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BACKGROUND: Morphologic examination of bone marrow and peripheral blood samples continues to be the cornerstone in diagnostic hematology. In recent years, interest in automatic leukocyte classification using image analysis has increased rapidly. Such systems collect a series of images in which each cell must be segmented accurately to be classified correctly. Although segmentation algorithms have

Stigma has been identified as one of the most important obstacles for a successful integration of people with mental illness into the society. Research about stigma has shown negative attitudes among the public towards people with mental illness. Studies so far have, however, put little emphasis on how these negative attitudes are perceived by the mentally ill persons. The aim of the present study

The Kullaberg peninsula in NW Skåne renders km-long, continuous exposures of the Proterozoic crystalline basement. We report ion microprobe (SIMS) U–Pb zircon ages for six key lithologies at Kullaberg that constrain the geological history of SW Fennoscandia for a considerable time period. Igneous zircon in three varieties of gneiss granite yield ages of 1694±7 Ma, 1693±7 Ma and 1663±14 Ma, in the

For the analysis of small concentrations of organics in aqueous solutions, a novel add-on accessory for dual-beam / optical subtraction spectroscopy has been built for a commercial Fourier transform infrared spectrometer. A standard FT-IR instrument requires a sample measurement and a separate reference measurement, whereas the optical subtraction instrument directly measures the difference betwee

in this paper, we introduce two new methods for solving binary quadratic problems. While spectral relaxation methods have been the workhorse subroutine for a wide variety of computer vision problems-segmentation, clustering, subgraph matching to name a few-it has recently been challenged by semidefinite programming (SDP) relaxations. In fact, it can be shown that SDP relaxations produce better low

The distribution of substituents along the polymer backbone will have a strong influence on the properties of modified cellulose. Endoglucanases were used to degrade a series of hydroxypropyl cellulose (HPC) derivatives with a high degree of substitution. The HPCs were characterized with cloud-point analysis prior to degradation. The extent of enzymatic degradation was determined with size-exclusi

BACKGROUND: Electroconvulsive therapy (ECT) is a widely used and efficient treatment modality in psychiatry, although the basis for its therapeutic effect is still unknown. Past research has shown seizure activity to be a regulator of neurogenesis in the adult brain. This study examines the effect of a single and multiple electroconvulsive seizures on neurogenesis in the rat dentate gyrus. METHODS

The general anesthetics halothane and chloroform are capable of binding to synthetic water-soluble four--helix bundles, which model the putative in vivo receptors. In this study, we investigate the binding of these anesthetics to synthetic water-soluble three--helix bundles. A series of variants containing up to four X-to-Ala and up to four X-to-Met substitutions was made; and the effect of these

We test whether individual health status is related to area-level social capital measured by rates of voting participation in municipal political elections, controlling for personal characteristics, where health status is measured by mapping responses to interview survey questions into the generic health-related quality of life measure (HRQoL) the EQ-5D in order to derive the health state scores.

An assay has been established for quantitative evaluation of lentivirus coreceptor use with the help of GHOST(3) cells. GHOST(3) cells were derived from the human osteosarcoma cell line, HOS, and have been engineered to stably express CD4 and one or another of the chemokine receptors CCR3, CCR5, CXCR4, CXCR6/STRL33/Bonzo, or the orphan receptor GPR15/BOB. The indicator cell line carries the HIV-2

Osteonecrosis of the femoral head following femoral neck fractures is a common condition. Spontaneous osteonecrosis, is, however, a rare disorder, which is observed with increased frequency in alcohol abusers. In this retrospective study, we followed 512 consecutive male patients who had sustained femoral neck fractures between 1984 and 1992; 82 of these 512 patients (16%) had earlier been registe