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New synthetic hybrid materials and their increasing complexity have placed growing demands on crystal growth for single-crystal X-ray diffraction analysis. Unfortunately, not all chemical systems are conducive to the isolation of single crystals for traditional characterization. Here, small-molecule serial femtosecond crystallography (smSFX) at atomic resolution (0.833 Å) is employed to characteri
Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be class
Results of a measurement of dimuon photoproduction in nonultraperipheral Pb + Pb collisions at √sNN = 5.02 TeV are presented. Themeasurement uses ATLAS data from the 2015 and 2018 Pb + Pb data-taking periods at the LHC with an integrated luminosity of 1.94 nb.1. The γγ → μ+ μ- pairs are identified via selections on pair momentum asymmetry and acoplanarity. Differential cross sections for dimuon pr
This article analyses infant and child sex ratios in late Imperial Russia relying on district-level information obtained from the 1897 Russian census (489 districts). The article shows that child sex ratios were, on average, relatively low (around 98 boys per hundred girls) due to the biological female advantage: the extremely high infant and child mortality rates took a greater toll on boys and p
Background: Depression and anxiety often reduce people’s ability to cope with everyday occupations. There is a lack of knowledge about such problems in people of working age with depression and anxiety. Aim: To describe which problems people with depression or anxiety disorders experience when performing everyday occupations and which occupations are affected. Materials and methods: Data based on
Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow-up since 1995, we performed genome-wide association analyses of longitudinal patterns of medication use in hyperlipidemia, hypertension and type 2 diabetes in up to 193,933 individuals (55% women) in the FinnGen study. In meta-anal
Plant hemoglobins, often referred to as phytoglobins, play important roles in abiotic stress tolerance. Several essential small physiological metabolites can be bound to these heme proteins. In addition, phytoglobins can catalyze a range of different oxidative reactions in vivo. These proteins are often oligomeric, but the degree and relevance of subunit interactions are largely unknown. In this s
Purpose: Ovarian cancer ranks as a gynecological malignancy with poor prognosis, specifically if detected late. Primary treatment includes cytoreductive surgery and adjuvant chemotherapy with curative intent. Local anesthetics (LA) administered in the perioperative period may potentially impact patient outcome by several mechanisms. The beneficial impact of LA has been attributed, among other fact
To evaluate the behaviour of a single timber-concrete composite (TCC) T-beam, a simplified 2D finite element (FE) model in Abaqus is developed and validated using experimental tests and the Gamma method given in Annex B of EN 1995–1-1. The shear connection used in the beam consist of perfobond connectors, which are adhesively bonded to the timber beam. In the developed model, beam and shell finite
This meta-review evaluated the possibility of more specified recommendations in antibiotic treatment through a narrowed focus on facial trauma. The aim was to analyze the effect of different regimens of antibiotic in treatment of skeletal trauma to the face. The knowledge mapping was based on existing systematic reviews (SRs) on trials specified in a PICO: Participants (P): Adults and children, di
Recent technological developments in warehousing have introduced new risks. This paper presents an integrative review that combines insights from highly automated warehouse systems (HAWS) and risk management, providing a comprehensive understanding of technology-related warehouse disruptions and vulnerabilities. We identify five major disruptions that can affect HAWS: cyberattacks, technology sabo
Estuaries are complex environments rich in biodiversity, making it challenging to understand the distribution and occurrence of microplastics due to the multiple variables that can influence the movement of these particles. Based on this, this study evaluated the influence of different environmental aspects on the distribution and transport of microplastics in the surface waters of the Tramandaí R
Chaperone proteins are essential for maintaining proteostasis. Their main role is to assist with the folding of other proteins and to prevent the aggregation of misfolded proteins. The molecular chaperone DNAJB6b efficiently suppresses amyloid formation of several peptides. This activity may rely on the same physicochemical properties as those driving chaperone self-assembly into large micellar-li
