SPIRIT-Children and Adolescents (SPIRIT-C) 2026 Extension Statement : Enhancing the Reporting and Usefulness of Pediatric Randomized Trial Protocols
IMPORTANCE: Key information is often omitted from pediatric randomized controlled trial (RCT) protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmental appropriateness of trial outcome measures and processes; or strategies to minimize participants' anxiety and pain. These deficiencies impair the planning and implementation of potent
