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Objectives. To study possible nerve regeneration of a damaged auditory nerve by the use of stem cell transplantation. Methods. We transplanted HNPCs to the rat AN trunk by the internal auditory meatus (IAM). Furthermore, we studied if addition of BDNF affects survival and phenotypic differentiation of the grafted HNPCs. A bioactive nanofiber gel (PA gel), in selected groups mixed with BDNF, was ap
The spatial distribution of an anti-cancer drug and its intended target within a tumor plays a major role on determining how effective the drug can be at tackling the tumor. This study provides data regarding the lateral distribution of sunitinib, an oral antiangiogenic receptor tyrosine kinase inhibitor using an in vitro animal model as well as an in vitro experimental model that involved deposit
The taphonomic and diagenetic processes by which organic substances are preserved in animal remains are not completely known and the originality of putative metazoan biomolecules in fossil samples is a matter of scientific discussion. Here we report on biomarker information preserved in a fossil whale bone from an Oligocene phosphatic limestone (El Cien Fm., Mexico), with a focus on fatty acyl com
Over the last years an expanding family of small non-coding RNAs (sRNA) has been identified in eukaryotic genomes which behave as sequence-specific triggers for mRNA degradation, translation repression, heterochromatin formation and genome stability. To achieve their effectors functions, sRNAs associate with members of the Argonaute protein family. Argonaute proteins are segregated into three para
During the latest early Campanian, a diverse vertebrate assemblage inhabited the shallow coastal waters of the Kristianstad Basin, southernmost Sweden. The taxon-rich fauna includes numerous species of sharks, rays, chimaeroids, bony fish, mosasaurs, plesiosaurs, aquatic birds, crocodiles, and turtles. Vertebrate fossils have been found at several localities within the basin, representing at least
A methodology for estimation of the unknown physical parameters in a detailed model for chromatographic processes is proposed. The model describes the concentration of the solute in the mobile phase and considers external/internal mass transfer resistance. The external volume and its mixing effect are also considered. The unknown model parameters estimated are the bed void, the axial dispersion co
Disease-specific epitope profiles of glutamic acid decarboxylase (GAD)65 autoantibodies (GAD65Ab) were studied in slowly progressive type 1 (insulin-dependent) diabetes mellitus (SPIDDM) and acute onset type 1 (insulin-dependent) diabetes mellitus (AIDDM) using seven kinds of GAD65/67 chimeric molecules. Sera obtained from Japanese SPIDDM (n = 17) and AIDDM (n = 46) patients followed prospectively
The small nuclear genome of the pufferfish, Fugu rubripes (order Tetraodontiformes), makes this species highly interesting for genome research. In order to establish the phylogenetic position of the Tetraodontiformes relative to other teleostean orders that might also have a reduced nuclear genome size, we have sequenced the mitochondrial (mt) genome of the pufferfish. The gene order, nucleotide c
Abstract In the given report, scientific results gathered at the Alfred- Wegener- Institut für Polar- und Meeresforschung (AWI) within an ScD contract are summarized. The AWI is the German large scale research facility for polar- and marine research. In January 1992 +he new research de- partment at Potsdam has been established with the section Physics und Chemistry of the Atmosphere. 1t coordinate
1. Wind-damaged trees, following the severe storm of 1999, are compared with data from a 50-year monitoring of Draved Forest, Denmark, to assess differing causes of mortality through time in an unmanaged semi-natural forest. Species-specific mortality characteristics and the changing effects of tree size and growth rate (diameter increment) on mortality through time are also investigated. 2. Storm
The material in Swedish herbaria previously identified as Hieracium sublividum (Dahlst.) Johanss. was revised using both the traditional taxonomical approach and PCA analysis based on 44 morphological characters. Only about half of the specimens did belong to H. sublividum s. stricto (known from the provinces Småland, Öland and Östergötland). Three new species were revealed and are described anew
The electronic transitions of 16 neutral thermal double donors (TDD1-TDD16) and of nine positively charged species (TDD1-TDD9) were observed previously in infrared absorption spectra. An earlier species (TDD0) was detected, however, only in persistent photoconductivity and Hall effect studies. In the present work, lines related to the electronic transitions from the ground to excited states in bot
Through-plane morphologies of multiblock copolymers based on poly(arylene ether sulfone)s were investigated by transmission electron microscopy (TEM) and through-plane conductivity measurements using a 4-probe method. The measured results showed that proton conductivity increased with a longer block length and that the optimal block length ranged from 5 to 7 K. TEM cross-sectional images also supp
This study considered trends in the intergenerational transmission of social assistance (SA) among young adults in Finland, Norway and Sweden during the 2000s. Comparable administrative register data-sets enabled us to compare year by year the social assistance recipiency of 20-year-old adults in the period 1999–2008, together with information on their parents' social assistance recipiency at the
As corporations are going global, they are increasingly confronted with human rights challenges. As such, new ways to deal with human rights challenges in corporate operations must be developed as traditional governance mechanisms are not always able to tackle them. This article presents five different views on innovative solutions for the relationships between business and human rights that all b
To investigate the relationship between the individual thrombin-cleavages in factor V (FV) and the generation of FXa-cofactor activity, recombinant FV mutants having the cleavage sites eliminated separately or in combination were used. After thrombin incubation, the ability of the FV variants to bind FXa and support prothrombin activation was tested. The interaction between FVa and FXa on the surf
Objective To assess the application of a quality control scheme for total prostate-specific antigen (PSA) as used for participants of the European Randomized Study for Screening of Prostate Cancer (ERSPC) during 1996-2002. Methods From 1996, the first complete year being 1997, an external scheme was organized by the Dutch Quality Assessment Foundation especially for the ERSPC. This scheme consists
