Search results

Popular Abstract in Swedish Basic Fibroblast Growth Factor (bFGF) är en av flera tillväxtfaktorer som finns lagrad i benvävnaden. bFGF framkallar celldelning och tillväxt hos många olika celltyper, däribland benceller (osteoblaster) och broskceller. bFGF kan stimulera till nybildning av blodkärl och även benvävnad. I denna avhandling undersökes om utifrån tillfört bFGF kan öka benbildning och vävnBasic Fibroblast Growth Factor (bFGF) is one of the endogenous factors found in bone matrix. bFGF is a mitogen for many cell types, including osteoblasts and chondrocytes. It can stimulate angiogenesis and osteoblast gene expression. The purpose of this study was to investigate whether exogenous bFGF can stimulate the formation of bone in bone grafts and in a bone graft substitute. All experiments

Emerging lines of evidence indicate that the cutaneous human papillomavirus (HPV) types that belong to the genus Betapapillomavirus (beta HPV) are involved in the development of nonmelanoma skin cancer. Unlike the situation for mucosal HPV types, highly sensitive and reliable methods to identify characterized cutaneous HPV types in a single assay are limited. Here, we describe a novel one-shot met

Popular Abstract in Swedish Varje dag bildas ca 10^12 nya blodceller i människokroppen. Denna enorma produktion av celler utgår från benmärgen och pågår under hela vårt liv. Ytterst sett är denna process beroende av en till antalet liten cellpopulation av sk blodstamceller eller hematopoietiska stamceller. Den enorma potential som vilar i detta system illustreras av det faktum att en enda blodstamHematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and are ultimately responsible for the continuous production of blood cells throughout life. The regulation of HSCs in vivo is tightly regulated by both intrinsic and extrinsic factors. The Smad-signaling pathway is an evolutionary conserved signaling circuitry with critical functions during embryogenesis and throu

Classical conditioning of motor responses, e.g., the eyeblink response, depends on the cerebellum. In the theoretical works of David Marr (1969) and James Albus (1971), it was proposed that Purkinje cells in the cerebellar cortex learn to associate the neutral conditioned stimulus with the response. Since their work, several studies have provided data that are consistent with this suggestion, but

OBJECTIVE—Sleep deprivation in healthy men has been experimentally found to result in disturbances in glucose metabolism and in sympathovagal imbalance. The aim of the present study was to investigate whether sleep disturbances and elevated resting heart rate are associated with increased risk of developing diabetes. RESEARCH DESIGN AND METHODS—A group of 6,599 initially healthy, nondiabetic men

In 1997, a temporally shifted population of Thaumetopoea pilyocampa (Den. & Schiff.), was recorded for the first time in a restricted area of the oldest National Pine Forest of Portugal-the National Pine Forest of Leiria. This new population larval development takes place during the summer (summer population-SP), while in the normal population it takes place during the winter (winter populatio

Background. Partial correction of renal anaemia with erythropoietin improves quality of life (QoL). We aimed to examine if normalization of haemoglobin with epoetin alfa in pre-dialysis and dialysis patients further improves QoL and is safe. Methods. 416 Scandinavian patients with renal anaemia [pre-dialysis, haemodialysis (HD) and peritoneal dialysis patients] were randomized to reach a normal ha

In many species, population sex ratios have far-reaching consequences for a wide variety of population-level and behavioural processes and can directly influence sexual selection through differential effects on male and female mating behaviour. Although sex ratios are often treated as more or less stable population characteristics, recent theoretical evidence suggests that sex ratios fluctuate und

The rat stomach is rich in endocrine cells. The acid-producing (oxyntic) mucosa contains ECL cells, A-like cells, and somatostatin (D) cells, and the antrum harbours gastrin (G) cells, enterochromaffin (EC) cells and D cells. Although chromogranin A (CgA) occurs in all these cells, its processing appears to differ from one cell type to another. Eleven antisera generated to different regions of rat

Intestinal alkaline sphingomyelinase (alk-SMase) digests sphingomyelin and the process may influence colonic tumorigenesis and cholesterol absorption. We recently identified the gene of human alk-SMase and cloned the cDNA. Cross-species screening of homology in GenBank found a hypothetical rat protein, XP_221184, with 491 amino acid residues, which shares 73% identity with human alk-SMase. Based o

Fifteen years after the heavy storm "Vivian", it is still not clear how succession in subalpine forests that were affected by the storm will continue and when regrowing forests will provide effective protection from natural hazards such as avalanches. We used a simulation model to evaluate forest succession, forest structure and the protective effect in subalpine blowdown areas after 50 simulation

Popular Abstract in Swedish Avhandlingens syfte är att analysera relationen och interaktionen mellan genus och nation i en svensk kontext under 1900-talets första hälft. När kvinnor mobiliseras nationellt inom olika typer av nationalism är det oftast moderskapet som åberopas. Detta är en av utgångspunkterna i avhandlingen. Föreställningar om ett nationellt moderskap återfinns också i flera olika sThe aim of this thesis is to analyse the relationship and interaction between gender and nation in a Swedish context, during the first half of the twentieth century. When women become mobilised on a nationwide basis within different types of nationalism, it is often motherhood that is invoked. This is just one point of departure in my dissertation. Perceptions of a national motherhood are also fou

Purpose: Prostaglandin E-2 and its EP1 receptor were suggested as endogenous modulators of bladder function in the normal physiological state and under pathophysiological conditions. We investigated if the new EP1 receptor antagonist PF-2907617-02 would influence the regulation of normal micturition in rats, and if it affects bladder function in animals with partial bladder outlet obstruction. Mat

Energy consumption is today an important design issue for all kinds of digital systems, and essential for the battery operated ones. An important fraction of this energy is dissipated on the processors running the application software. To reduce this energy consumption, one may, for instance, lower the processor clock frequency and supply voltage. This, however, might lead to a performance degrada

Background. Umbilical artery Doppler velocimetry is a routine method for fetal surveillance in high-risk pregnancy. Uterine artery Doppler seems to give comparable information, but it can be difficult to interpret as there are two arteries, which might show notching and/or increased pulsatility index (PI) as signs of increased vascular impedance. Combining the information on vascular resistance on

BACKGROUND: The atherothrombotic risk pattern of the nephrotic syndrome resembles that of hyperhomocysteinemia. However, the effect of nephrotic range proteinuria on homocysteine metabolism has never been studied. METHODS: The study included 11 male nephrotic patients with idiopathic membranous nephropathy who underwent a treatment trial with adrenocorticotrophic hormone and 11 male non-nephrotic,

Objectives: Tumor-associated-trypsin inhibitor (TATI) is frequently coexpressed with trypsinogen in tumors. Recently, we found expression of trypsinogens in prostate cancer. We have now studied whether TATI is also expressed in prostate cancer and if TATI expression is associated with Gleason grade, proliferation, and neuroendocrine differentiation. Methods: Expression of TATI and prostate-specifi

A novel design of a biochemical oxygen demand (BOD) biosensor has been developed for on-line monitoring of easily biodegradable organic compounds in aqueous samples. The biological recognition element of the sensor could be easily renewed by injecting new bacterial paste without disassembling the sensor system. The sensor measurements were carried out in the initial-rate mode using a flow injectio

The eating quality of M. longissimus dorsi (LD) from RN- homozygotes, RN- heterozygotes and RN- non-carriers was investigated in a Swedish Hampshire x Finnish Landrace pig population. The recently identified new allele (V1991, here denoted rn*) at the RN locus was also detected among the pigs selected and included in the sensory evaluation. The number of animals varied from 10 to 15 in the five ge

The process stability of water-in-oil-in-water (W/O/W) double emulsions stabilized with food-grade OSA modified quinoa starch granules was investigated. The effect of oils with differing melting points, as well as the effect of in situ partial gelatinization of the granules, on stability of emulsions was also investigated. The physical stability and release of a tracer (carmine) from the internal