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The mechanisms that specify photoreceptor cell-fate determination, especially as regards to short-wave-sensitive (S) versus medium-wave-sensitive (M) cone identity, and maintain their nature and function, are not fully understood. Here we report the importance of general transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) in maintaining M cone cell identity and function as well
BACKGROUND: The study investigated whether 3D vision and haptic feedback in combination in a virtual reality environment leads to more efficient learning of laparoscopic skills in novices.MATERIAL AND METHODS: Twenty novices were allocated to two groups. All completed a training course in the LapSim(®) virtual reality trainer consisting of four tasks: 'instrument navigation', 'grasping', 'fine dis
The TIMESAT software package has been developed to enable monitoring of dynamic land surface processes using remotely sensed data. The monitoring capability is based on processing of time-series for each image pixel using either of three smoothing methods included in TIMESAT: asymmetric Gaussian fits, doublelogistic fits, and Savitzky-Golay filtering. The methods have different properties and are
Bacterial taxonomic community analyses using PCR-amplification of the 16S rRNA gene and high-throughput sequencing has become a cornerstone in microbiology research. To reliably detect the members, or operational taxonomic units (OTUs), that make up bacterial communities, taxonomic surveys rely on the use of the most informative PCR primers to amplify the broad range of phylotypes present in up-to
Purpose: This paper aims to discuss the current debates in facility management to understand where the research community is working and where the facility management sector and discipline might be heading. Design/methodology/approach: A review of research outputs has been undertaken to identify research themes. The discussion is based on developments that are already shaping how one should view f
Inflammation leads to activation of immune cells, resulting in production of hypobromous acid. Few investigations have been performed on protein bromination on a proteomic scale, even though bromination is a relatively abundant protein modification in endogenously brominated proteomes. Such studies have been hampered by the lack of an optimized database search strategy. In order to address this is
The rhinarium, a specialized nose-tip characterized by an area of naked and wet skin around the nostrils, is a typical mammalian structure. The type and amount of innervation suggests a sensory role and morphological diversity implies so far unidentified species-specific functional specializations. Rhinaria also vary in temperature and this may be related to the functions of these sensory organs.
Molecular dynamics (MD) simulations contain considerable information with regard to the motions and fluctuations of a protein, the magnitude of which can be used to estimate conformational entropy. Here we survey conformational entropy across protein fold space using the Dynameomics database, which represents the largest existing data set of protein MD simulations for representatives of essentiall
The measurement of prompt D-meson production as a function of multiplicity in p-Pb collisions at sNN=5.02 TeV with the ALICE detector at the LHC is reported. D0, D+ and D∗+ mesons are reconstructed via their hadronic decay channels in the centre-of-mass rapidity range −0.96 < ycms< 0.04 and transverse momentum interval 1
Measurements of the per-event charged-particle yield as a function of the charged-particle transverse momentum and rapidity are performed using p+Pb collision data collected by the ATLAS experiment at the LHC at a centre-of-mass energy of sNN=5.02TeV. Charged particles are reconstructed over pseudorapidity |η|<2.3 and transverse momentum between 0.1 GeV and 22 GeV in a dataset corresponding to an
The pocket cavity is generated at the transition part between the low pressure turbine (LPT) and outlet guide vane (OGV) in a gas turbine engine. Because the important connection with OGV, the heat transfer and fluid flow need to be investigated and analyzed. In the present work, a simplified triangular pocket cavity is built and heat transfer and fluid flow are investigated experimentally and num
The purpose of this paper is to empirically explore antecedents associated with information sharing across multiple supply chain tiers. We conduct a Delphi study with 29 supply chain experts to collect qualitative and quantitative data, and identify a total of 22 factors that are grouped into six categories: information utilization, technology utilization, power structures, culture, business proce
In this study, multi-objective optimization of the performance of a solar receiver with dimple and delta-winglet vortex generators (DWVGs) is carried out. The thermal performance and outlet dimensionless turbulent kinetic energy (TKE) are chosen as the optimization objectives. The dimple depth, dimple arrangement, the length, height, angle and spacing of the DWVGs are selected as the optimization
Drawing on data derived from a nationwide postal survey (n = 1264) with a simple random sample of Swedes between ages 65 and 85 (response rate: 63%), the article analyses the general patterns of: (a) degrees of information and communication (ICT) access and (b) ICT-literacy among Swedish senior citizens. The overall patterns of access and literacy are analysed in light of senior citizens’ assets –
