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Background: Available evidence suggest that perceptions or ratings of the neighborhood, e.g. as being green, walkable or noisy, are important for effects on health and wellbeing, also after controlling for objective measures of identical or similar features. When evaluating effects of the perceived environment, it is important that measurement properties and the reliability of the environmental ra

It is generally recognised that agricultural intensification has lead to simplification of landscape structure, but it has not been clarified if this is a ubiquitous relationship. That is, it has been an open question whether agricultural intensity and landscape simplicity should be regarded as one single or as two separate dimensions. To evaluate this we analysed landscape data in 136 different 1

Acute cardiovascular events, most commonly caused by rupture of an atherosclerotic plaque, lie behind one third of all deaths worldwide. Atherosclerosis is an inflammatory disease of large and medium sized arteries driven by retention of lipid in the arterial wall. Inflammatory activity in the plaque is believed to be an important driving force behind plaque progression and rupture. However it is

Almost every day a school fire occurs in Sweden. In most cases arson is the cause of the fire. The losses for these arson fires are considerable. In this report a number of cases studies have been conducted on school fires in Sweden. The project envisages obtaining more knowledge on the technical factors that influence the spread of fires with arson in schools. Solutions to mitigate the fire sp

The use of ground-source heat pumps for heating buildings and domestic hot water in dwellings is increasing rapidly in Sweden. The heat pump extracts heat from the ground by a U-pipe in a vertical borehole. In order to reduce the electricity demand in the system, the combination with solar collectors is introduced. This system may be designed in many ways and the advantages differ a lot. Solar hea

While many laboratory studies have focused on the short term effects of biochar addition to soil), there have been comparatively few tracing its longer term effects in the field. This study investigated the multiyear impact of biochar on crop performance and soil quality with specific emphasis on carbon (C) and nitrogen (N) cycling over a 3 y period. Biochar was added to an agricultural field at 0

Head Computed Tomography (CT) imaging is still a commonly obtained diagnostic test for patients with minor head injury despite availability of clinical decision rules to guide imaging use and recommendations to reduce radiation exposure resulting from unnecessary imaging. This prospective multi-center observational study of 251 patients with suspected mild to moderate traumatic brain injury (TBI)

Background: The link between squamous cell cervical carcinoma and human papillomavirus (HPV) 16/18 is well established, but the magnitude of the risk association is uncertain and the importance of other high-risk HPV (HRHPV) types is unclear. Methods: In two prospective nested case-control series among women participating in cytologic screening in Sweden, we collected 2,772 cervical smears from 51

Objective The primary objective of this study was to assess the impact of atomoxetine in combination with psychoeducation, compared with placebo and psychoeducation, on health-related quality of life (HRQL) in Swedish stimulant-naive pediatric patients with attention deficit/hyperactivity disorder (ADHD). HRQL results will be presented elsewhere. Here, psychoeducation as well as efficacy and safet

Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing-based quantitative analysis of DNA methylation in 98 GC cases and 64 controls ne

Melanoma genomes contain thousands of alterations including: mutations, copy number alterations, structural aberrations, and methylation changes. The bulk of this variation is stochastic and functionally neutral, with only a small minority representing "drivers" that contribute to the genesis and maintenance of tumors. Drivers are often directly or inversely correlated across tumors, reflecting th

Background: The rate of biological ageing is individual and represents the steady decrease in physiological and mental functions. Adverse social factors have been shown to influence this process. Self-perceived early ageing (SEA) might be a useful indicator of early biological ageing and increased mortality risk. The aim of this population-based study was to identify markers of SEA, including telo

Receding glaciers are among the most obvious changes caused by global warming, and glacial meltwater entering lakes generally forms plumes of particles. By taking vertical samples along a horizontal gradient from such a particle source, we found that photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) attenuated 20-25% faster close to the inflow of suspended particles compare

Insulin sensitivity declines in overweight and obese individuals and, under normal conditions, insulin secretion adaptively increases which in healthy non-diabetic subjects maintains normal glycemia. This adaptation is best described by the disposition index derived from modeling of insulin and glucose data from an intravenous glucose tolerance testing (IVGTT). One caveat of the IVGTT is that basi

Popular Abstract in Swedish Hur man undviker att bli trakasserad på flicksländornas vis Tidigare forskningsresultat har visat att hos honor i de flesta djurarter begränsas fortplantningkapacitet av hur mycket tid och energi de kan lägga på sina avkommor. Hos hanar, å andra sidan, begränsas fortplantningskapacitet av hur många honor de kan para sig med. Då kan man dra slutsatsen att hanar ska försThis study has involved investigation of number of populations of the damselfly Ischnura elegans over several years, looking at frequency changes over time, morphological differences between the sexes and the morphs, differences in growth rate and development time, differences in fecundity between the morphs, and genetic differentiation between populations. I. elegans is a small annual damselfly w

Reflections of Fire. Images of the First World War in Sweden This thesis investigates the cultural impact of the First World War in Sweden, and how it shaped Swedish images and narratives about war and neutrality from 1914 to 1935. In line with Paul Fussell, George L. Mosse, and Jay Winter, among others, I discuss the symbolic, discursive aspects of the war at a popular, everyday level. The theor

Popular Abstract in Swedish Yttersta domen blev det favoriserade motivet då man under 1700-talet dekorerade de västsvenska kyrkornas innertak. VARFÖR kom just helvetesdetaljen att uppta allt större utrymme? Syndens straff utvisas här som en evig vistelse i ett kvalfyllt helvete. Snart var det stort nog att symboliskt rymma hela församlingen. Härifrån rungar varningar, hot skallar medan eldsprutandDuring the18th century, the Swedish orthodox Church faced considerable problems with dissension and indifference. One important means of coping with the situation was the decision to have the ceilings of the churches painted in brilliant oil-paint. The appropriate theme for the didactic purpose was Time’s End, Christ’s second coming in order to judge mankind. Almost every church in the South-west

Popular Abstract in Swedish När en skada på ett kärl uppstår sätts blodkoagulationen igång. En rad reaktioner mellan olika proteiner, såsom proenzymer, enzymer och kofaktorer sker då på negativt laddade ytor som exponeras i samband med skadan. Därigenom omvandlas flytande blod till levrat blod och kärlskadan täpps igen. Faktor V är en viktig komponent i blodkoagulationen. I koagulationsprocessens Coagulation factor V (FV) is activated by thrombin through proteolytic cleavage at Arg-709, Arg-1018 and Arg-1545. Upon thrombin activation, the active form of factor V (FVa) is formed. FVa functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin during coagulation. Recently, it was shown that in addition to being a precursor form of the procoagulant FVa, FV functions as a

Pressure on reducing prices and a market demand for customisation and shorter production runs give cause for investigating alternatives to conventional printing. Traditional technologies, such as flexography and offset, are all using static printing forms, while a digital printing unit prints information directly from the data file. Hence, the latter alternative makes it possible to produce short

Popular Abstract in Swedish Neuoroblastom är en av de tumörformer som oftast drabbar små barn. Eftersom tumörer lyckligtvis är relativt ovanliga hos barn drabbas inte fler än i genomsnitt 14 barn årligen av neuroblastom i Sverige. Tyvärr finns dock, trots den effektiva behandling som kunnat arbetas fram för många andra barncancerformer, idag ingen verksam behandling att tillgå för så många som hälNeuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. Expression of trkA and trkC is linked to f