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AIMS: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) have increased prevalence of atrial arrhythmias indicating atrial involvement in the disease. We aimed to assess the long-term evolution of P-wave indices as electrocardiographic (ECG) markers of atrial substrate during ARVC progression. METHODS AND RESULTS: We included 100 patients with a definite ARVC diagnosis according
A recurrent concern in nature conservation is the potential competition for forage plants between wild bees and managed honey bees. Specifically, that the highly sophisticated system of recruitment and large perennial colonies of honey bees quickly exhaust forage resources leading to the local extirpation of wild bees. However, different species of bees show different preferences for forage plants
Background: The ZBTB16-RARA fusion gene, resulting from the reciprocal translocation between ZBTB16 on chromosome 11 and RARA genes on chromosome 17 [t(11;17)(q23;q21)], is rarely observed in acute myeloid leukemia (AML), and accounts for about 1% of retinoic acid receptor-α (RARA) rearrangements. AML with this rare translocation shows unusual bone marrow (BM) morphology, with intermediate aspects
Background Triptolide is an active natural product, which inhibits cell proliferation, induces cell apoptosis, suppresses tumor metastasis and improves the effect of other therapeutic treatments in several cancer cell lines by affecting multiple molecules and signaling pathways, such as caspases, heat-shock proteins, DNA damage and NF-ĸB. Purpose We investigated the effect of triptolide towards NF
Immune cell-derived cytotoxic pathways have been implicated in antitumor immune responses. The goal of this study is to characterize how these cytotoxic pathways influence ovarian cancer development. We have utilized the TgMISIIR-TAg transgenic mouse model which expresses the transforming SV40 TAg in the ovary, leading to spontaneous development of ovarian tumors that closely mimic human epithelia
The eutrophication problems in lakes on the Yangtze Plain of China have attracted global concern. However, a comprehensive assessment of the eutrophication status and its evolution is still lacking for these regional lakes, mostly because of technical difficulties and/or insufficient data to cover the large region. Our study attempts to fill this knowledge gap by using the entire archive of remote
BACKGROUND: Previous research suggests that Tanzanian MSM might prefer consulting pharmacies and drugstores, rather than public healthcare services, when in need of STI medicines and treatment. Yet, few studies have explored the experiences of providing services to MSM clients among those working at pharmacies and drugstores and examined what challenges they encounter in providing these services.
Increasing landscape complexity can mitigate negative effects of agricultural intensification on biodiversity by offering resources complementary to those provided in arable fields. In particular, grazed semi-natural grasslands and woody elements support farmland birds, but little is known about their relative effects on bird diversity and community composition. In addition, the relative importanc
Background: The UICC TNM 7th edition introduced stage groups for anal cancer which in 2019 has not yet come into general use. The new TNM 8th edition from 2016 defines 7 sub-stages. Background data for these changes are lacking. We aimed to investigate whether the new classification for anal cancer reliably predict the prognosis in the different stages. Patients and methods: The Nordic Anal Cancer
Cartridge cases are often the sole items left behind after a shooting incident and DNA traces from these can identify persons connected to the shooting. However, the chance of retrieving usable DNA profiles from cartridge cases is limited, due to the low amounts of deposited DNA and subsequent DNA loss associated with the firing process. In the current study, we set out to increase the DNA recover
Purpose Prostate motion during radiation therapy (ie, intrafraction motion) can cause unwanted loss of radiation dose to the prostate and increased dose to the surrounding organs at risk. A compact but general statistical description of this motion could be useful for simulation of radiation therapy delivery or margin calculations. We investigated whether prostate motion could be modeled with a ra
Introduction: The prevalence of arthropathy in moderate haemophilia A (MHA) and B (MHB) is not well known. Aim: We evaluated joint health in Nordic patients in relation to their treatment modality. Methods: A cross-sectional, multicentre study covering MHA and MHB in Sweden, Finland and Norway. Arthropathy was evaluated by ultrasound (HEAD-US) and Haemophilia Joint Health Score (HJHS). Results: We
Stroke är en mycket vanlig sjukdom och idag räknar man med att det finns över 140 000 drabbade i Sverige som lever med varierande grad av funktionell nedsättning. Prognosen efter stroke påverkas av många olika faktorer varav flera tidigare inte fått så mycket uppmärksamhet. Den här avhandlingen ämnar ge en heltäckande bild av långtidsprognosen och varje delarbete fokuserar på olika viktiga aspekteBackground: Stroke is a major cause of mortality and disability. Prognosis is constantly evolving and is affected by multiple factors, many of which have not previously been thoroughly analyzed. This thesis aims to provide an updated and comprehensive description of long-term prognosis after stroke, specifically exploring key factors such as comorbidity (Study II), pre-stroke functional dependency
År 2014 antogs direktiv 2014/65EU, även kallat MiFID II. Direktivet reglerar bland annat hur finansiella institut ska organisera sin verksamhet för att skydda kundernas intresse i de fall kunderna handlar med finansiella instrument. Direktivet är skrivet med ett starkt kundskydd och harmoniserad inre marknad som mål. Två år senare, 2016, antogs direktiv 2016/97, även kallat IDD. IDD är motsvarandeThe financial crisis 2008 revealed several weaknesses in the regulation on the financial markets. It was evident that a new, stricter, regulation was needed to be created. Directive 2014/65EU, MiFID II and directive 2016/97, IDD, is a part of the new financial regulation. MiFID II regulates how financial institutes can interact with investors, when investors seek to buy or sell financial instrumen
Öga för öga, tand för tand är en straffrättslig princip som myntades av kung Hammurabi i Babylonien kring år 1700 före Kristus genom Hammurabis lag. Principen om öga för öga, tand för tand innebär att den som orsakat skada ska lida samma skada. Svensk straffrätt har gått från resonemanget att ”ont ska botas med ont” till straff och skadestånd i pengar och därför finns inte principen om öga för ögaChapter 5 article 2 of the Property Formation Act reads that the person who forfeitsland shall be compensated with land primarily. This means that the principal rule isthat land shall be compensated with land, but when this is not deemed appropriated compensation in money is acceptable. Furthermore, the paragraphmeans that the Surveying Authority (LM) may decide against the land owners wish that c
This master thesis in library and information science is centered around two reading circles taking place at the libraries of Swedish upper secondary schools. The aim of the thesis is to study how the participants (ages 16-18) in the reading circles reflect on their own reading practices and their identities as readers. One main point of the thesis is that reading circles are forms of reading comm
A major problem in the development of intelligent hearing aids is often referred to as the cocktail party problem. It describes the remarkable ability of the human brain of filter out unwanted sounds in a noisy environment, while focusing on a single talker or conversation. Without the ability to select and enhance a specific sound source of choice while suppressing the background, the hearing aid
The low-carbon benefits and emissions savings from circular economy (CE) strategies are not yet well understood, yet are crucial for global development within Planetary Boundaries. Using the mineral fraction of waste incinerator bottom ash (MIBA) as construction material in road construction is one application of a CE strategy that could lead to environmental gains by substituting energy-intensive
Recycling reduces the need for new raw materials and greenhouse gas emissions. In addition, the new waste legislation from the EU and the Swedish government imposes higher recycling requirements on Swedish municipalities. Starting from January 1, 2024, it will be mandatory for all EU member states to separately collect food waste through curbside collection. The Swedish government has also decided
