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Systematic microbial production of optically active dissolved organic matter in subarctic lake water

The ecology and biogeochemistry of lakes in the subarctic region are particularly sensitive to changes in the abundance and optical properties of dissolved organic matter (DOM). External input of colored DOM to these lakes is an extensively researched topic, but little is known about potential reciprocal feedbacks between the optical properties of DOM and internal microbial processes in the water.

Benchmarking subcellular localization and variant tolerance predictors on membrane proteins

Background: Membrane proteins constitute up to 30% of the human proteome. These proteins have special properties because the transmembrane segments are embedded into lipid bilayer while extramembranous parts are in different environments. Membrane proteins have several functions and are involved in numerous diseases. A large number of prediction methods have been introduced to predict protein subc

High-throughput amplicon sequencing and stream benthic bacteria : Identifying the best taxonomic level for multiple-stressor research

Disentangling the individual and interactive effects of multiple stressors on microbial communities is a key challenge to our understanding and management of ecosystems. Advances in molecular techniques allow studying microbial communities in situ and with high taxonomic resolution. However, the taxonomic level which provides the best trade-off between our ability to detect multiple-stressor effec

Disentangling the Arcturus stream

Context. The Arcturus stream is an over-density of stars in velocity space and its origin has been much debated recently without any clear conclusion. The (classical) dissolved open cluster origin is essentially refuted; instead the discussions try to distinguish between an accretion, a resonant, or an external-perturbation origin for the stream. As kinematic structures are observational footprint

Immunohistochemical detection of the pro-apoptotic Bax∆2 protein in human tissues

The pro-apoptotic Bax isoform Bax∆2 was originally discovered in cancer patients with a microsatellite guanine deletion (G8 to G7). This deletion leads to an early stop codon; however, when combined with the alternative splicing of exon 2, the reading frame is restored allowing production of a full-length protein (Bax∆2). Unlike the parental Baxα, Bax∆2 triggers apoptosis through a non-mitochondri

Creativity within urban gardening at times of emergency

Creativity often erupts as individuals reshape tradition in the light of changing historical circumstances. This presentation focuses on creativity within urban gardening projects as an answer to worries about ecological crisis. It builds on ethnographic research during 2017-2018 among urban gardeners in the Malmö-Lund area, Sweden. The interlocutors, especially project coordinators, expressed a s

Decentralization: Resolve or Hide the Problem?

Governance of common resources such as water calls for rethinking structure, legal frameworks and property rights. In order to promote the decentralization of water governance, Water User Associations (WUAs) were created in many countries, such as India and Turkey, to operate and maintain irrigation systems as well as take over the responsibility of water distribution among water users. Despite pr

Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin

Lubricin (PRG4) is a mucin type protein that plays an important role in maintaining normal joint function by providing lubrication and chondroprotection. Improper lubricin modification and degradation has been observed in idiopathic osteoarthritis (OA), while the detailed mechanism still remains unknown. We hypothesized that the protease cathepsin G (CG) may participate in degrading lubricin in sy

Relapse Risk and Loss of Lifetime After Modern Combined Modality Treatment of Young Patients With Hodgkin Lymphoma : A Nordic Lymphoma Epidemiology Group Study

PURPOSE: Estimates of short- and long-term survival for young patients with classic Hodgkin lymphoma (cHL) are of considerable interest. We investigated cHL prognosis in the era of contemporary treatment at different milestones during the follow-up. PATIENTS AND METHODS: On the basis of a Nordic cohort of 2,582 patients diagnosed at ages 18 to 49 years between 2000 and 2013, 5-year relapse risks a

Chemical signaling and insect attraction is a conserved trait in yeasts

Yeast volatiles attract insects, which apparently is of mutual benefit, for both yeasts and insects. However, it is unknown whether biosynthesis of metabolites that attract insects is a basic and general trait, or if it is specific for yeasts that live in close association with insects. Our goal was to study chemical insect attractants produced by yeasts that span more than 250 million years of ev

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes

To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using

A new one-step multiplex PCR assay for simultaneous detection and identification of avian haemosporidian parasites

Accurate detection and identification are essential components for epidemiological, ecological, and evolutionary surveys of avian haemosporidian parasites. Microscopy has been used for more than 100 years to detect and identify these parasites; however, this technique requires considerable training and high-level expertise. Several PCR methods with highly sensitive and specific detection capabilit

Temperature and age effects on latitudinal growth dynamics of the commercially valuable gadoid Northeast Arctic saithe (Pollachius virens)

It is well known that marine fish dynamics relate with climate variability, and predicting future population developments have become increasingly urgent with on-going climate change. One approach in widespread populations is to study how individuals from different parts of the distribution area respond to climate, thereby testing for potential resilience in terms of local adaptions against enviro

A combined approach to assess the impacts of Ecological Focus Areas on regional structural development and agricultural land use

The 2013 reform of the Common Agricultural Policy (CAP) introduced compulsory ‘greening’ measures with the goal to mitigate environmental degradation caused by intensive agriculture. This paper aims to investigate how the implementation of the Ecological Focus Areas (EFA) obligation will affect regional agricultural development, the economic performance of farms and land use (including choices of

Consequences of intensive forest harvesting on the recovery of Swedish lakes from acidification and on critical load exceedances

Across much of the northern hemisphere, lakes are at risk of re-acidification due to incomplete recovery from historical acidification and pressures associated with more intensive forest biomass harvesting. Critical load (CL) calculations aimed at estimating the amount of pollutants an ecosystem can receive without suffering adverse consequences are dependent on these factors. Here, we present a m

Linking multiscale deformation to microstructure in cortical bone using in situ loading, digital image correlation and synchrotron X-ray scattering

The incidence of fragility fractures is expected to increase in the near future due to an aging population. Therefore, improved tools for fracture prediction are required to treat and prevent these injuries efficiently. For such tools to succeed, a better understanding of the deformation mechanisms in bone over different length scales is needed. In this study, an experimental setup including mecha

Prediction of hip and hand fractures in older persons with or without a diagnosis of periodontitis

Purpose: In a prospective study, we assessed if a diagnosis of osteoporosis and periodontitis could predict hip and hand fractures in older persons. Materials and methods: Bone density was assessed by a Densitometer. Periodontitis was defined by evidence of alveolar bone loss. Results: 788 Caucasians (52.4% women, overall mean age: 76 years, S.D. +/- 9.0, range: 62 to 96) were enrolled and 7.4% ha

Influence of precessing vortex core on flame flashback in swirling hydrogen flames

This study examines the influence of vortex core precession on flame flashback of swirl-stabilised hydrogen flames. Theoretical considerations suggest that the angular velocity of a swirling flow is reduced as vortex precession causes it to acquire an eccentric motion around the central axis of the burner. The eccentric motion of the vortex generates a secondary flow, which is thought to reduce th

The Effect of Education on the Assessment of Optic Nerve Head Photographs for the Glaucoma Diagnosis

Background: To evaluate the effect of one lesson of continuing medical education (CME) of subjective assessment of optic nerve head appearance on sensitivity and specificity for the diagnosis of glaucoma. Methods: Ophthalmologists and residents in ophthalmology attending an international glaucoma meeting arranged at Malmo University Hospital, Malmo, Sweden, were asked to grade optic nerve head (ON