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Abstract Objectives: The study aimed to test the construct validity, factor structure and reliability of the 11-item version of the Tampa Scale for Kinesiophobia (TSK-11, Swedish version) among older people (65+) with chronic pain. Design: Methodological study. Subjects: 433 participants with chronic pain (mean age 74.8, 65-98 years) completed postal questionnaires. 264 of the participants complet

Popular Abstract in Swedish Lokal läkemedelsstatistik – ett verktyg för att identifiera problemområden och att bedöma effekter av information och utbildning om läkemedel. Det finns behov att studera läkemedelsförskrivning och läkemedelsanvändning och dessas samband med och effekter på hälsa, sjuklighet och överdödlighet. Det är också önskvärt att kunna använda individdata. I Sverige är det i allmAims: 1) To assess if drug sales data indicate differences in morbidity, mortality, socio-economic conditions and deviating prescribing habits among physicians; 2) to identify areas for educational interventions and to analyse changes in prescribing after educational activities. In addition, an effort was made to estimate differences between pharmacy sales and purchases by the population, and the

1. The European Water Framework Directive requires the determination of ecological status in European fresh and saline waters. This is to be through the establishment of a typology of surface water bodies, the determination of reference (high status) conditions in each element (ecotype) of the typology and of lower grades of status (good, moderate, poor and bad) for each ecotype. It then requires

Popular Abstract in Swedish Alla levande celler har förmåga att känna av och på olika sätt anpassa sig till sin omgivning, antingen de ensamma utgör en hel organism eller är en av många miljarder celler i ett stort djur. Varje enskild cell kan bara ta emot en begränsat mängd olika sorters signaler och bara reagera på ett likaledes begränsat antal sätt. Den en- eller fåcelliga organismen är därmed The G protein-coupled receptors form one of the largest families of proteins involved in signalling between cells. It contains receptors for molecules as diverse as biogenic amines, glycoproteins and enzymes. The manuscripts included in this thesis together describe the initial characterisation of a previously unknown receptor of this class. A DNA fragment was cloned from a mouse genomic library.

Popular Abstract in Swedish Relationen mellan högre utbildning och nyutbildade akademikers arbetsliv har diskuterats intensivt sedan början av 1990-talet. Å ena sidan förekommer ständiga klagomål om en påstådd diskrepans mellan den kompetens de nyutbildade besitter och den kompetens som potentiella arbetsgivare kräver. Å andra sidan har representanter för högre utbildning betonat universitetens obThe issue of higher education and its relation to the working life of graduates has been intensely discussed since the beginning of the 1990’s. There have been constant complaints about an alleged mismatch between graduate competence and competence required by potential employers, regardless of field. On the other hand, representatives of higher education have stressed the independent role of univ

Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland. It occurs in several molecular forms in the blood and assays have been developed to measure free PSA and PSA in complex with alpha-1-antichymotrypsin (PSA-ACT). Higher proportions of free PSA (PSA-F/T) in blood are found in subjects with benign prostatic hyperplasia (BPH) as compared to cancer patients. Utilizing imm

Popular Abstract in Swedish Nuklearmedicin bygger på användning av radioaktiva spårämnen, enligt principen av George de Hevesy, för kartläggning av global och regional funktion hos organ eller patologisk vävnad. Nuklearmedicin inkluderar även användningen av ”Magic bullet”-konceptet enligt Ehrlich där en molekyl används som bärare av radionuklider för att få en radiobiologisk terepeutisk effekt påNuclear medicine is based on the radiotracer principle of George de Hevesy and the magic bullet concept by Ehrlich and focuses on the diagnosis, the treatment of diseases and the investigation of normal states within the human body using radiopharmaceuticals. A radiopharmaceutical is an atom or a chemical compound in which one or several atoms are replaced with a radionuclide. Several diagnostic a

Viruses are ubiquitous in all environments where life is present, also in aquatic environments. The fish-pathogenic virus, Infectious pancreatic necrosis virus (IPNV), has generally been studied because it causes high mortality amongst hatchery-reared salmonids in aqua culture facilities around the world. Today, no efficient vaccine is available to protect the fish from becoming infected. The viru

This dissertation is an analysis of the culture and lifestyle of women in the middle classes in small towns in southern Sweden between 1790 and 1870, from a gender perspective. The study builds on local material from Lund, Karlshamn and Kristianstad, and is principally made up of the private letters and diaries of a large number of people. The thesis attempts to shed light on relationships, values

The mineralogy, petrology, and fluid inclusion chemistry of two charnockite patches within a distance of 4-5 km of the Varberg magmatic charnockite intrusion, SW Sweden, are investigated and described utilizing SEM, EMPA, and fluid inclusion microthermometry. Garnet-clinopyroxene (890-930 degrees C), garnet-amphibole (600-800 degrees C), and garnet-biotite (670-860 degrees C) Fe-Mg exchange thermo

Beta cell apoptosis is a hallmark of diabetes. Since we have previously shown that galectin-3 deficient (LGALS3/) mice are relatively resistant to diabetes induction, the aim of this study was to examine whether beta cell apoptosis depends on the presence of galectin-3 and to delineate the underlying mechanism. Deficiency of galectin-3, either hereditary or induced through application of chemical

Objective: To study serum type I interferon (IFN) activity in patients with early systemic sclerosis (SSc). Method: Serum type I IFN activity was measured in 33 consecutive patients with SSc and a disease duration of < 2 years and in 13 healthy individuals by calculating a type I IFN score according to the induction of six IFN-α regulated genes in a reporter cell line. Results: Twenty-seven per ce

Survival after in-hospital pulseless electrical activity (PEA) cardiac arrest is poor and has not changed during the last 10 years. Effective chest compressions may improve survival after PEA. We investigated whether a mechanical device (LUCAS (TM)-CPR) can ensure chest compressions during cardiac arrest according to guidelines and without interruption during transport, diagnostic procedures and i

Objective-Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results-We studied a European cohort of 525 men and 655 women (mean age, 44 +/- 8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects

The interplay between diet and immune-parameters which could affect type 1 diabetes (T1D) pathogenesis is not sufficiently clarified. Intestinal upregulation of the activating receptor NKG2D(CD314) and its ligands is a hallmark of celiac disease (CD). However, the direct effect of gluten on NKG2D expression is not known. We studied, by FACS (lymphoid tissues) and RT-qPCR (intestine and pancreatic

Isoprene is emitted from many terrestrial plants at high rates, accounting for an estimated 1/3 of annual global volatile organic compound emissions from all anthropogenic and biogenic sources combined. Through rapid photooxidation reactions in the atmosphere, isoprene is converted to a variety of oxidized hydrocarbons, providing higher order reactants for the production of organic nitrates and tr

A sediment sequence was taken from a closed, high altitude lake (informal name Olive-backed Lake) in the central mountain range of Kamchatka, in the Russian Far East. The sequence was dated by radiocarbon and tephrochronology and used for multi-proxy analyses (chironomids, pollen, diatoms). Although the evolution of Beringian climate through the Holocene is primarily driven by global forcing mecha

Phosphodiesterase 5 (PDE5) is associated with migraine pathophysiology, stroke recovery and vasospasm treatment The potential vascular interplay of PDE5 inhibitors sildenafil, tadalafil and UK-114,542 was studied by intra- versus extra-luminal administration in rat middle cerebral arteries in vitro and on middle meningeal arteries in vivo. By Western blot PDE5 was detected in both cerebral and men