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Genes and proteins are known to have differences in their sensitivity to alterations. Despite numerous sequencing studies, proportions of harmful and harmless substitutions are not known for proteins and groups of proteins. To address this question, we predicted the outcome for all possible single amino acid substitutions (AASs) in nine representative protein groups by using the PON-P2 method. The

Pancreatic endocrine cell differentiation depends on transcription factors that also contribute in adult insulin and glucagon gene expression. Islet cell development was examined in mice lacking MafB, a transcription factor expressed in immature alpha (glucagon(+)) and beta (insulin(+)) cells and capable of activating insulin and glucagon expression in vitro. We observed that MafB(-/-) embryos had

The incidence of melanoma in Sweden is catching up on Australia and is now close to 40/100 000 inhabitants/ year, an increase of more than 5 %/year during the last 10 years. Swedes love the sun and travel a lot to sunny places like Spain and Thailand. There is a clear socioeconomic trend: the better economy and education, the more you travel and the more melanoma you get. Sunbed use is a clear ris

During the last two centuries, taxation has not only increased dramatically in level and volume; its structure has also changed: from a heavy reliance on customs revenue in the early nineteenth century to a stronger emphasis on income taxation in the twentieth. A common explanation for this development is the spread of democracy, which supposedly increases redistribution and the size of government

The theoretical understanding of inline rotor-stator mixer (RSM) efficiency, described in terms of the dissipation rate of turbulent kinetic energy as a function of mixer design and operation, is still poor. As opposed to the correlations for shaft power draw, where a substantial amount of experimental support for the suggested correlations exists, the previously suggested correlations for the dis

Background: An important aspect of research regarding the implementation of evidence-based practice is the sustainability and long-term stability of a programme. There is a need to measure these critical components for establishing successful programmes. Aim: The aim was to develop and pilot test the sustainable implementation scale (SIS) for measuring the critical components in the sustainable im

Underlining the too widespread underestimation of cultural differences by managers, international management literature problematizes culture as a critical factor for global competitiveness. Evidence from recent critical research (e.g. Westwood 2006) has shown that many of the main works within cross-cultural management (especially Hofstede 1980) and more broadly international management can be se

Fire models are used increasingly for fire safety assessment in nuclear power plants. Examples of these fire models are CFD models and zone models. When using these models it is important that they are sufficiently verified and validated. In Sweden the majority of fire safety consultants are using FDS, developed by NIST. The verification and validation of this package is intensively done for a num

Hematopoietic stem cells possess lifelong self-renewal activity and generate multipotent progenitors that differentiate into lineage-committed and subsequently mature cells. We present a comparative transcriptome analysis of ex vivo isolated mouse multipotent hematopoietic stem/progenitor cells (Lin(neg)SCA-1(+)c-KIT(+)) and myeloid committed precursors (Lin(neg)SCA-1(neg)c-KIT(+)). Our data displ

The lower matrix protein (pp65) is a major product of many laboratory strains of cytomegalovirus (CMV). It is thus an integral part of many CMV serological assays based on native antigen. Recombinant fragments of pp65 have previously been investigated for their usefulness in more-defined assays. The latter antigens have, however, failed to develop a positive response with serum samples derived fro

The Chinese government has been promoting the anaerobic treatment technology not only for pollution control but also for bioenergy recovery. Millions of decentralized anaerobic digesters have been built using animal manure and crop stalk as feedstock to improve the sanitary conditions and to produce biogas for heating and lighting for farmers and rural communities. Also, there are 22,570 medium to

Previous reports have connected non-symbiotic and truncated hemoglobins (Hbs) to metabolism of nitric oxide (NO), an important signalling molecule involved in wood formation. We have studied the capability of poplar (Populus tremula × tremuloides) Hbs PttHb1 and PttTrHb proteins alone or with a flavin-protein reductase to relieve NO cytotoxicity in living cells. Complementation tests in a Hb-defic

A fundamental problem in vision is how to identify the occluding contours of objects and surfaces, given the ambiguity inherent in low-level visual input. A computational model is proposed for how occluding contours could be identified by making use of simple heuristics that reduce the ambiguity of individual features. In the striate cortex, a large majority of cells are selective for both contras

OBJECTIVES: An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (IHD) mortality. METHODS: Multivariate 10-year survival analysis in a population