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Multimodal transportation in the European continent is an integral part of cross border trade and in particular the use of sea and river carriers. The phenomenon of short sea shipping has reached a level of importance of which all European states must take cognisance. One of the policies associated with this issue is the development of the motorways of the sea. While Ukraine is not yet a part of t
This document describes the field- and driving simulator experiments carried out within Work-package 3.2 (Evaluation of in-car speed limiters). In both the field study and the simulator experiment positive effects of the speed limiter were found in terms of large speed reductions (particularly in urban areas), reduced speed variance and better speed adaptation on critical places (approaches, curve
Popular Abstract in Swedish Råttans urinblåsa har studerats ur olika aspekter, sedan antingen ett standardiserat avflödeshinder åstadkommits eller hälften av urinblåsans nervförsörjning avlägsnats. Avflödeshindret har åstadkommits genom att en silkestråd knutits runtom urinröret så att det försnävats. Genom att en knappt mm-vid metallstav knutits om samtidigt och sedan avlägsnats, har graden av avMedian micturition volume decreased early after partial outlet obstruction, 24 hrs total obstruction and hemidenervation. Degeneration release of transmitter may explain this, assuming that bladder wall distension causes nerve degeneration. Micturition pressure decreased simultaneously in the partially denervated and 24 hrs obstructed groups, probably due to the reduced number of functionally inta
A DNS study of propagation of either an infinitely thin passive interface or a reaction wave of a nonzero thickness in forced, constant-density, statistically stationary, homogeneous, isotropic turbulence was performed by solving Navier-Stokes equations and either level set or reaction-diffusion equation, respectively, with all other things being equal. The simulations covered a wide range of cond
Background: Use of bio-based diesel is increasing in Europe. It is currently produced from oilseed crops, but can also be generated from lignocellulosic biomass such as straw. However, removing straw affects soil organic carbon (SOC), with potential consequences for the climate impact of the biofuel. This study assessed the climate impacts and energy balance of biodiesel production from straw usin
Prior treatment exposure in patients with relapsed/refractory multiple myeloma may affect outcomes with subsequent therapies. We analyzed efficacy and safety according to prior treatment in the phase 3 TOURMALINE-MM1 study of ixazomib-lenalidomide-dexamethasone (ixazomib-Rd) versus placebo-Rd. Patients with relapsed/refractory multiple myeloma received ixazomib-Rd or placebo-Rd. Efficacy and safet
Background: Allergy and asthma are closely linked. Inhalation of allergen induces an early allergic response (EAR) within the airways of allergic asthmatic subjects, which is followed by a late allergic response (LAR) in approximately 50% of the subjects. The LAR is defined as a drop in forced expiratory volume in 1 second (FEV1) from baseline usually occurring 4-8 hours after exposure and is beli
Rodents homozygous for autosomal leptin receptor gene mutations not only become obese, insulin resistant, and hyperleptinemic but also develop a dysregulated immune system. Using marker-assisted breeding to introgress the Koletsky rat leptin receptor mutant (lepr-/lepr-), we developed a novel congenic BBDR.lepr-/lepr- rat line to study the development of obesity and type 2 diabetes (T2D) in the Bi
Multiple analogs of parathyroid hormone, all of which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism. Although ligands such as abaloparatide, teriparatide (hPTH 1-34 [TPTD]), and long-acting PTH (LA-PTH) show distinct biologic effects with respect to skeletal and mineral metabolism endpoints, the mechanistic basis for these clinically-important
ObjectiveComputerized decision‐support tools may improve diagnosis of acute myocardial infarction (AMI) among patients presenting with chest pain at the emergency department (ED). The primary aim was to assess the predictive accuracy of machine learning algorithms based on paired high‐sensitivity cardiac troponin T (hs‐cTnT) concentrations with varying sampling times, age, and sex in order to rule
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by clonal proliferation of primitive hematopoietic stem cell. The median age at diagnosis is 55 to 60 years with less than 10% of patients younger 20 years. Incidence of CML in children in the Czech Republic is 0.106 cases/100 thousands per year. Here we report outcome of 38 pediatric patients (median age 12.5 years; range 1.8
The impact of age and 24-h ambulatory blood pressure (ABPM) on arterial stiffness and carotid intima-media thickness (cIMT) in ischemic stroke patients younger than 60 years of age is poorly explored. A total of 385 acute ischemic stroke patients (aged 49.6±9.7 years, 68% men) were prospectively included and grouped in younger (15–44 years, n = 93) and middle-aged (45–60 years, n = 292). Arterial
Background: The aim of the study was to develop and test an artificial intelligence (AI)-based method to improve the quality of [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) images. Methods: A convolutional neural network (CNN) was trained by using pairs of excellent (acquisition time of 6 min/bed position) and standard (acquisition time of 1.5 min/bed position) or sub-standard
Purpose: Monte Carlo (MC) modelling techniques can assess the quantitative accuracy of both planar and SPECT Nuclear Medicine images. It is essential to validate the MC code's capabilities in modelling a specific clinical gamma camera, for radionuclides of interest, before its use as a clinical image simulator. This study aimed to determine if the SIMIND MC code accurately simulates emission image
Background: Previous studies have investigated [18F]-fluorocholine (FCH) positron emission tomography with computed tomography (PET/CT) in primary staging of men with intermediate or high-risk prostate cancer and have generally shown high specificity and poor sensitivity. FCH PET/CT is not recommended for the primary staging of metastases in the European guidelines for prostate cancer. However, it
OBJECTIVE To use islet autoantibody titers to improve the estimation of future type 1 diabetes risk in children. RESEARCH DESIGN AND METHODS Prospective cohort studies in Finland, Germany, Sweden, and the U.S. followed 24,662 children at increased genetic or familial risk to develop islet autoimmunity and diabetes. For 1,604 children with confirmed positivity, titers of autoantibodies against insu
Objective: To prospectively assess anorectal dysfunction using patient-reported outcomes using validated questionnaires, manovolumetry and endoanal ultrasound before and 12 months after RC. Patients and methods: From 2014 to 2019, we prospectively included 44 patients scheduled for RC. Preoperatively and 12 months after surgery, 41 patients filled in a low anterior resection syndrome score (LARS-s
If calcifuges are forced to grow on a calcareous soil, they usually develop chlorosis. However, total leaf iron (Fe) does not often correlate well with Fe deficiency symptoms. The extraction of 'active' Fe by 1 M HCl or Fe chelators, e.g., 1,10-phenanthroline, may reflect the relation between chlorosis and Fe-concentration in the leaves better than total Fe does. Extraction of 'active' Fe from lea
Dytiscus latissimus (Coleoptera Dytiscidae) is an endangered diving beetle throughout its range. It is one of the two species of Dytiscidae listed in Annex II of the Habitats Directive, IUCN red list and in many national level legislations and therefore strictly protected. The conservation of endangered species first of all requires an assessment of their population size. Until now, a method has n
Popular Abstract in Swedish Idag lagras allt fler kartor digitalt och nya metoder krävs för att förbättra denna digitala hantering. Ett område som studerats under senare tid är automatiska metoder för kartografisk generalisering. Kartografisk generalisering innebär att man förenklar informationen i en karta för att göra den mer lättläst i den önskade skalan. Denna avhandling beskriver en optimerinCartographic generalisation is the process of simplifying a representation to suit the scale and purpose of a map. As such, generalisation has always been a central part in map production. This thesis is a contribution to the ongoing work on automating cartographic generalisation. Two topics are treated: optimisation methods in graphic generalisation, and propagation of updates between cartographi
