Filetype
Identification of genomic rearrangements by microarrays or short-read sequencing frequently lacks information about the exact architecture and breakpoints of variants due to technical limitations. Independent verification of complex structural variants (SVs) is often performed using custom targeted assays, making confirmation of clinically relevant findings time consuming and laborious. In this st
Background: Standardized definitions of autoimmune disease (AD) are lacking. Therefore, we aim to propose a definition of AD for register-based research and estimate the burden of AD in Sweden as registered in the National Patient Register (NPR) from 1980 to 2023. Methods: Leveraging the NPR, we defined AD as having at least two relevant International Classification of Diseases (ICD) codes represe
Motor sequence learning research has been primarily concerned with simple frequentist patterns, thereby neglecting the motor system's ability to handle uncertainty and non-deterministic environments. In this study, we combine methods from motor neuroscience and neurolinguistics to study how probabilistic systems are acquired during motor learning. Two groups of young adults practiced a probabilist
Objectives: To date, there are no clear guidelines in the literature on protocols for pediatric vestibular testing, and approaches may differ between teams. The objective of this study was to establish a consensus guideline for the minimum pediatric vestibular tests that should be conducted in both expert and non-expert centers. Methods: The leadership group identified 21 international experts in
This paper assesses the communication and the use of climate scenarios at the science–science and science–policy interface in Finland, Sweden and Norway. It is based on document analysis and stakeholder questionnaires. The questionnaires targeted three stakeholder groups, all engaged in the communication and the use of climate scenario information: climate scenario producers; impact, adaptation an
A causal inference framework was developed to investigate crop responses to agricultural drought by integrating meteorological data, Sentinel-2-derived data, and soil property maps. To account for crop rotation, soil, and topographical variables, propensity score matching was employed to estimate drought-induced yield losses at the field level for selected periods. The Plant Phenology Index (PPI)
Background: To investigate a patient-level single imputation approach for patient reported outcomes (PROs) that express similar contents or associated PROs, where a PRO whose value is missing at a particular timepoint is substituted by another PRO whose value is available at the same timepoint. Methods: We performed a simulation study on registry-based spondyloarthritis data to explore the potenti
Background: It is unclear whether thyroid hormone levels are associated with the risk of mortality, cardiovascular disease (CVD) events, or cancer in men with normal TSH. Objectives: We analyzed if serum free T4 (FT4) or TSH is associated with the risk of mortality, incident CVD events, or cancer in Swedish men. Methods: Elderly men (n = 1801; mean age 75 years) in the Gothenburg and Malmö subcoho
Patients with chronic lymphocytic leukemia (CLL) have an impaired response to vaccination, which calls for improved vaccination strategies. This study aimed to evaluate antibody persistence 5 years after pneumococcal vaccination and response to revaccination. Seventy-four CLL patients and 31 controls, all primary immunized with 13-valent conjugated pneumococcal vaccine (PCV13) or 23-valent polysac
Aims: Individuals with type 1 diabetes (T1D) are typically diagnosed at a young age and exposed to lifelong hyperglycaemia. Despite improved metabolic control, the risk of vascular complications remains challenging. However, some individuals remain free from developing major diabetic complications even after long duration, so-called “escapers”. This study investigated transcriptomic biomarkers lin
Zircons from anatectic melts of the country rocks of three Proterozoic mafic-ultramafic intrusions from the Sveconorwegian Province in SW Sweden were microanalyzed for U-Th-Pb and rare earth elements. Melting and interaction of the wall rocks with the intrusions gave rise to new magmas that crystallized zircon as new grains and overgrowths on xenocrysts. The ages of the intrusions can be determine
This paper describes a measurement of the jet radius dependence of the dijet momentum balance between leading back-to-back jets in Formula Presented of Formula Presented collisions collected in 2018 and Formula Presented of Formula Presented collisions collected in 2017 by the ATLAS detector at the LHC. Both datasets were collected at Formula Presented TeV. Jets are reconstructed using the anti-Fo
Purpose: To define the curriculum content for two interactive learning courses on age-related macular degeneration (AMD): (1) an advanced course tailored for general ophthalmologists and (2) a basic course for non-ophthalmologist healthcare staff. This initiative aims to establish a national consensus on the educational framework for AMD management among general ophthalmologists in Denmark. Method
In this work, we investigate the cryogenic performance of hafnia-based ferroelectric capacitors with and without an aluminum oxide (ALO) interlayer, comparing conventional metal-ferroelectric-metal (MFM) structures to metal-ferroelectric-insulator-metal (MFIM) counterparts. Devices employing Hf0.5Zr0.5O2 as the ferroelectric layer were characterized from 300 K down to 10 K, targeting temperature r
One of the major recent breakthroughs has been the discovery of the last major merger to happen in the history of the Milky Way. Around 10 Gyr ago, the galaxy Gaia Enceladus with an estimated ∼10% of the Milky Way mass, fell into the potential of our Galaxy, bringing a large amount of stars that can be identified through their unique chemical and kinematic signatures. Simulations have long predict
Multi-wavelength thermo-optical analysis (MW-TOA) and Raman spectroscopy are commonly used methods to study soot sampled on filters, in terms of carbon content, nanostructure, and absorption properties. In this work, these techniques were combined to study how these characteristic properties of soot change in premixed flames, 1) at various flame heights during soot maturation and 2) as a result of
The main purpose with this Master's thesis has been to through a case study investigate and analyze the music library activity at the Public Library in Lund, in order to find out according to which ideas and principals this activity is run by. It also discusses how you at the music department handle your task as intermediary of music and how well this coincides with the users expectations. To
Marine pollution is an increasingly serious environmental problem. Close to half of the total marine pollution comes from vessels and the pollutant that is the most obvious is oil. Fortunately, this problem has been recognized almost all over the world. Vessel-source oil pollution has attracted large numbers of international legislation, as well as national. As we will see in this paper, it often
När jag hade flöjtlektioner på kulturskola värderades inte musiken efter genrer. Min upplevelse var att flera olika genrer förekom lika ofta på lektionerna. När jag senare sökte in till musikhögskolan och var tvungen att välja genre rubbades denna bild och jag frågade mig vad min roll som flöjtpedagog kommer vara. Ska jag nischa mig inom en genre, eller ska jag kunna lära ut lite av varje? SyftetWhen I had flute lessons at the community school of music and art, music was not valued according to genres. My experience was that several different genres were equally common in the lessons. When I later applied to Malmö Academy of Music, and had to choose a genre, this idea was disrupted and I asked myself what my role as a flute teacher would be. Should I specialize myself within a genre, or s
Objectives: To describe and compare the consumption of dairy products in cohorts included in the European Prospective Investigation into-Cancer and Nutrition (EPIC). Methods: Data from single 24-hour dietary recall interviews collected through a highly standardised computer-based program (EPIC-SOFT) in 27 redefined centres in 10 European countries between 1995 and 2000. From a total random sample
