Nmax = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms

Partially Premixed Combustion (PPC) has shown its potential by combining high combustion controllability with emission characteristics that are close to those of an HCCI engine. In order to get PPC the ignition delay needs to be long enough for the fuel and air to mix prior to combustion. This can be achieved by injecting the fuel sufficiently early while running with high EGR.In order to find out

Net primary production (NPP) is modeled for a coniferous forest in southern Sweden for 2001. The model is based on the light-use efficiency concept where NPP is calculated as a product of absorbed photosynthetically active radiation (APAR) and a light-use efficiency factor (ε). APAR is estimated from the fraction of APAR (FAPAR) multiplied with the daily total amount of incoming PAR. FAPAR is obta

This paper is based on a study where four go-along interviews with a total of sixteen participants were conducted in three Swedish cities. The purpose of this study was to find out how different aspects and qualities of the built environment affected different persons in terms of experiences of inclusion and exclusion and strategies used to deal with obstacles in the environment. The study highlig

On-chip light broadcasting can reduce spatial footprint and enhance energy efficiency in photonic neuromorphic systems. We demonstrate on-chip light transmission between InP nanowire photodiodes on silicon, addressing the gap towards complete nanoscale photonic integrated circuits.

Background: Acute kidney injury (AKI) is a serious complication after lung transplantation, but the reported incidence varies in the literature. No data on AKI have been published from the Swedish lung transplantation program. Methods: The aim of our study was to investigate the incidence, perioperative risk factors, and effects of early postoperative acute kidney injury (Kidney Disease Improving

Accurate prediction of crack growth and strength in glued timber joints and components can be achieved by using cohesive laws in constitutive models. These laws represent the traction-separation relationship that measures the stress transmitted between crack faces in a cohesive zone, and can be obtained directly from experiments. However, studies on measuring the cohesive laws of wood adhesive bon

We study the Higgs boson decay into dark matter (DM) in the framework of freeze-in at stronger coupling. Even though the Higgs-DM coupling is significant, up to order one, DM does not thermalize due to the Boltzmann suppression of its production at low temperatures. We find that this mechanism leads to observable Higgs decay into invisible final states with the branching fraction of 10% and below,

Around one-fourth of the global population lacks access to clean fuels and technologies for cooking, most of them living in low- and middle-income countries. Reliance on rudimentary and inefficient biomass cookstoves results in high pollutant concentrations that adversely affect the health of those exposed to indoor air pollution, the environment, and the climate. In this study, we systematically

Decolonizing development has animated conferences, grants, and programs for several years, a response to the ineffectiveness of much aid and ongoing colonial legacies. Yet, little attention has gone to the education of development practitioners and its impacts on their professional practices. We lack practical approaches for decolonizing our classrooms, especially approaches based on experiences o

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