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Flow diverter devices are small stents used to divert blood flow away from aneurysms in the brain, stagnating flow and inducing intra-aneurysmal thrombosis which in time will prevent aneurysm rupture. Current devices are formed from thin (∼25 μm) wires which will remain in place long after the aneurysm has been mitigated. As their continued presence could lead to secondary complications, an absorb
Excess heat is generated from different industrial processes and from urban infrastructure (sewage water, transport, datacentres and buildings). Thirty-five percent of the European energy demand for heating and cooling could be met by excess heat. Today, however, this energy reserve is barely exploited. There are known barriers to excess heat recovery but limited information on stakeholder interac
The linear inverse problem associated with the standard model for hyperspectral image recovery from CASSI measurements is considered. This is formulated as the minimization of an objective function which is the sum of a total variation regularizer and a least squares loss function. Standard first-order iterative minimization algorithms, such as ISTA, FISTA and TwIST, require as input the value of
Modeling metalloproteins often requires classical molecular dynamics (MD) simulations in order to capture their relevant motions, which in turn necessitates reliable descriptions of the metal centers involved. One of the most successful approaches to date is provided by the "cationic dummy model", where the positive charge of the metal ion is transferred toward dummy particles that are bonded to t
Diverse organophosphate hydrolases have convergently evolved the ability to hydrolyse man-made organophosphates. Thus, these enzymes are attractive model systems for studying the factors shaping enzyme functional evolution. Methyl parathion hydrolase (MPH) is an enzyme from the metallo-β-lactamase superfamily, which hydrolyses a wide range of organophosphate, aryl ester and lactone substrates. In
This work investigates the design of beampatterns for frequency diverse arrays-multiple-input multiple-output (FDA-MIMO) in the range-angle plane, in order to improve the approximation of a desired beampattern. Recognizing that the energy radiated by the array cannot be locked at a fixed range and angle, the beampattern is designed for the equivalent beampattern at the receiving end, differing fro
Bioresorbable photonic implants are emerging as potential material choice for interstitial theranostic and monitoring applications. They gradually dissolve within the physiological environment in a clinically relevant period, eliminating the need for extraction surgeries. In the present study, we tested the suitability of in-house fabricated bioresorbable optical fibres based on calcium phosphate
Selectivity control of aniline oxidation and low reactant conversion in traditional synthesis methods are great challenges, and it is desirable to develop a green, low-cost and highly efficient catalytic route toward value-added products. Herein, an Rb-promoted Fe/CeO2 nanocatalyst was prepared to understand the effects of Rb-promoter on the catalytic performance for the selective oxidation of ani
BACKGROUND: The incidence of colorectal cancer (CRC) in individuals of fertile age is increasing. Oxaliplatin is a cornerstone treatment in the adjuvant setting for stage III and high-risk stage II CRC. Limited data exist on possible side effects of oxaliplatin on fertility and gonadal function. More data is needed to guide possible fertility preservation procedures and aid evidence-based fertilit
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional characterization of mouse and human dendritic cells (DC) from lymphoid organs, and various nonlymphoid tissues. Within this article, detailed protocols are prese
Therapies derived from substances of human origin (SoHOs) such as organs, cells, and tissues provide life-saving or life-changing treatment for millions of people worldwide each year. However, many people lack timely access to SoHO-based therapies because of insufficient supplies of these exceptional health resources and/or broader barriers in access to healthcare. Despite well-established governm
Abstract in ItalianQuesta esposizione propone in maniera teoretica una critica dell’esagerazione come approccio utile a qualsiasi filosofia che si occupi dei cosiddetti temi esistenziali. Si segue l’esempio dell’esagerazione per proporre un pensare oltre l’essere, in contrasto con la questione dell’essere senza esagerazione. Infine, si propone la critica propria dell’esagerazione come atteggiamentThis theoretical exposition proposes the critique of exaggeration as the approach to any philosophy that deals with the so-called existential themes. It provides the example of exaggeration in thinking beyond being in contrast to the question of being without exaggeration. Finally, it proposes the critique of exaggeration as a philosophical attitude that resists the temptation to seriously engage
Background: Sick leave due to stress-related mental ill health increases in society. In occupational therapy, occupational balance is considered important for experiencing health and well-being. Thus, knowledge regarding occupational balance and occupational value constitute essential parts of occupational therapists’ work with people suffering from occupational ill health. Objective: The aim of t
The least absolute shrinkage and selection operator (LASSO) algorithm is a promising method for sparse source location in time–division multiplexing (TDM) multiple–input, multiple– output (MIMO) radar systems, with notable performance gains in regard to resolution enhancement and side lobe suppression. However, the current batch LASSO algorithm suffers from high– computational complexity when deal
The use of molecular data to study the evolutionary history of organisms has revolutionized the field of systematics. Now with the appearance of high throughput sequencing (HTS) technologies, more and more genetic sequence data are available. One of the important sources of genetic data for phylogenetic analyses has been mitochondrial DNA. The limitations of mitochondrial DNA for the study of phyl
Propionic acid (PA) is a naturally occurring short chain fatty acid produced by microbial fermentation of the indigestible foods in the intestine, having a positive effect on the gastrointestinal health. PA inhibits the growth of pathogenic bacteria and molds; hence it is widely used as preservative for food, feed and grains. It is also used as a component in several industrial products like polym
