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A combined sample preparation and sample presentation device, Integrated Selective Enrichment Target (ISET), consisting of an array with 96 perforated nanovials is described. Each perforated nanovial can be filled with soild-phase extraction media for purification and concentration of biomolecules prior to mass spectrometry. The ISET platform provides an efficient, economic and generic sample trea

Accelerated cell aging, indexed in peripheral leukocytes by telomere shortness and in peripheral blood mononuclear cells (PBMCs) by telomerase activity, has been reported in several studies of major depressive disorder (MDD). However, the relevance of these peripheral measures for brain indices that are presumably more directly related to MDD pathophysiology is unknown. In this study, we explored

Germ layer formation and primary axis development rely on Fibroblast growth factors (FGFs). In Xenopus, the secreted serine protease HtrA1 induces mesoderm and posterior trunk/tail structures by facilitating the spread of FGF signals. Here, we show that the serpin Protease nexin-1 (PN1) is transcriptionally activated by FGF signals, suppresses mesoderm and promotes head development in mRNA-injecte

SimSWE is a library of components for modeling and simulation of software engineering processes. It consists of a generic, implementation independent description of the components and a reference implementation using the MATLAB® / Simulink® environment. By providing ready-to-use building blocks for typical functionality, the library should facilitate and ease the use of simulation to analyze softw

Popular Abstract in Swedish Modellering och simulering är etablerade tekniker för att lösa designproblem inom många olika ingenjörsdiscipliner idag. Dedicerade språk, såsom Modelica, och effektiva mjukvaror finns också tillgängliga. I denna avhandling presenteras en språklig utvidgning av Modelica, Optimica, som är avsedd för formulering av dynamiska optimeringsproblem. För att demonstrera användnModeling and simulation are established techniques for solving design problems in a wide range of engineering disciplines today. Dedicated computer languages, such as Modelica, and efficient software tools are available. In this thesis, an extension of Modelica, Optimica, targeted at dynamic optimization of Modelica models is proposed. In order to demonstrate the Optimica extension, supporting sof

Popular Abstract in Swedish ”Att leva med cancer som äldre, livskvalitet och upplevelse av mening” Cancer drabbar företrädesvis äldre personer och är en sjukdom som blir vanligare i takt med det stigande antalet äldre i befolkningen. Cancer hos äldre innebär en komplex situation eftersom åldrandet är präglat av stora individuella förändringar med ökande sjuklighet, nedsatt funktionell förmåga, föThe overall aim of this thesis was to investigate quality of life in people aged 75 and older with cancer in relation to age, gender, presence and type of complaints, comorbidity, living conditions, perceived economic situation, sense of coherence, receiving help for daily living and social resources. The aim was also to investigate older people’s experiences and the meaning of living with cancer

A study is presented of the impact on science data from extremely large telescopes of a transformation of wavelength base for optimization of actuator architecture from 2 200 to 1250 nm. From the optical path difference (OPD) data for Euro50, we transform to E-ELT OPDs. We compute the corresponding power spectrum, in which we simulate a higher actuator density via high-pass filtering to convert fr

The rapid progress in scanning probe microscopy (SPM) techniques in the last decade has induced an increasing need for manufacturing advanced SPM tips. One important case is conductive and transparent tips. For such tips, only a few techniques have been proposed. which are either expensive or have poor reproducibility. We here propose a simple and cheap sol-gel technique to prepare fibers with a s

Between 1991 and 1994 the number of beds in the surgical clinic at a central hospital in Southern Sweden was cut back by almost 50%. To develop the nursing care and to control the effects of the budgetary cuts, an intervention, including nursing care development, of an organization that would secure continuity in the nurse-patient relationship, individually planned care and quality assurance for a

In this article the medialization of everyday life is discussed, as it appears in the norwegian novelist Jan Kjaerstads "Förföraren" (The Seducer). I mainly focus upon the intermedia aspects between literature and other art and media forms, such as TV, film, music, etc. Another aspect discussed in the article is the cluster of connections between Norway/Scandinavia and the rest of the world, which

The aim of this study was to investigate use and need for assistive devices (AD) in a cross-national European sample. Data from the ENABLE-AGE research project were utilised involving very old persons in Sweden, Germany, Latvia, Hungary and the United Kingdom. Of the total sample 65% reported that they had and used one or more AD, and 14% reported unfilled need for AD. The most commonly used AD we

This dissertation explores how the school subject Swedish is constructed for various groups of upper secondary school students and how the meeting between teacher and pupils is embodied in a range of Swedish subjects. The overall aim of the study is to illustrate why the teaching of Swedish in the classes under investigation takes place the way it does, as well as to discuss possible changes on a

Today, innovation is a key word for many universities, as it constitutes an important part of most universities’ public and scientific interaction with society. Many universities are striving to increase the number of innovations spun out. At many universities, innovations are thought of as being sprung from research projects and generated by researchers. However, Sandström (2014) claims that whil

Aviation fuel is a petroleum product that fulfills the Standard Specification for Aviation Turbine Fuels. Crude oil has been the raw material for production of aviation fuels for many years. Since the availability of crude oil is predicted to be limited in the future, alternative raw materials for aviation fuels are highly desirable. A Swedish company, Oroboros AB, has developed a novel clean synt