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Impairment of normal hematopoiesis and leukemia progression are 2 well-linked processes during leukemia development and are controlled by the bone marrow (BM) niche. Extracellular matrix proteins, including laminin, are important BM niche components. However, their role in hematopoiesis regeneration and leukemia is unknown. Laminin α4 (Lama4), a major receptor-binding chain of several laminins, is
Purpose: Accuracy investigation of volumetric navigators for motion correction, with emphasis on geometric EPI distortions at ultrahigh field. Methods: High-resolution Dixon images were collected in different head positions and reconstructed to water, fat, T2*, and B0 maps. Resolution reduction was performed, and the T2* and B0 maps were used to apply effects of TE and EPI distortions to simulate
Organic electrochemical transistors formed by in operando electropolymerization of the semiconducting channel are increasingly becoming recognized as a simple and effective implementation of synapses in neuromorphic hardware. However, very few studies have reported the requirements that must be met to ensure that the polymer spreads along the substrate to form a functional conducting channel. The
The performance of structural timber connections is of utmost importance since they control the global response of the building. A ductile failure mechanism on the global scale is desirable, especially in the design of structures in seismic areas, where dissipative components in which ductile failure modes need to be ensured are considered. Therefore, the knowledge of possible brittle failure mode
This paper presents a two-stage procedure to create a surface integrity predictor. The first stage includes data clustering, which allows to evaluate the achievable surface quality. The second stage consists in training the model to predict which cluster the machined surface will belong to. To demonstrate the applicability, an experimental plan for machining of Inconel 718 in milling was developed
Contemporary hybrid zones act as natural laboratories for the investigation of species boundaries and may shed light on the little understood roles of sex chromosomes in species divergence. Sex chromosomes are considered to function as a hotspot of genetic divergence between species; indicated by less genomic introgression compared to autosomes during hybridization. Moreover, they are thought to c
We conducted an extensive geophysical field campaign using ground-penetrating radar (GPR) and electrical resistivity tomography (ERT) in a former military area at the archaeological site of Nora (South-Western Sardinia). The purpose was to identify a Phoenician, and then Punic and Roman, necropolis of considerable interest, subject of a long-term investigation and currently under excavation. In th
Ramjet propulsion is commonly preferred to power supersonic and hypersonic vehicles for cruising faster than Mach 3. This is an elegant solution owing to the lean architecture which does not embody any rotating parts. Although the geometry of the engine is simple as compared to turbine based configurations, the flow physics through the engine duct is quite complex and the flow speeds modulate betw
Background: Population-based register data could be used to improve our knowledge of patients surgically treated for foot and ankle disorders. The quality register Swefoot was recently created to collect surgical and patient-reported data of foot and ankle surgery. This manuscript aims to describe the development and current use of the register. Methods: The development of Swefoot started in 2014
In this article, we investigate public support for eco-social policies combining goals of social justice and ecological sustainability. Eco-social policies contribute both to providing a social floor or redistributing resources to where they are needed and to respecting an ecological ceiling by keeping human activities within ecological limits. We discuss five such policies and highlight arguments
Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials. Here we discuss in detail further research needed to be performed before widespread use of BBMs. We already now recommend use of BBMs as (pre-)screeners to identify individuals likely to have AD patholo
Contemporary research and teaching on global environmental politics (GEP) draw upon many approaches to understanding the ways in which states and societies respond to transboundary environmental problems (see Chapter 2). Approaches that emphasize the state (see Chapter 7) and international organizations (see Chapter 8) derive in a straightforward way from scholarly work in international relations
This paper studies how degraded material properties in near proximity to the cut edge influence the torque performance of an axial-flux induction machine. The magnetically degraded areas are characterized using a layering approach, where the magnetic hysteresis curve describing the material is remodeled so that the field strength required to reach a specific value of magnetic flux density is incre
Nondestructive testing of composite materials is important in aerospace applications, and mm-wave imaging has been increasingly used for this purpose. Imaging is traditionally performed using Fourier methods, with inverse methods being an alternative. This communication presents a mm-wave imaging method with an inverse approach intended for nondestructive testing of singly curved composite panels
